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Conference Paper: Gli-mediated regulation of Sox9 in limb development

TitleGli-mediated regulation of Sox9 in limb development
Authors
Issue Date2013
Citation
The 9th Pan Pacific Connective Tissue Societies Symposium (PPCTSS 2013), Hong Kong, China, 24-27 November 2013. In Program Book, 2013, abstract no. 0037 How to Cite?
AbstractThe transcription factor SOX9 is essential for skeletogenesis and heterozygous mutations in the gene cause Campomelic Dysplasia (CD). Recently, chromosomal aberrations at >1Mb from SOX9 coding region have been detected in some CD patients, suggesting the requirement of long-range regulatory elements in controlling the precise expression of SOX9 for proper skeletal development. However, the exact identities of these elements or the transcription factors that direct appropriate expression of SOX9 are unknown. Here, we identified nine conserved putative enhancers of SOX9. Molecular and genetic analyses suggest Shh-Gli pathways as potential upstream regulatory networks that govern the spatiotemporal and dosage of limb Sox9 expression via predicted enhancers. Our study will provide novel insights on molecular mechanism governing the complex patterning of Sox9 in the developing limb, and the disease mechanisms of CD.
DescriptionConference Theme: The Extracellular Matrix Niche
Oral Presentation
Session 4: Matrix integrity and mechanobiology
The Program can be viewed at: http://ppctss2013.org/Online%20Program%20Book.pdf
Persistent Identifierhttp://hdl.handle.net/10722/203901

 

DC FieldValueLanguage
dc.contributor.authorYip, KHRen_US
dc.contributor.authorWu, MHen_US
dc.contributor.authorHui, CCen_US
dc.contributor.authorChan, Den_US
dc.contributor.authorCheah, KSEen_US
dc.contributor.authorCheung, MCH-
dc.date.accessioned2014-09-19T16:43:18Z-
dc.date.available2014-09-19T16:43:18Z-
dc.date.issued2013en_US
dc.identifier.citationThe 9th Pan Pacific Connective Tissue Societies Symposium (PPCTSS 2013), Hong Kong, China, 24-27 November 2013. In Program Book, 2013, abstract no. 0037en_US
dc.identifier.urihttp://hdl.handle.net/10722/203901-
dc.descriptionConference Theme: The Extracellular Matrix Niche-
dc.descriptionOral Presentation-
dc.descriptionSession 4: Matrix integrity and mechanobiology-
dc.descriptionThe Program can be viewed at: http://ppctss2013.org/Online%20Program%20Book.pdf-
dc.description.abstractThe transcription factor SOX9 is essential for skeletogenesis and heterozygous mutations in the gene cause Campomelic Dysplasia (CD). Recently, chromosomal aberrations at >1Mb from SOX9 coding region have been detected in some CD patients, suggesting the requirement of long-range regulatory elements in controlling the precise expression of SOX9 for proper skeletal development. However, the exact identities of these elements or the transcription factors that direct appropriate expression of SOX9 are unknown. Here, we identified nine conserved putative enhancers of SOX9. Molecular and genetic analyses suggest Shh-Gli pathways as potential upstream regulatory networks that govern the spatiotemporal and dosage of limb Sox9 expression via predicted enhancers. Our study will provide novel insights on molecular mechanism governing the complex patterning of Sox9 in the developing limb, and the disease mechanisms of CD.-
dc.languageengen_US
dc.relation.ispartofPan Pacific Connective Tissue Societies Symposium, PPCTSS 2013en_US
dc.titleGli-mediated regulation of Sox9 in limb developmenten_US
dc.typeConference_Paperen_US
dc.identifier.emailWu, MH: ronmhwu@hkucc.hku.hken_US
dc.identifier.emailHui, CC: cchuilab@hku.hken_US
dc.identifier.emailChan, D: chand@hku.hken_US
dc.identifier.emailCheah, KSE: hrmbdkc@hku.hken_US
dc.identifier.emailCheung, MCH: mcheung9@hku.hk-
dc.identifier.authorityChan, D=rp00540en_US
dc.identifier.authorityCheah, KSE=rp00342en_US
dc.identifier.hkuros240470en_US

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