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Conference Paper: Visit-to-visit systolic blood pressure variability predicts all-cause and cardiovascular mortality after lacunar infarct

TitleVisit-to-visit systolic blood pressure variability predicts all-cause and cardiovascular mortality after lacunar infarct
Authors
Issue Date2014
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
Citation
The 19th Medical Research Conference (MRC 2014), Hong Kong, China, 18 January 2014. In Hong Kong Medical Journal, 2014, v. 20 suppl. 1. p. 29, abstract no. 41 How to Cite?
AbstractBackground: Both blood pressure (BP) and its variability (BPV) are established risk factors for development of atherosclerotic disease and are associated with an increased risk for cardiovascular and all-cause mortality. The prognostic implications of out-patient clinic visit-to-visit BPV among patients with lacunar infarction are nevertheless unknown. Methods: We prospectively followed up the clinical outcome of 281 patients with lacunar infarction. The mean BP and BPV, as determined by the standard deviation of the systolic and diastolic BP, were recorded during a mean of 13 ± 6 out-patient clinic visits. Results: The mean age of the population was 70 ± 10 years. After a mean of 78 ± 18 month’s follow-up, 65 (23%) patients died, 31% (20/65) were due to cardiovascular causes. 14% and 7% developed recurrent stroke and acute coronary syndrome, respectively. After adjusting for age, sex, mean systolic and diastolic BP, cardiovascular risk factors and co-morbidities, patients with a systolic BPV of the third tertile had significantly higher risk of all-cause (hazard ratio [HR] = 1.97; 95% confidence interval [CI], 1.02-3.80; P = 0.04) and cardiovascular mortality (HR = 7.64; 95% CI, 1.65-35.41; P < 0.01) compared to those with systolic BPV of the first tertile. Nevertheless, systolic BPV did not predict recurrent stroke or acute coronary syndrome. Diastolic BPV did not predict various adverse clinical outcomes. Conclusions: Visit-to-visit systolic BPV predicts long-term all-cause and cardiovascular mortality after lacunar infarct, independent of conventional risk factors including average BP control.
Persistent Identifierhttp://hdl.handle.net/10722/204270
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorLau, GKKen_US
dc.contributor.authorWong, YKen_US
dc.contributor.authorChang, SKRen_US
dc.contributor.authorTeo, KCen_US
dc.contributor.authorHon, FKSen_US
dc.contributor.authorChan, KHen_US
dc.contributor.authorWat, KLen_US
dc.contributor.authorCheung, RTFen_US
dc.contributor.authorLi, LSWen_US
dc.contributor.authorSiu, DCWen_US
dc.contributor.authorHo, SLen_US
dc.contributor.authorTse, HFen_US
dc.date.accessioned2014-09-19T21:43:13Z-
dc.date.available2014-09-19T21:43:13Z-
dc.date.issued2014en_US
dc.identifier.citationThe 19th Medical Research Conference (MRC 2014), Hong Kong, China, 18 January 2014. In Hong Kong Medical Journal, 2014, v. 20 suppl. 1. p. 29, abstract no. 41en_US
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/204270-
dc.description.abstractBackground: Both blood pressure (BP) and its variability (BPV) are established risk factors for development of atherosclerotic disease and are associated with an increased risk for cardiovascular and all-cause mortality. The prognostic implications of out-patient clinic visit-to-visit BPV among patients with lacunar infarction are nevertheless unknown. Methods: We prospectively followed up the clinical outcome of 281 patients with lacunar infarction. The mean BP and BPV, as determined by the standard deviation of the systolic and diastolic BP, were recorded during a mean of 13 ± 6 out-patient clinic visits. Results: The mean age of the population was 70 ± 10 years. After a mean of 78 ± 18 month’s follow-up, 65 (23%) patients died, 31% (20/65) were due to cardiovascular causes. 14% and 7% developed recurrent stroke and acute coronary syndrome, respectively. After adjusting for age, sex, mean systolic and diastolic BP, cardiovascular risk factors and co-morbidities, patients with a systolic BPV of the third tertile had significantly higher risk of all-cause (hazard ratio [HR] = 1.97; 95% confidence interval [CI], 1.02-3.80; P = 0.04) and cardiovascular mortality (HR = 7.64; 95% CI, 1.65-35.41; P < 0.01) compared to those with systolic BPV of the first tertile. Nevertheless, systolic BPV did not predict recurrent stroke or acute coronary syndrome. Diastolic BPV did not predict various adverse clinical outcomes. Conclusions: Visit-to-visit systolic BPV predicts long-term all-cause and cardiovascular mortality after lacunar infarct, independent of conventional risk factors including average BP control.-
dc.languageengen_US
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk-
dc.relation.ispartofHong Kong Medical Journalen_US
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleVisit-to-visit systolic blood pressure variability predicts all-cause and cardiovascular mortality after lacunar infarcten_US
dc.typeConference_Paperen_US
dc.identifier.emailLau, GKK: gkklau@hku.hken_US
dc.identifier.emailChang, SKR: skrchang@hku.hken_US
dc.identifier.emailChan, KH: koonho@hku.hken_US
dc.identifier.emailCheung, RTF: rtcheung@hku.hken_US
dc.identifier.emailLi, LSW: lswli@hkucc.hku.hken_US
dc.identifier.emailSiu, DCW: cwdsiu@hkucc.hku.hken_US
dc.identifier.emailHo, SL: slho@hku.hken_US
dc.identifier.emailTse, HF: hftse@hkucc.hku.hken_US
dc.identifier.authorityLau, GKK=rp01499en_US
dc.identifier.authorityChan, KH=rp00537en_US
dc.identifier.authorityCheung, RTF=rp00434en_US
dc.identifier.authoritySiu, DCW=rp00534en_US
dc.identifier.authorityHo, SL=rp00240en_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros236288en_US
dc.identifier.volume20en_US
dc.identifier.issueSuppl. 1en_US
dc.identifier.spage29, abstract no. 41en_US
dc.identifier.epage29, abstract no. 41en_US
dc.publisher.placeHong Kong-

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