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Conference Paper: Asymmetric-detection time-stretch optical microscopy (ATOM) for high-contrast and high-speed microfluidic cellular imaging

TitleAsymmetric-detection time-stretch optical microscopy (ATOM) for high-contrast and high-speed microfluidic cellular imaging
Authors
Issue Date2014
PublisherS P I E - International Society for Optical Engineering. The Journal's web site is located at http://spie.org/x1848.xml?WT.svl=mddp2
Citation
Conference 8947 - Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII, San Francisco, California, USA, 3-6 February 2014. In Proceedings of SPIE - International Society for Optical Engineering, 2014, v. 8947, p. article no. 89471D How to Cite?
AbstractHigh-throughput cellular imaging is acclaimed as captivating yet challenging in biomedical diagnostics. We have demonstrated a new imaging modality, asymmetric-detection time-stretch optical microscopy (ATOM), by incorporating a simple detection scheme which is a further advancement in time-stretch microscopy - a viable solution to achieve high-speed and high-throughput cellular imaging. Through the asymmetric-detection scheme in ATOM, the time-stretch image contrast is enhanced through accessing to the phase-gradient information. With the operation in the 1 μm wavelength range, we demonstrate high-resolution and high-contrast cellular imaging in ultrafast microfluidic flow (up to 10 m/s) by ATOM - achieving an imaging throughput equivalent to 100,000 cells/sec. © 2014 SPIE.
Persistent Identifierhttp://hdl.handle.net/10722/204010
ISBN
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, TWen_US
dc.contributor.authorLau, KSen_US
dc.contributor.authorTang, YHen_US
dc.contributor.authorHo, KYen_US
dc.contributor.authorWong, KKYen_US
dc.contributor.authorShum, HCen_US
dc.contributor.authorTsia, KKMen_US
dc.date.accessioned2014-09-19T20:01:37Z-
dc.date.available2014-09-19T20:01:37Z-
dc.date.issued2014en_US
dc.identifier.citationConference 8947 - Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII, San Francisco, California, USA, 3-6 February 2014. In Proceedings of SPIE - International Society for Optical Engineering, 2014, v. 8947, p. article no. 89471Den_US
dc.identifier.isbn9780819498601-
dc.identifier.issn0277-786X-
dc.identifier.urihttp://hdl.handle.net/10722/204010-
dc.description.abstractHigh-throughput cellular imaging is acclaimed as captivating yet challenging in biomedical diagnostics. We have demonstrated a new imaging modality, asymmetric-detection time-stretch optical microscopy (ATOM), by incorporating a simple detection scheme which is a further advancement in time-stretch microscopy - a viable solution to achieve high-speed and high-throughput cellular imaging. Through the asymmetric-detection scheme in ATOM, the time-stretch image contrast is enhanced through accessing to the phase-gradient information. With the operation in the 1 μm wavelength range, we demonstrate high-resolution and high-contrast cellular imaging in ultrafast microfluidic flow (up to 10 m/s) by ATOM - achieving an imaging throughput equivalent to 100,000 cells/sec. © 2014 SPIE.-
dc.languageengen_US
dc.publisherS P I E - International Society for Optical Engineering. The Journal's web site is located at http://spie.org/x1848.xml?WT.svl=mddp2-
dc.relation.ispartofProceedings of SPIE - International Society for Optical Engineeringen_US
dc.rightsProceedings of SPIE - International Society for Optical Engineering. Copyright © S P I E - International Society for Optical Engineering.-
dc.rightsCopyright notice format: Copyright 2014 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleAsymmetric-detection time-stretch optical microscopy (ATOM) for high-contrast and high-speed microfluidic cellular imagingen_US
dc.typeConference_Paperen_US
dc.identifier.emailWong, KKY: kywong04@hkucc.hku.hken_US
dc.identifier.emailShum, HC: ashum@hku.hken_US
dc.identifier.emailTsia, KKM: tsia@hku.hken_US
dc.identifier.authorityWong, KKY=rp00189en_US
dc.identifier.authorityShum, HC=rp01439en_US
dc.identifier.authorityTsia, KKM=rp01389en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1117/12.2038952-
dc.identifier.scopuseid_2-s2.0-84901771165-
dc.identifier.hkuros236209en_US
dc.identifier.volume8947-
dc.identifier.isiWOS:000336037200029-
dc.publisher.placeUnited States-

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