File Download

Conference Paper: Roles of a novel splice variant of human IFI16 in innate immune response

TitleRoles of a novel splice variant of human IFI16 in innate immune response
Authors
Issue Date2014
Citation
The 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 44, poster no. 58 How to Cite?
AbstractDNA from viral or bacterial pathogens activates innate immune response. The recognition of self-DNA would induce autoimmune diseases such as systemic lupus erythematosus (SLE). In human, AIM2 like receptors (ALRs) including AIM2, IFI16, IFIX and MNDA are DNA binding proteins implicated in DNA sensing. Most ALRs contain an N-terminal pyrin domain and C-terminal HIN200 domains. However, mouse SLE susceptibility locus p202 encodes only HIN200 domains. A human homolog of p202 was not found. Here, we identified and characterized a novel splice variant of human IFI16, which has a similar domain structure as mouse p202. We named it ...
DescriptionPoster presentation - Theme 4: Infection & immunity
Persistent Identifierhttp://hdl.handle.net/10722/203872

 

DC FieldValueLanguage
dc.contributor.authorWang, Pen_US
dc.contributor.authorSiu, KLen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorYang, Wen_US
dc.contributor.authorKok, KHen_US
dc.contributor.authorJin, Den_US
dc.date.accessioned2014-09-19T16:42:28Z-
dc.date.available2014-09-19T16:42:28Z-
dc.date.issued2014en_US
dc.identifier.citationThe 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 44, poster no. 58en_US
dc.identifier.urihttp://hdl.handle.net/10722/203872-
dc.descriptionPoster presentation - Theme 4: Infection & immunity-
dc.description.abstractDNA from viral or bacterial pathogens activates innate immune response. The recognition of self-DNA would induce autoimmune diseases such as systemic lupus erythematosus (SLE). In human, AIM2 like receptors (ALRs) including AIM2, IFI16, IFIX and MNDA are DNA binding proteins implicated in DNA sensing. Most ALRs contain an N-terminal pyrin domain and C-terminal HIN200 domains. However, mouse SLE susceptibility locus p202 encodes only HIN200 domains. A human homolog of p202 was not found. Here, we identified and characterized a novel splice variant of human IFI16, which has a similar domain structure as mouse p202. We named it ...-
dc.languageengen_US
dc.relation.ispartofHong Kong Inter-University Biochemistry Postgraduate Symposiumen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleRoles of a novel splice variant of human IFI16 in innate immune responseen_US
dc.typeConference_Paperen_US
dc.identifier.emailSiu, KL: sklsfx@hkucc.hku.hken_US
dc.identifier.emailZhang, Y: yannizy@hku.hken_US
dc.identifier.emailYang, W: yangwl@hkucc.hku.hken_US
dc.identifier.emailKok, KH: khkok@hku.hken_US
dc.identifier.emailJin, D: dyjin@hku.hken_US
dc.identifier.authorityYang, W=rp00524en_US
dc.identifier.authorityKok, KH=rp01455en_US
dc.identifier.authorityJin, D=rp00452en_US
dc.description.naturepostprint-
dc.identifier.hkuros240404en_US
dc.identifier.spage44, poster no. 58-
dc.identifier.epage44, poster no. 58-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats