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Article: Acute effects of inhaled sulphur dioxide on pig nasal vascular and airway resistances

TitleAcute effects of inhaled sulphur dioxide on pig nasal vascular and airway resistances
Authors
Issue Date2014
PublisherScience Press. The Journal's web site is located at http://www.actaps.com.cn
Citation
Acta Physiologica Sinica, 2014, v. 66 n. 1, p. 79-84 How to Cite?
AbstractPeople complain about nasal stuffiness after SO2 exposure. This study was to investigate the acute effects of SO2 on nasal vascular and airway resistances in anaesthetized pigs for elucidating the underlying vascular and control mechanisms. Controlled ventilation was passed to the lungs or retrogradely through each nasal cavity. Nasal airway and lower airway pressures were measured to reflect airflow resistance changes. Systemic arterial pressure and nasal arterial flow were measured to calculate nasal vascular resistance. Nasal and pulmonary SO2 challenges were given. At 2 ppm, SO2 decreased systemic blood pressure and nasal vascular resistance but increased nasal airway and lower airway resistances. With increasing level to 8 ppm, SO2 increased systemic arterial pressure, nasal vascular and lower airway resistances but decreased nasal airway resistance. Nasal and pulmonary challenges induced similar responses. Ipsilateral nasal challenge elicited bilateral responses. Ruthenium red abolished the responses to nasal challenges. Bilateral vagosympathectomy eliminated the responses to lung challenges. Hence, SO2 at 2 ppm causes nasal congestion through sensory reflex vasodilatation but at higher levels nasal decongestion through sensory reflex vasoconstriction. Nasal congestion coupled with bronchoconstriction at levels of SO2 below short-term exposure limit (STEL) ( 2 ppm) can effectively decrease total airway resistance as concurrent strong bronchoconstriction may impair ventilation.
Persistent Identifierhttp://hdl.handle.net/10722/203331
ISSN
2015 SCImago Journal Rankings: 0.240

 

DC FieldValueLanguage
dc.contributor.authorLung, MAKYen_US
dc.date.accessioned2014-09-19T14:08:55Z-
dc.date.available2014-09-19T14:08:55Z-
dc.date.issued2014en_US
dc.identifier.citationActa Physiologica Sinica, 2014, v. 66 n. 1, p. 79-84en_US
dc.identifier.issn0371-0874-
dc.identifier.urihttp://hdl.handle.net/10722/203331-
dc.description.abstractPeople complain about nasal stuffiness after SO2 exposure. This study was to investigate the acute effects of SO2 on nasal vascular and airway resistances in anaesthetized pigs for elucidating the underlying vascular and control mechanisms. Controlled ventilation was passed to the lungs or retrogradely through each nasal cavity. Nasal airway and lower airway pressures were measured to reflect airflow resistance changes. Systemic arterial pressure and nasal arterial flow were measured to calculate nasal vascular resistance. Nasal and pulmonary SO2 challenges were given. At 2 ppm, SO2 decreased systemic blood pressure and nasal vascular resistance but increased nasal airway and lower airway resistances. With increasing level to 8 ppm, SO2 increased systemic arterial pressure, nasal vascular and lower airway resistances but decreased nasal airway resistance. Nasal and pulmonary challenges induced similar responses. Ipsilateral nasal challenge elicited bilateral responses. Ruthenium red abolished the responses to nasal challenges. Bilateral vagosympathectomy eliminated the responses to lung challenges. Hence, SO2 at 2 ppm causes nasal congestion through sensory reflex vasodilatation but at higher levels nasal decongestion through sensory reflex vasoconstriction. Nasal congestion coupled with bronchoconstriction at levels of SO2 below short-term exposure limit (STEL) (</= 2 ppm) would limit SO2 entering the lungs. Nasal decongestion at levels of SO2 beyond STEL (> 2 ppm) can effectively decrease total airway resistance as concurrent strong bronchoconstriction may impair ventilation.-
dc.languageengen_US
dc.publisherScience Press. The Journal's web site is located at http://www.actaps.com.cnen_US
dc.relation.ispartofActa Physiologica Sinicaen_US
dc.titleAcute effects of inhaled sulphur dioxide on pig nasal vascular and airway resistancesen_US
dc.typeArticleen_US
dc.identifier.emailLung, MAKY: makylung@hkucc.hku.hken_US
dc.identifier.authorityLung, MAKY=rp00319en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.13294/j.aps.2014.0010-
dc.identifier.pmid24553872-
dc.identifier.hkuros236869en_US
dc.identifier.volume66en_US
dc.identifier.issue1-
dc.identifier.spage79en_US
dc.identifier.epage84en_US
dc.publisher.placeChinaen_US

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