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Conference Paper: Modulating drug release kinetics of PLGA microspheres by fabricating PLGA-alginate core-shell drug delivery devices with microfluidic method

TitleModulating drug release kinetics of PLGA microspheres by fabricating PLGA-alginate core-shell drug delivery devices with microfluidic method
Authors
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-TERM.html
Citation
The 3rd TERMIS World Congress, Vienna, Austria, 5-8 September 2012. In Journal of Tissue Engineering and Regenerative Medicine, 2012, v. 6 suppl. 1, p. 327, abstract no. 54.P19 How to Cite?
AbstractControlled drug delivery devices offer numerous advantages compared with conventional drugs. Among all the devices, PLGA microspheres are of particular interests for biocompatibility, biodegradability and easy administration. However, control of the drug release kinetics is still a major challenge due to the complex release mechanisms [1]. Recently, near zero order release were observed from PLGA microspheres / alginate beads composite devices [2]. However, such structure eliminated the easy administration property. In this study, PLGAalginate core-shell devices were developed by microfluidic method to modulate the drug release kinetics while keeping the microspheric geometry. PLGA-alginate core-shell devices were fabricated by O/W/O emulsion systems utilizing capillary microfluidic devices [3]. The resultants were characterized by SEM, microscopy, in vitro release test and MTT assay. The core-shell structure was confirmed by SEM and microscopy. The drug release kinetics of PLGA microspheres were significantly modulated by the shell layer. Initial burst was suppressed and a near zero order release was achieved when the shell layer was saturated with released drug. PLGA-alginate core-shell devices were biocompatible and may be promising tools for controlled drug delivery. References: 1. A. R. Ahmed et al. Eur.J.Pharm.Biopharm. 2008. 70 765–769. 2. R. H. Ranganath et al. Pharm.Res. 2009. 26 2101–2114. 3. H. C. Shum et al. J.A.C.S. 2008. 130 9543–9549.
Persistent Identifierhttp://hdl.handle.net/10722/203044
ISSN
2015 Impact Factor: 4.71
2015 SCImago Journal Rankings: 0.920

 

DC FieldValueLanguage
dc.contributor.authorWu, Jen_US
dc.contributor.authorKong, TTen_US
dc.contributor.authorTo, MKTen_US
dc.contributor.authorShum, AHCen_US
dc.contributor.authorWang, LQen_US
dc.contributor.authorYeung, KWKen_US
dc.date.accessioned2014-09-19T11:08:44Z-
dc.date.available2014-09-19T11:08:44Z-
dc.date.issued2012en_US
dc.identifier.citationThe 3rd TERMIS World Congress, Vienna, Austria, 5-8 September 2012. In Journal of Tissue Engineering and Regenerative Medicine, 2012, v. 6 suppl. 1, p. 327, abstract no. 54.P19en_US
dc.identifier.issn1932-6254-
dc.identifier.urihttp://hdl.handle.net/10722/203044-
dc.description.abstractControlled drug delivery devices offer numerous advantages compared with conventional drugs. Among all the devices, PLGA microspheres are of particular interests for biocompatibility, biodegradability and easy administration. However, control of the drug release kinetics is still a major challenge due to the complex release mechanisms [1]. Recently, near zero order release were observed from PLGA microspheres / alginate beads composite devices [2]. However, such structure eliminated the easy administration property. In this study, PLGAalginate core-shell devices were developed by microfluidic method to modulate the drug release kinetics while keeping the microspheric geometry. PLGA-alginate core-shell devices were fabricated by O/W/O emulsion systems utilizing capillary microfluidic devices [3]. The resultants were characterized by SEM, microscopy, in vitro release test and MTT assay. The core-shell structure was confirmed by SEM and microscopy. The drug release kinetics of PLGA microspheres were significantly modulated by the shell layer. Initial burst was suppressed and a near zero order release was achieved when the shell layer was saturated with released drug. PLGA-alginate core-shell devices were biocompatible and may be promising tools for controlled drug delivery. References: 1. A. R. Ahmed et al. Eur.J.Pharm.Biopharm. 2008. 70 765–769. 2. R. H. Ranganath et al. Pharm.Res. 2009. 26 2101–2114. 3. H. C. Shum et al. J.A.C.S. 2008. 130 9543–9549.-
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-TERM.html-
dc.relation.ispartofJournal of Tissue Engineering and Regenerative Medicineen_US
dc.rightsJournal of Tissue Engineering and Regenerative Medicine. Copyright © John Wiley & Sons, Inc.-
dc.titleModulating drug release kinetics of PLGA microspheres by fabricating PLGA-alginate core-shell drug delivery devices with microfluidic methoden_US
dc.typeConference_Paperen_US
dc.identifier.emailKong, TT: ttkong@hku.hken_US
dc.identifier.emailTo, MKT: mikektto@hku.hken_US
dc.identifier.emailShum, AHC: ashum@hku.hken_US
dc.identifier.emailWang, LQ: lqwang@hku.hken_US
dc.identifier.emailYeung, KWK: wkkyeung@hku.hken_US
dc.identifier.authorityTo, MKT=rp00302en_US
dc.identifier.authorityShum, AHC=rp01439en_US
dc.identifier.authorityWang, LQ=rp00184en_US
dc.identifier.authorityYeung, KWK=rp00309en_US
dc.identifier.doi10.1002/term.1586-
dc.identifier.hkuros240093en_US
dc.identifier.hkuros208098-
dc.identifier.volume6 suppl. 1en_US
dc.identifier.spage327, abstract no. 54.P19en_US
dc.identifier.epage327, abstract no. 54.P19en_US
dc.publisher.placeUnited States-

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