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Article: Strontium exerts dual effects on calcium phosphate cement: accelerating the degradation and enhancing the osteoconductivity both in vitro and in vivo

TitleStrontium exerts dual effects on calcium phosphate cement: accelerating the degradation and enhancing the osteoconductivity both in vitro and in vivo
Authors
Issue Date2015
PublisherWiley.
Citation
The Journal of Biomedical Materials Research Part A, 2015, v. 103 n. 5, p. 1613-1621 How to Cite?
AbstractCalcium phosphate cements (CPCs) have long been used as osteoconductive bone substitutes in the treatment of bone defects. However, the degradation rate of CPC is typi- cally too slow to match the new bone growth rate. It is known that strontium increases the solubility of hydroxyapa- tite as well as exerts both anabolic and anticatabolic effects on bone. Therefore, we hypothesized that the incorporation of strontium would accelerate the degradation rate and enhance the osteoconductivity of CPC. In this study, Three groups, CPC (0% Sr-CPC), 5% Sr-CPC, and 10% Sr-CPC, were prepared, with the total molar ratio for Sr/(Sr1Ca) in the cement powder phase being 0, 5, and 10%, respectively. In the immersion test, less residual weight was observed in both 5% Sr-CPC and 10% Sr-CPC groups than CPC group. In addition, a higher osteoblastic cell proliferation rate and alka- line phosphatase activity were obtained in the strontium groups. In a rat femur bone defect model comparing CPC with 10% Sr-CPC, at 2 weeks postoperation, early endochon- dral ossification was found in the 10% Sr-CPC group, whereas only fibrous tissue was observed in control group; at 4–16 weeks postoperation, progressive osteoconduction toward the cement was observed in both groups. At 32 weeks, a higher peri-cement bone area and reduced cement area were noted in the 10% Sr-CPC group. In conclusion, in the 10% Sr-CPC group, strontium exerts dual effects on CPC: accelerating degradation rate and enhancing osteoconductiv- ity, as shown here both in vitro and in vivo.
Persistent Identifierhttp://hdl.handle.net/10722/203191

 

DC FieldValueLanguage
dc.contributor.authorKuang, Gen_US
dc.contributor.authorYau, WPen_US
dc.contributor.authorWu, Jen_US
dc.contributor.authorYeung, KWKen_US
dc.contributor.authorPan, Hen_US
dc.contributor.authorLu, WWen_US
dc.contributor.authorChiu, PKYen_US
dc.date.accessioned2014-09-19T13:08:29Z-
dc.date.available2014-09-19T13:08:29Z-
dc.date.issued2015-
dc.identifier.citationThe Journal of Biomedical Materials Research Part A, 2015, v. 103 n. 5, p. 1613-1621en_US
dc.identifier.urihttp://hdl.handle.net/10722/203191-
dc.description.abstractCalcium phosphate cements (CPCs) have long been used as osteoconductive bone substitutes in the treatment of bone defects. However, the degradation rate of CPC is typi- cally too slow to match the new bone growth rate. It is known that strontium increases the solubility of hydroxyapa- tite as well as exerts both anabolic and anticatabolic effects on bone. Therefore, we hypothesized that the incorporation of strontium would accelerate the degradation rate and enhance the osteoconductivity of CPC. In this study, Three groups, CPC (0% Sr-CPC), 5% Sr-CPC, and 10% Sr-CPC, were prepared, with the total molar ratio for Sr/(Sr1Ca) in the cement powder phase being 0, 5, and 10%, respectively. In the immersion test, less residual weight was observed in both 5% Sr-CPC and 10% Sr-CPC groups than CPC group. In addition, a higher osteoblastic cell proliferation rate and alka- line phosphatase activity were obtained in the strontium groups. In a rat femur bone defect model comparing CPC with 10% Sr-CPC, at 2 weeks postoperation, early endochon- dral ossification was found in the 10% Sr-CPC group, whereas only fibrous tissue was observed in control group; at 4–16 weeks postoperation, progressive osteoconduction toward the cement was observed in both groups. At 32 weeks, a higher peri-cement bone area and reduced cement area were noted in the 10% Sr-CPC group. In conclusion, in the 10% Sr-CPC group, strontium exerts dual effects on CPC: accelerating degradation rate and enhancing osteoconductiv- ity, as shown here both in vitro and in vivo.en_US
dc.languageengen_US
dc.publisherWiley.en_US
dc.relation.ispartofThe Journal of Biomedical Materials Research Part Aen_US
dc.titleStrontium exerts dual effects on calcium phosphate cement: accelerating the degradation and enhancing the osteoconductivity both in vitro and in vivoen_US
dc.typeArticleen_US
dc.identifier.emailKuang, G: kuanggm@connect.hku.hken_US
dc.identifier.emailYau, WP: peterwpy@hkucc.hku.hken_US
dc.identifier.emailWu, J: wujun@hku.hken_US
dc.identifier.emailYeung, KWK: wkkyeung@hku.hken_US
dc.identifier.emailPan, H: haobo@hku.hken_US
dc.identifier.emailLu, WW: wwlu@hku.hken_US
dc.identifier.emailChiu, PKY: pkychiu@hkucc.hku.hken_US
dc.identifier.authorityYau, WP=rp00500en_US
dc.identifier.authorityYeung, KWK=rp00309en_US
dc.identifier.authorityPan, H=rp01564en_US
dc.identifier.authorityLu, WW=rp00411en_US
dc.identifier.authorityChiu, PKY=rp00379en_US
dc.identifier.doi10.1002/jbm.a.35298-
dc.identifier.hkuros236653en_US

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