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Article: Effect of berberine on insulin resistance in women with polycystic ovary syndrome: study protocol for a randomized multicenter controlled trial.

TitleEffect of berberine on insulin resistance in women with polycystic ovary syndrome: study protocol for a randomized multicenter controlled trial.
Authors
Issue Date2013
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.trialsjournal.com/
Citation
Trials , 2013, v. 14, article no. 226 How to Cite?
AbstractBACKGROUND: Insulin resistance and hyperinsulinemia play a key role in the pathogenesis of polycystic ovary syndrome (PCOS), which is characterized by hyperandrogenism, ovulatory dysfunction, and presence of polycystic ovaries on pelvic scanning. Insulin resistance is significantly associated with the long-term risks of metabolic syndrome and cardiovascular disease. Berberine has effects on insulin resistance but its use in women with PCOS has not been fully investigated. In this paper, we present a research design evaluating the effects of berberine on insulin resistance in women with PCOS. METHODS/DESIGN: This is a multicenter, randomized, placebo-controlled and double-blind trial. A total of 120 patients will be enrolled in this study and will be randomized into two groups. Berberine or placebo will be taken orally for 12 weeks. The primary outcome is the whole body insulin action assessed with the hyperinsulinemic-euglycemic clamp. DISCUSSION: We postulate that women with PCOS will have improved insulin resistance following berberine administration. TRIAL REGISTRATION: This study is registered at ClinicalTrials.gov, NCT01138930.
Persistent Identifierhttp://hdl.handle.net/10722/203604
ISSN
2015 Impact Factor: 1.859
2015 SCImago Journal Rankings: 1.077
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Yen_US
dc.contributor.authorMa, Hen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorKuang, Hen_US
dc.contributor.authorNg, EHYen_US
dc.contributor.authorHou, Len_US
dc.contributor.authorWu, Xen_US
dc.date.accessioned2014-09-19T15:32:27Z-
dc.date.available2014-09-19T15:32:27Z-
dc.date.issued2013en_US
dc.identifier.citationTrials , 2013, v. 14, article no. 226en_US
dc.identifier.issn1745-6215-
dc.identifier.urihttp://hdl.handle.net/10722/203604-
dc.description.abstractBACKGROUND: Insulin resistance and hyperinsulinemia play a key role in the pathogenesis of polycystic ovary syndrome (PCOS), which is characterized by hyperandrogenism, ovulatory dysfunction, and presence of polycystic ovaries on pelvic scanning. Insulin resistance is significantly associated with the long-term risks of metabolic syndrome and cardiovascular disease. Berberine has effects on insulin resistance but its use in women with PCOS has not been fully investigated. In this paper, we present a research design evaluating the effects of berberine on insulin resistance in women with PCOS. METHODS/DESIGN: This is a multicenter, randomized, placebo-controlled and double-blind trial. A total of 120 patients will be enrolled in this study and will be randomized into two groups. Berberine or placebo will be taken orally for 12 weeks. The primary outcome is the whole body insulin action assessed with the hyperinsulinemic-euglycemic clamp. DISCUSSION: We postulate that women with PCOS will have improved insulin resistance following berberine administration. TRIAL REGISTRATION: This study is registered at ClinicalTrials.gov, NCT01138930.-
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.trialsjournal.com/-
dc.relation.ispartofTrialsen_US
dc.rightsTrials . Copyright © BioMed Central Ltd.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshBerberine - administration and dosage - adverse effects - therapeutic use-
dc.subject.meshBlood Glucose - drug effects - metabolism-
dc.subject.meshHypoglycemic Agents - administration and dosage - adverse effects - therapeutic use-
dc.subject.meshInsulin Resistance-
dc.subject.meshPolycystic Ovary Syndrome - blood - diagnosis - drug therapy - physiopathology-
dc.titleEffect of berberine on insulin resistance in women with polycystic ovary syndrome: study protocol for a randomized multicenter controlled trial.en_US
dc.typeArticleen_US
dc.identifier.emailNg, EHY: nghye@hku.hken_US
dc.identifier.authorityNg, EHY=rp00426en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1745-6215-14-226-
dc.identifier.pmid23866924-
dc.identifier.pmcidPMC3722087-
dc.identifier.hkuros238657en_US
dc.identifier.volume14en_US
dc.identifier.isiWOS:000322190700001-
dc.publisher.placeUnited Kingdom-

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