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Conference Paper: Eya1 is essential for branchial arch segmentation and branchial epithelium development through regulating Notch signaling pathway

TitleEya1 is essential for branchial arch segmentation and branchial epithelium development through regulating Notch signaling pathway
Authors
Issue Date2014
Citation
The 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 11 How to Cite?
AbstractCraniofacial anomalies are common features of Branchio-Oto-Renal (BOR) syndrome patients. Mutations in the Eya1 gene have been found in around half of the BOR patients, but the pathogenic mechanisms mediated by Eya1 in the craniofacial malformations remain unknown. In this study, we use Eya1 mutant mice as a disease model to study the abnormal early branchial arch (BA) development. Eya1-/- mutant embryos have hypoplastic BA2. The formation of branchial cleft was severely affected. Interestingly, Notch signaling was down-regulated in the mutant branchial ...
DescriptionStudent Oral Presentation Session 3
Persistent Identifierhttp://hdl.handle.net/10722/203832

 

DC FieldValueLanguage
dc.contributor.authorZhang, Hen_US
dc.contributor.authorSham, MHen_US
dc.date.accessioned2014-09-19T16:41:15Z-
dc.date.available2014-09-19T16:41:15Z-
dc.date.issued2014en_US
dc.identifier.citationThe 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 11en_US
dc.identifier.urihttp://hdl.handle.net/10722/203832-
dc.descriptionStudent Oral Presentation Session 3-
dc.description.abstractCraniofacial anomalies are common features of Branchio-Oto-Renal (BOR) syndrome patients. Mutations in the Eya1 gene have been found in around half of the BOR patients, but the pathogenic mechanisms mediated by Eya1 in the craniofacial malformations remain unknown. In this study, we use Eya1 mutant mice as a disease model to study the abnormal early branchial arch (BA) development. Eya1-/- mutant embryos have hypoplastic BA2. The formation of branchial cleft was severely affected. Interestingly, Notch signaling was down-regulated in the mutant branchial ...-
dc.languageengen_US
dc.relation.ispartofHong Kong Inter-University Biochemistry Postgraduate Symposium 2014en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleEya1 is essential for branchial arch segmentation and branchial epithelium development through regulating Notch signaling pathwayen_US
dc.typeConference_Paperen_US
dc.identifier.emailSham, MH: mhsham@hku.hken_US
dc.identifier.authoritySham, MH=rp00380en_US
dc.description.naturepostprint-
dc.identifier.hkuros240239en_US
dc.identifier.hkuros270426-
dc.identifier.spage11-
dc.identifier.epage11-

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