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Conference Paper: Visit-to-visit blood pressure variability is associated with periventricular white matter hyperintensity in healthy hypertensive elderly Chinese

TitleVisit-to-visit blood pressure variability is associated with periventricular white matter hyperintensity in healthy hypertensive elderly Chinese
Authors
Issue Date2014
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
Citation
The 19th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, China, 18 January 2014. In Hong Kong Medical Journal, 2014, v. 20 n. Suppl. 1. p. 46, abstract no. 76 How to Cite?
AbstractBackground: Visit-to-visit blood pressure variability (BPV) has been reported to be associated with the severity and prognosis of symptomatic stroke, but its correlation with silent stroke is unclear. We aimed to evaluate the relationship between BPV and silent cerebral vascular lesions (SCVL). Methods: A total of 239 healthy hypertensive Chinese aged more than 65 years were recruited. SCVLs including silent brain infarcts (BIs), microbleeds (MBs), and white matter hyperintensity (WMH) were determined by magnetic resonance images on a 3T scanner. The severity of WMH was rated using the Fazekas white matter scale. Previous 3-year blood pressure measurements were collected from the electronic medical record. BPV parameters—including standard deviation, coefficient of variation, successive variation, and variation independent of mean blood pressure—were calculated. Statistical analyses were performed to evaluate the significance of relationships. Result: Of the patients, 26 (10.9%) and 12 (5.0%) had severe periventricular WMH and deep WMH (Fazekas score = 3), respectively. Both systolic and diastolic BPV parameters were correlated with the severity of periventricular WMH (P < 0.05) but not the severity of deep WMH, presence of BIs or MBs. The relationship between BPV parameters and periventricular WMH still existed after adjustment for age and other factors. Conclusion: BPV was an independent predictor of severe periventricular WMH in healthy hypertensive elderly.
DescriptionOral Presentation
Persistent Identifierhttp://hdl.handle.net/10722/203985
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorXoe, Ben_US
dc.contributor.authorZhang, Men_US
dc.contributor.authorMak, HKFen_US
dc.contributor.authorCheung, RTFen_US
dc.date.accessioned2014-09-19T19:48:25Z-
dc.date.available2014-09-19T19:48:25Z-
dc.date.issued2014en_US
dc.identifier.citationThe 19th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, China, 18 January 2014. In Hong Kong Medical Journal, 2014, v. 20 n. Suppl. 1. p. 46, abstract no. 76en_US
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/203985-
dc.descriptionOral Presentation-
dc.description.abstractBackground: Visit-to-visit blood pressure variability (BPV) has been reported to be associated with the severity and prognosis of symptomatic stroke, but its correlation with silent stroke is unclear. We aimed to evaluate the relationship between BPV and silent cerebral vascular lesions (SCVL). Methods: A total of 239 healthy hypertensive Chinese aged more than 65 years were recruited. SCVLs including silent brain infarcts (BIs), microbleeds (MBs), and white matter hyperintensity (WMH) were determined by magnetic resonance images on a 3T scanner. The severity of WMH was rated using the Fazekas white matter scale. Previous 3-year blood pressure measurements were collected from the electronic medical record. BPV parameters—including standard deviation, coefficient of variation, successive variation, and variation independent of mean blood pressure—were calculated. Statistical analyses were performed to evaluate the significance of relationships. Result: Of the patients, 26 (10.9%) and 12 (5.0%) had severe periventricular WMH and deep WMH (Fazekas score = 3), respectively. Both systolic and diastolic BPV parameters were correlated with the severity of periventricular WMH (P < 0.05) but not the severity of deep WMH, presence of BIs or MBs. The relationship between BPV parameters and periventricular WMH still existed after adjustment for age and other factors. Conclusion: BPV was an independent predictor of severe periventricular WMH in healthy hypertensive elderly.-
dc.languageengen_US
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk-
dc.relation.ispartofHong Kong Medical Journalen_US
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleVisit-to-visit blood pressure variability is associated with periventricular white matter hyperintensity in healthy hypertensive elderly Chineseen_US
dc.typeConference_Paperen_US
dc.identifier.emailMak, HKF: makkf@hkucc.hku.hken_US
dc.identifier.emailCheung, RTF: rtcheung@hku.hken_US
dc.identifier.authorityMak, HKF=rp00533en_US
dc.identifier.authorityCheung, RTF=rp00434en_US
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros236232en_US
dc.identifier.volume20en_US
dc.identifier.issueSuppl. 1en_US
dc.identifier.spage46, abstract no. 76en_US
dc.identifier.epage46, abstract no. 76en_US
dc.publisher.placeHong Kong-

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