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Conference Paper: Separation and quantitative assessment of mobile lipid and lactate level by diffusion weighted magnetic resonance spectroscopy (DW-MRS)

TitleSeparation and quantitative assessment of mobile lipid and lactate level by diffusion weighted magnetic resonance spectroscopy (DW-MRS)
Authors
Issue Date2014
PublisherISMRM-ESMRMB 2014.
Citation
The 2014 ISMRM-ESMRMB Joint Annual Meeting, Milano, Italy, 10-16 May 2014. How to Cite?
AbstractThis study explored the capability of Diffusion Weighted Magnetic Resonance Spectroscopy (DW-MRS) for the separation and quantification of the overlapped mobile lipid and lactate signal at 1.3ppm. Both the content and ADC value can be computed from fitting the diffusion weighted signal to a bi-exponential decay model. In this rat model of intracerebral C6 glioma, the spectra from the tumor region was dominated by the mobile lipid signal and the lipid signal intensity is approximately ten times higher than the lactate signal. Our result also shows the lactate ADC in C6 glioma is 2.9(±0.9)×10–4 mm2/s and the lipid ADC is 3.3(±1.3)×10–4 mm2/s. Demonstrated by this study, the DW-MRS provides a feasible way to solve the overlapping problem of the lactate and mobile lipid peak at 1.3ppm, giving an alternative method for the quantification of lipid and lactate content in the clinical study.
DescriptionElectronic Poster Session - Cancer: Cancer Preclinical Studies: Cells & Animals: no. 4041
Persistent Identifierhttp://hdl.handle.net/10722/204155

 

DC FieldValueLanguage
dc.contributor.authorWang, AMen_US
dc.contributor.authorKiang, KMYen_US
dc.contributor.authorLeung, GKKen_US
dc.contributor.authorTsang, AHWen_US
dc.contributor.authorXie, VBen_US
dc.contributor.authorGuo, Hen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2014-09-19T20:07:20Z-
dc.date.available2014-09-19T20:07:20Z-
dc.date.issued2014en_US
dc.identifier.citationThe 2014 ISMRM-ESMRMB Joint Annual Meeting, Milano, Italy, 10-16 May 2014.en_US
dc.identifier.urihttp://hdl.handle.net/10722/204155-
dc.descriptionElectronic Poster Session - Cancer: Cancer Preclinical Studies: Cells & Animals: no. 4041-
dc.description.abstractThis study explored the capability of Diffusion Weighted Magnetic Resonance Spectroscopy (DW-MRS) for the separation and quantification of the overlapped mobile lipid and lactate signal at 1.3ppm. Both the content and ADC value can be computed from fitting the diffusion weighted signal to a bi-exponential decay model. In this rat model of intracerebral C6 glioma, the spectra from the tumor region was dominated by the mobile lipid signal and the lipid signal intensity is approximately ten times higher than the lactate signal. Our result also shows the lactate ADC in C6 glioma is 2.9(±0.9)×10–4 mm2/s and the lipid ADC is 3.3(±1.3)×10–4 mm2/s. Demonstrated by this study, the DW-MRS provides a feasible way to solve the overlapping problem of the lactate and mobile lipid peak at 1.3ppm, giving an alternative method for the quantification of lipid and lactate content in the clinical study.-
dc.languageengen_US
dc.publisherISMRM-ESMRMB 2014.-
dc.relation.ispartofISMRM-ESMRMB 2014 Joint Annual Meetingen_US
dc.titleSeparation and quantitative assessment of mobile lipid and lactate level by diffusion weighted magnetic resonance spectroscopy (DW-MRS)en_US
dc.typeConference_Paperen_US
dc.identifier.emailKiang, KMY: mykiang@hku.hken_US
dc.identifier.emailLeung, GKK: gilberto@hku.hk-
dc.identifier.emailTsang, AHW: ahwtsang@hku.hk-
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hk-
dc.identifier.authorityLeung, GKK=rp00522en_US
dc.identifier.authorityWu, EX=rp00193-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros227091en_US
dc.identifier.hkuros240630-
dc.identifier.spage8008-
dc.identifier.epage8008-

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