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Article: Meta-analysis Of Genome-wide Association Studies Identifies Two Loci Associated With Circulating Osteoprotegerin Levels.

TitleMeta-analysis Of Genome-wide Association Studies Identifies Two Loci Associated With Circulating Osteoprotegerin Levels.
Authors
Issue Date2015
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
Citation
Human Molecular Genetics, , v. 23 n. 24, p. 6684-6693 How to Cite?
AbstractOsteoprotegerin (OPG) is involved in bone homeostasis and tumor cell survival. Circulating OPG levels are also important biomarkers of various clinical traits, such as cancers and atherosclerosis. OPG levels were measured in serum or in plasma. In a meta-analysis of genome-wide association studies in up to 10 336 individuals from European and Asian origin, we discovered that variants >100 kb upstream of the TNFRSF11B gene encoding OPG and another new locus on chromosome 17q11.2 were significantly associated with OPG variation. We also identified a suggestive locus on chromosome 14q21.2 associated with the trait. Moreover, we estimated that over half of the heritability of OPG levels could be explained by all variants examined in our study. Our findings provide further insight into the genetic regulation of circulating OPG levels.
Persistent Identifierhttp://hdl.handle.net/10722/203062
ISSN
2015 Impact Factor: 5.985
2015 SCImago Journal Rankings: 4.288
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwan, SH-
dc.contributor.authorHsu, YH-
dc.contributor.authorCheung, CL-
dc.contributor.authorDupuis, J-
dc.contributor.authorSaint-Pierre, A-
dc.contributor.authorEriksson, J-
dc.contributor.authorHandelman, SK-
dc.contributor.authorAragaki, A-
dc.contributor.authorKarasik, D-
dc.contributor.authorPramstaller, PP-
dc.contributor.authorKooperberg, C-
dc.contributor.authorLacroix, AZ-
dc.contributor.authorLarson, MG-
dc.contributor.authorLau, KS-
dc.contributor.authorLorentzon, M-
dc.contributor.authorPichler, I-
dc.contributor.authorSham, PC-
dc.contributor.authorTaliun, D-
dc.contributor.authorVandenput, L-
dc.contributor.authorKiel, DP-
dc.date.accessioned2014-09-19T11:29:24Z-
dc.date.available2014-09-19T11:29:24Z-
dc.date.issued2015-
dc.identifier.citationHuman Molecular Genetics, , v. 23 n. 24, p. 6684-6693-
dc.identifier.issn0964-6906-
dc.identifier.urihttp://hdl.handle.net/10722/203062-
dc.description.abstractOsteoprotegerin (OPG) is involved in bone homeostasis and tumor cell survival. Circulating OPG levels are also important biomarkers of various clinical traits, such as cancers and atherosclerosis. OPG levels were measured in serum or in plasma. In a meta-analysis of genome-wide association studies in up to 10 336 individuals from European and Asian origin, we discovered that variants >100 kb upstream of the TNFRSF11B gene encoding OPG and another new locus on chromosome 17q11.2 were significantly associated with OPG variation. We also identified a suggestive locus on chromosome 14q21.2 associated with the trait. Moreover, we estimated that over half of the heritability of OPG levels could be explained by all variants examined in our study. Our findings provide further insight into the genetic regulation of circulating OPG levels.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/-
dc.relation.ispartofHuman Molecular Genetics-
dc.titleMeta-analysis Of Genome-wide Association Studies Identifies Two Loci Associated With Circulating Osteoprotegerin Levels.-
dc.typeArticle-
dc.identifier.emailKwan, SH: shkwan@hku.hk-
dc.identifier.emailCheung, CL: lung1212@hku.hk-
dc.identifier.emailLau, KS: kslau@hku.hk-
dc.identifier.emailSham, PC: pcsham@hku.hk-
dc.identifier.authorityCheung, CL=rp01749-
dc.identifier.authoritySham, PC=rp00459-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/hmg/ddu386-
dc.identifier.pmid25080503-
dc.identifier.pmcidPMC4240210-
dc.identifier.scopuseid_2-s2.0-84936776293-
dc.identifier.hkuros235556-
dc.identifier.volume23-
dc.identifier.issue24-
dc.identifier.spage6684-
dc.identifier.epage6693-
dc.identifier.isiWOS:000347921900023-
dc.publisher.placeUnited Kingdom-

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