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Conference Paper: Diffusion magnetic resonance monitors intramyocellular lipid droplet size in vivo

TitleDiffusion magnetic resonance monitors intramyocellular lipid droplet size in vivo
Authors
Issue Date2014
PublisherISMRM-ESMRMB 2014.
Citation
The 2014 joint ISMRM-ESMRMB Annual Meeting, Milano, Italy, 10-16 May 2014. How to Cite?
AbstractIntramyocellular lipid (IMCL) droplets are dynamic organelles whose morphology reflects their vital roles in lipid synthesis, utilization and storage in muscle energy metabolism. To develop non-invasive means to measure droplet microstructure in vivo, we investigated the molecular diffusion behavior of IMCL with diffusion MR spectroscopy. Our results demonstrate the feasibility of MR diffusion characterization of IMCL droplet microstructure and provide evidence of the sensitivity of this method to metabolic alterations. The use of diffusion MR methodology in vivo promises to provide new biophysical insights in the investigation of droplet dynamics and lipid metabolism in both animal models and human subjects. The diffusion MR results may help contribute to an improved understanding and diagnosis of obesity, diabetes and other metabolic disorders.
DescriptionScientific Session - Young Investigator Award Presentations: no. 0020
Persistent Identifierhttp://hdl.handle.net/10722/204132

 

DC FieldValueLanguage
dc.contributor.authorCao, Pen_US
dc.contributor.authorFan, Sen_US
dc.contributor.authorWang, AMen_US
dc.contributor.authorXie, VBen_US
dc.contributor.authorQiao, Zen_US
dc.contributor.authorBrittenham, GMen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2014-09-19T20:06:31Z-
dc.date.available2014-09-19T20:06:31Z-
dc.date.issued2014en_US
dc.identifier.citationThe 2014 joint ISMRM-ESMRMB Annual Meeting, Milano, Italy, 10-16 May 2014.en_US
dc.identifier.urihttp://hdl.handle.net/10722/204132-
dc.descriptionScientific Session - Young Investigator Award Presentations: no. 0020-
dc.description.abstractIntramyocellular lipid (IMCL) droplets are dynamic organelles whose morphology reflects their vital roles in lipid synthesis, utilization and storage in muscle energy metabolism. To develop non-invasive means to measure droplet microstructure in vivo, we investigated the molecular diffusion behavior of IMCL with diffusion MR spectroscopy. Our results demonstrate the feasibility of MR diffusion characterization of IMCL droplet microstructure and provide evidence of the sensitivity of this method to metabolic alterations. The use of diffusion MR methodology in vivo promises to provide new biophysical insights in the investigation of droplet dynamics and lipid metabolism in both animal models and human subjects. The diffusion MR results may help contribute to an improved understanding and diagnosis of obesity, diabetes and other metabolic disorders.-
dc.languageengen_US
dc.publisherISMRM-ESMRMB 2014.-
dc.relation.ispartofISMRM-ESMRMB Annual Meeting 2014en_US
dc.titleDiffusion magnetic resonance monitors intramyocellular lipid droplet size in vivoen_US
dc.typeConference_Paperen_US
dc.identifier.emailCao, P: caopeng1@hku.hken_US
dc.identifier.emailFan, S: fanshj08@hkucc.hku.hken_US
dc.identifier.emailQiao, Z: zwqiao@hku.hk-
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hk-
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros240595en_US
dc.publisher.placeItalyen_US

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