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Article: Water-Soluble Luminescent Cyclometalated Gold(III) Complexes with cis-Chelating Bis(N-Heterocyclic Carbene) Ligands: Synthesis and Photophysical Properties

TitleWater-Soluble Luminescent Cyclometalated Gold(III) Complexes with cis-Chelating Bis(N-Heterocyclic Carbene) Ligands: Synthesis and Photophysical Properties
Authors
Issue Date2014
PublisherWiley-VCH.
Citation
Chemistry - A European Journal, 2014, v. 20 n. 28, p. 8604–8614 How to Cite?
AbstractA new class of cyclometalated AuIII complexes containing various bidentate C-deprotonated C^N and cis-chelating bis(N-heterocyclic carbene) (bis-NHC) ligands has been synthesized and characterized. These are the first examples of AuIII complexes supported by cis-chelating bis-NHC ligands. [Au(C^N)(bis-NHC)] complexes display emission in solutions under degassed condition at room temperature with emission maxima (λmax) at 498–633 nm and emission quantum yields of up to 10.1 %. The emissions are assigned to triplet intraligand (IL) π->π* transitions of C^N ligands. The AuIII complex containing a C^N (C-deprotonated naphthalene-substituted quinoline) ligand with extended π-conjugation exhibits prompt fluorescence and phosphorescence of comparable intensity with λmax at 454 and 611 nm respectively. With sulfonate-functionalized bis-NHC ligand, four water-soluble luminescent AuIII complexes, including those displaying both fluorescence and phosphorescence, were prepared. They show similar photophysical properties in water when compared with their counterparts in acetonitrile. The long phosphorescence lifetime of the water-soluble AuIII complex with C-deprotonated naphthalene-substituted quinoline ligand renders it to function as ratiometric sensor for oxygen. Inhibitory activity of one of these water-soluble AuIII complexes towards deubiquitinase (DUB) UCHL3 has been investigated; this complex also displayed a significant inhibitory activity with IC50 value of 0.15 μM.
Persistent Identifierhttp://hdl.handle.net/10722/202595
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHUNG, FFen_US
dc.contributor.authorTo, WPen_US
dc.contributor.authorZHANG, Jen_US
dc.contributor.authorMa, Cen_US
dc.contributor.authorWong, WYen_US
dc.contributor.authorChe, CMen_US
dc.date.accessioned2014-09-19T08:42:10Z-
dc.date.available2014-09-19T08:42:10Z-
dc.date.issued2014en_US
dc.identifier.citationChemistry - A European Journal, 2014, v. 20 n. 28, p. 8604–8614en_US
dc.identifier.urihttp://hdl.handle.net/10722/202595-
dc.description.abstractA new class of cyclometalated AuIII complexes containing various bidentate C-deprotonated C^N and cis-chelating bis(N-heterocyclic carbene) (bis-NHC) ligands has been synthesized and characterized. These are the first examples of AuIII complexes supported by cis-chelating bis-NHC ligands. [Au(C^N)(bis-NHC)] complexes display emission in solutions under degassed condition at room temperature with emission maxima (λmax) at 498–633 nm and emission quantum yields of up to 10.1 %. The emissions are assigned to triplet intraligand (IL) π->π* transitions of C^N ligands. The AuIII complex containing a C^N (C-deprotonated naphthalene-substituted quinoline) ligand with extended π-conjugation exhibits prompt fluorescence and phosphorescence of comparable intensity with λmax at 454 and 611 nm respectively. With sulfonate-functionalized bis-NHC ligand, four water-soluble luminescent AuIII complexes, including those displaying both fluorescence and phosphorescence, were prepared. They show similar photophysical properties in water when compared with their counterparts in acetonitrile. The long phosphorescence lifetime of the water-soluble AuIII complex with C-deprotonated naphthalene-substituted quinoline ligand renders it to function as ratiometric sensor for oxygen. Inhibitory activity of one of these water-soluble AuIII complexes towards deubiquitinase (DUB) UCHL3 has been investigated; this complex also displayed a significant inhibitory activity with IC50 value of 0.15 μM.en_US
dc.languageengen_US
dc.publisherWiley-VCH.en_US
dc.relation.ispartofChemistry - A European Journalen_US
dc.titleWater-Soluble Luminescent Cyclometalated Gold(III) Complexes with cis-Chelating Bis(N-Heterocyclic Carbene) Ligands: Synthesis and Photophysical Propertiesen_US
dc.typeArticleen_US
dc.identifier.emailTo, WP: kevintwp@hku.hken_US
dc.identifier.emailMa, C: macs@hku.hken_US
dc.identifier.emailChe, CM: cmche@hku.hken_US
dc.identifier.authorityMa, C=rp00758en_US
dc.identifier.doi10.1002/chem.201403103en_US
dc.identifier.pmid24957269-
dc.identifier.hkuros238300en_US
dc.identifier.volume20en_US
dc.identifier.spage8604en_US
dc.identifier.epage8614en_US
dc.identifier.isiWOS:000338768900017-
dc.publisher.placeGermanyen_US

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