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Article: Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model

TitlePropofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model
Authors
Issue Date2014
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/oximed/
Citation
Oxidative Medicine and Cellular Longevity, 2014, v. 2014, article no. 258567 How to Cite?
AbstractOBJECTIVE: This study aimed to investigate whether propofol pretreatment can protect against liver transplantation-induced acute lung injury (ALI) and to explore whether Nrf2 pathway is involved in the protections provided by propofol pretreatment. METHOD: Adult male Sprague-Dawley rats were divided into five groups based on the random number table. Lung pathology was observed by optical microscopy. Lung water content was assessed by wet/dry ratio, and PaO2 was detected by blood gas analysis. The contents of H2O2, MDA, and SOD activity were determined by ELISA method, and the expression of HO-1, NQO1, Keap1, and nuclear Nrf2 was assayed by western blotting. RESULTS: Compared with saline-treated model group, both propofol and N-acetylcysteine pretreatment can reduce the acute lung injury caused by orthotopic autologous liver transplantation (OALT), decrease the lung injury scores, lung water content, and H2O2 and MDA levels, and improve the arterial PaO2 and SOD activity. Furthermore, propofol (but not N-acetylcysteine) pretreatment especially in high dose inhibited the expression of Keap1 and induced translocation of Nrf2 into the nucleus to further upregulate the expression of HO-1 and NQO1 downstream. CONCLUSION: Pretreatment with propofol is associated with attenuation of OALT-induced ALI, and the Nrf2 pathway is involved in the antioxidative processes.
Persistent Identifierhttp://hdl.handle.net/10722/202484
ISSN
2015 Impact Factor: 4.492
2015 SCImago Journal Rankings: 1.503
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYao, Wen_US
dc.contributor.authorLuo, Gen_US
dc.contributor.authorZhu, Gen_US
dc.contributor.authorChi, Xen_US
dc.contributor.authorZhang, Aen_US
dc.contributor.authorXia, Zen_US
dc.contributor.authorHei, Zen_US
dc.date.accessioned2014-09-19T07:59:43Z-
dc.date.available2014-09-19T07:59:43Z-
dc.date.issued2014en_US
dc.identifier.citationOxidative Medicine and Cellular Longevity, 2014, v. 2014, article no. 258567en_US
dc.identifier.issn1942-0900-
dc.identifier.urihttp://hdl.handle.net/10722/202484-
dc.description.abstractOBJECTIVE: This study aimed to investigate whether propofol pretreatment can protect against liver transplantation-induced acute lung injury (ALI) and to explore whether Nrf2 pathway is involved in the protections provided by propofol pretreatment. METHOD: Adult male Sprague-Dawley rats were divided into five groups based on the random number table. Lung pathology was observed by optical microscopy. Lung water content was assessed by wet/dry ratio, and PaO2 was detected by blood gas analysis. The contents of H2O2, MDA, and SOD activity were determined by ELISA method, and the expression of HO-1, NQO1, Keap1, and nuclear Nrf2 was assayed by western blotting. RESULTS: Compared with saline-treated model group, both propofol and N-acetylcysteine pretreatment can reduce the acute lung injury caused by orthotopic autologous liver transplantation (OALT), decrease the lung injury scores, lung water content, and H2O2 and MDA levels, and improve the arterial PaO2 and SOD activity. Furthermore, propofol (but not N-acetylcysteine) pretreatment especially in high dose inhibited the expression of Keap1 and induced translocation of Nrf2 into the nucleus to further upregulate the expression of HO-1 and NQO1 downstream. CONCLUSION: Pretreatment with propofol is associated with attenuation of OALT-induced ALI, and the Nrf2 pathway is involved in the antioxidative processes.-
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/oximed/-
dc.relation.ispartofOxidative Medicine and Cellular Longevityen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titlePropofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation modelen_US
dc.typeArticleen_US
dc.identifier.emailYao, W: yaowf@hku.hken_US
dc.identifier.emailXia, Z: zyxia@hkucc.hku.hken_US
dc.identifier.authorityXia, Z=rp00532en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2014/258567-
dc.identifier.pmid24669282-
dc.identifier.pmcidPMC3941594-
dc.identifier.hkuros235559en_US
dc.identifier.volume2014en_US
dc.identifier.isiWOS:000331834800001-
dc.publisher.placeUnited States-

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