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Conference Paper: The enzymatic mechanism mediating the breakdown of glycogen in hypoxic tumor cells

TitleThe enzymatic mechanism mediating the breakdown of glycogen in hypoxic tumor cells
Authors
Issue Date2014
Citation
The 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 30, abstract no. 35 How to Cite?
AbstractGlycogen has been recently implicated as a major source of metabolic fuel for hypoxic tumor cells. The biochemical mechanism underlying the breakdown of glycogen to produce the substrate for glycolysis though is not fully understood. The aim of this study is to demonstrate the potential role of glycogen phosphorylase or α-glucosidase in mediating breakdown of intracellular glycogen in hypoxic tumor cells. The deprivation of glucose in normoxic tumor cells over a period of 6 hours resulted in marked reduction of intracellular glycogen level. Imposing hypoxia (1% O2) on these cells during ...
DescriptionPoster presentation - Theme 2: Cancer & other diseases
Persistent Identifierhttp://hdl.handle.net/10722/203857

 

DC FieldValueLanguage
dc.contributor.authorMung, KLen_US
dc.contributor.authorWong, NSen_US
dc.date.accessioned2014-09-19T16:42:20Z-
dc.date.available2014-09-19T16:42:20Z-
dc.date.issued2014en_US
dc.identifier.citationThe 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 30, abstract no. 35en_US
dc.identifier.urihttp://hdl.handle.net/10722/203857-
dc.descriptionPoster presentation - Theme 2: Cancer & other diseases-
dc.description.abstractGlycogen has been recently implicated as a major source of metabolic fuel for hypoxic tumor cells. The biochemical mechanism underlying the breakdown of glycogen to produce the substrate for glycolysis though is not fully understood. The aim of this study is to demonstrate the potential role of glycogen phosphorylase or α-glucosidase in mediating breakdown of intracellular glycogen in hypoxic tumor cells. The deprivation of glucose in normoxic tumor cells over a period of 6 hours resulted in marked reduction of intracellular glycogen level. Imposing hypoxia (1% O2) on these cells during ...-
dc.languageengen_US
dc.relation.ispartofHong Kong Inter-University Biochemistry Postgraduate Symposium 2014en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleThe enzymatic mechanism mediating the breakdown of glycogen in hypoxic tumor cellsen_US
dc.typeConference_Paperen_US
dc.identifier.emailWong, NS: nswong@hku.hken_US
dc.identifier.authorityWong, NS=rp00340en_US
dc.description.naturepostprint-
dc.identifier.hkuros240364en_US
dc.identifier.spage30, abstract no. 35-
dc.identifier.epage30, abstract no. 35-

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