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Article: Combination of MRI hippocampal volumetry and arterial spin labeling MR perfusion at 3-Tesla improves the efficacy in discriminating Alzheimer's disease from cognitively normal elderly adults

TitleCombination of MRI hippocampal volumetry and arterial spin labeling MR perfusion at 3-Tesla improves the efficacy in discriminating Alzheimer's disease from cognitively normal elderly adults
Authors
Issue Date2014
PublisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.php
Citation
Journal of Alzheimer's Disease, 2014, v. 41, p. 749-758 How to Cite?
AbstractBACKGROUND: Structural magnetic resonance imaging has been employed for evaluation of medial temporal atrophy in patients with Alzheimer's disease (AD). Arterial spin labeling (ASL) technique could detect cerebral perfusion abnormalities in AD. OBJECTIVE: We hypothesized that combination of hippocampal volumetry and cerebral blood flow yield higher accuracy than either method alone in discriminating AD patients from cognitively normal elderly adults. MATERIALS AND METHODS: 13 AD patients and 15 healthy controls were studied using a 3-tesla scanner. Standardized T1W 3D volumetric Fast Field Echo and QUASAR ASL sequences were employed for cerebral volumetry and perfusion respectively. Manual Right and left hippocampal volumetry was performed manually by ANALYZE software, with total intracranial volume normalization. ASL data were analyzed by institutional specially-design software to calculate cerebral blood flow of region-of-interests placed at the middle and posterior cingulate gyri. RESULTS: Right and left hippocampal volumes and middle and posterior cingulate gyri cerebral blood flows were significantly lower in the patients than in the controls (independent-samples t-tests, p < 0.05), and prediction accuracies of 89.3%, 82.1%, 75.0% and 71.4% were achieved for each of the above parameters, respectively. In distinguishing patients from controls using corresponding optimized cut-off values, various combinations of these parameters were used to create the Receiver Operating Characteristic curves. The highest area under curve value was 0.944, by combining cerebral blood flow at the middle cingulate gyrus, normalized right and left hippocampal volumes. CONCLUSIONS: A 'one-stop-shop' magnetic resonance study of combined hippocampal volumetry and cerebral perfusion has improved efficacy in discriminating AD patients from cognitively normal elderly adults.
Persistent Identifierhttp://hdl.handle.net/10722/202524
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMak, HKFen_US
dc.contributor.authorQian, Wen_US
dc.contributor.authorNg, KSen_US
dc.contributor.authorChan, Qen_US
dc.contributor.authorSong, Yen_US
dc.contributor.authorChu, LWen_US
dc.contributor.authorYau, KKen_US
dc.date.accessioned2014-09-19T08:25:13Z-
dc.date.available2014-09-19T08:25:13Z-
dc.date.issued2014en_US
dc.identifier.citationJournal of Alzheimer's Disease, 2014, v. 41, p. 749-758en_US
dc.identifier.urihttp://hdl.handle.net/10722/202524-
dc.description.abstractBACKGROUND: Structural magnetic resonance imaging has been employed for evaluation of medial temporal atrophy in patients with Alzheimer's disease (AD). Arterial spin labeling (ASL) technique could detect cerebral perfusion abnormalities in AD. OBJECTIVE: We hypothesized that combination of hippocampal volumetry and cerebral blood flow yield higher accuracy than either method alone in discriminating AD patients from cognitively normal elderly adults. MATERIALS AND METHODS: 13 AD patients and 15 healthy controls were studied using a 3-tesla scanner. Standardized T1W 3D volumetric Fast Field Echo and QUASAR ASL sequences were employed for cerebral volumetry and perfusion respectively. Manual Right and left hippocampal volumetry was performed manually by ANALYZE software, with total intracranial volume normalization. ASL data were analyzed by institutional specially-design software to calculate cerebral blood flow of region-of-interests placed at the middle and posterior cingulate gyri. RESULTS: Right and left hippocampal volumes and middle and posterior cingulate gyri cerebral blood flows were significantly lower in the patients than in the controls (independent-samples t-tests, p < 0.05), and prediction accuracies of 89.3%, 82.1%, 75.0% and 71.4% were achieved for each of the above parameters, respectively. In distinguishing patients from controls using corresponding optimized cut-off values, various combinations of these parameters were used to create the Receiver Operating Characteristic curves. The highest area under curve value was 0.944, by combining cerebral blood flow at the middle cingulate gyrus, normalized right and left hippocampal volumes. CONCLUSIONS: A 'one-stop-shop' magnetic resonance study of combined hippocampal volumetry and cerebral perfusion has improved efficacy in discriminating AD patients from cognitively normal elderly adults.en_US
dc.languageengen_US
dc.publisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.phpen_US
dc.relation.ispartofJournal of Alzheimer's Diseaseen_US
dc.titleCombination of MRI hippocampal volumetry and arterial spin labeling MR perfusion at 3-Tesla improves the efficacy in discriminating Alzheimer's disease from cognitively normal elderly adultsen_US
dc.typeArticleen_US
dc.identifier.emailMak, HKF: makkf@hkucc.hku.hken_US
dc.identifier.emailQian, W: wsqian@hku.hken_US
dc.identifier.emailSong, Y: songy@hku.hken_US
dc.identifier.emailChu, LW: lwchu@hkucc.hku.hken_US
dc.identifier.authorityMak, HKF=rp00533en_US
dc.identifier.authoritySong, Y=rp00488en_US
dc.identifier.doi10.3233/JAD-131868en_US
dc.identifier.pmid24670395-
dc.identifier.hkuros239377en_US
dc.identifier.hkuros235581-
dc.identifier.volume41en_US
dc.identifier.spage749en_US
dc.identifier.epage758en_US
dc.identifier.isiWOS:000339329100012-

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