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Conference Paper: Aspirin resistance and silent brain infarcts in asymptomatic aspirin users

TitleAspirin resistance and silent brain infarcts in asymptomatic aspirin users
Authors
Issue Date2013
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/CED
Citation
The Annual Conference of the Asia Pacific Stroke Organization (APSO), Hong Kong, China, 30 August-1 September 2013. In Cerebrovascular Diseases, 2013, v. 36 n. Supp. 1, p. 94, abstract no. EP-99 How to Cite?
AbstractBackground: It has been reported that aspirin resistance was correlated with severity and mortality in patients with symptomatic ischemic stroke. However, the relationship between aspirin resistance and silent stroke is unclear. Methods: From 2006 to 2009, we recruited 84 stroke-free aspirin users, including those with ischemic heart disease or atrial fibrillation. Silent brain infarcts (SBI), microbleeds (MB) and white matter hyperintensities (WMH) were determined by brain MRI. Platelet reactivity was reported as aspirin reaction unit (ARU). Aspirin resistance was defined as ARU≥550. Results: 9 (12.0%) patients had SBIs and 10 (13.3%) had MBs. Aspirin resistance was detected in 5 (6.0%) patients. Aspirin resistance, atrial fibrillation, presence of MBs and severe WMH were associated with the presence SBIs in chi-square tests (P < 0.05). ARU value was higher in patients with SBIs than those without (513.2 ± 74.0 vs. 448.4 ± 47.7, P < 0.05), which was the only significant factor after adjustment (OR 1.016, 95% CI 1.000– 1.031; P < 0.05). Patients with lower ARU value or longer duration of aspirin usage did not present with more MBs (P > 0.05). Conclusion: Aspirin resistance may be an indicator of silence brain infarcts in asymptomatic aspirin users.
Persistent Identifierhttp://hdl.handle.net/10722/204272
ISSN
2015 Impact Factor: 3.359
2015 SCImago Journal Rankings: 1.744

 

DC FieldValueLanguage
dc.contributor.authorXie, Ben_US
dc.contributor.authorAu Yeung, KMen_US
dc.contributor.authorTse, HFen_US
dc.contributor.authorCheung, RTFen_US
dc.date.accessioned2014-09-19T21:43:13Z-
dc.date.available2014-09-19T21:43:13Z-
dc.date.issued2013en_US
dc.identifier.citationThe Annual Conference of the Asia Pacific Stroke Organization (APSO), Hong Kong, China, 30 August-1 September 2013. In Cerebrovascular Diseases, 2013, v. 36 n. Supp. 1, p. 94, abstract no. EP-99en_US
dc.identifier.issn1015-9770-
dc.identifier.urihttp://hdl.handle.net/10722/204272-
dc.description.abstractBackground: It has been reported that aspirin resistance was correlated with severity and mortality in patients with symptomatic ischemic stroke. However, the relationship between aspirin resistance and silent stroke is unclear. Methods: From 2006 to 2009, we recruited 84 stroke-free aspirin users, including those with ischemic heart disease or atrial fibrillation. Silent brain infarcts (SBI), microbleeds (MB) and white matter hyperintensities (WMH) were determined by brain MRI. Platelet reactivity was reported as aspirin reaction unit (ARU). Aspirin resistance was defined as ARU≥550. Results: 9 (12.0%) patients had SBIs and 10 (13.3%) had MBs. Aspirin resistance was detected in 5 (6.0%) patients. Aspirin resistance, atrial fibrillation, presence of MBs and severe WMH were associated with the presence SBIs in chi-square tests (P < 0.05). ARU value was higher in patients with SBIs than those without (513.2 ± 74.0 vs. 448.4 ± 47.7, P < 0.05), which was the only significant factor after adjustment (OR 1.016, 95% CI 1.000– 1.031; P < 0.05). Patients with lower ARU value or longer duration of aspirin usage did not present with more MBs (P > 0.05). Conclusion: Aspirin resistance may be an indicator of silence brain infarcts in asymptomatic aspirin users.-
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/CED-
dc.relation.ispartofCerebrovascular Diseasesen_US
dc.rightsCerebrovascular Diseases. Copyright © S Karger AG.-
dc.titleAspirin resistance and silent brain infarcts in asymptomatic aspirin usersen_US
dc.typeConference_Paperen_US
dc.identifier.emailTse, HF: hftse@hkucc.hku.hken_US
dc.identifier.emailCheung, RTF: rtcheung@hku.hken_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.identifier.authorityCheung, RTF=rp00434en_US
dc.identifier.doi10.1159/000353795-
dc.identifier.hkuros236294en_US
dc.identifier.volume36en_US
dc.identifier.issueSupp. 1en_US
dc.identifier.spage94, abstract no. EP-99en_US
dc.identifier.epage94, abstract no. EP-99en_US
dc.publisher.placeSwitzerland-

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