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Conference Paper: Adipocyte fatty acid-binding protein potentiates toxic lipids-induced endoplasmic reticulum stress via suppression of JAK2-dependent autophagy

TitleAdipocyte fatty acid-binding protein potentiates toxic lipids-induced endoplasmic reticulum stress via suppression of JAK2-dependent autophagy
Authors
KeywordsMedical sciences
Issue Date2014
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
Citation
The 19th Medical Research Conference (MRC 2014), Department of Medicine, The University of Hong Kong, 18 January 2014. In Hong Kong Medical Journal, 2014, v. 20 suppl. 1, p. 23, abstract 30 How to Cite?
AbstractINTRODUCTION: Chronic inflammation is the key link between obesity and its related metabolic complications. Endoplasmic reticulum (ER) stress is the potent trigger of inflammation in obese adipose tissue but how ER stress in immune cells relates to inflammation is unclear. Adipocyte fatty acid–binding protein (A-FABP) regulates endotoxin-induced inflammation in macrophages by forming a positive feedback loop with c-Jun-N terminal kinase (JNK) which is the downstream regulator of ER stress. Defective autophagy is shown in obese liver which leads to insulin resistance and elevated ER stress. Here we investigate the role of A-FABP in association with autophagy in potentiating toxic lipids-induced ER stress in macrophages …
DescriptionOral Presentation
Persistent Identifierhttp://hdl.handle.net/10722/202274
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorHoo, RLC-
dc.contributor.authorShu, L-
dc.contributor.authorLam, KSL-
dc.contributor.authorXu, A-
dc.date.accessioned2014-09-02T08:07:47Z-
dc.date.available2014-09-02T08:07:47Z-
dc.date.issued2014-
dc.identifier.citationThe 19th Medical Research Conference (MRC 2014), Department of Medicine, The University of Hong Kong, 18 January 2014. In Hong Kong Medical Journal, 2014, v. 20 suppl. 1, p. 23, abstract 30-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/202274-
dc.descriptionOral Presentation-
dc.description.abstractINTRODUCTION: Chronic inflammation is the key link between obesity and its related metabolic complications. Endoplasmic reticulum (ER) stress is the potent trigger of inflammation in obese adipose tissue but how ER stress in immune cells relates to inflammation is unclear. Adipocyte fatty acid–binding protein (A-FABP) regulates endotoxin-induced inflammation in macrophages by forming a positive feedback loop with c-Jun-N terminal kinase (JNK) which is the downstream regulator of ER stress. Defective autophagy is shown in obese liver which leads to insulin resistance and elevated ER stress. Here we investigate the role of A-FABP in association with autophagy in potentiating toxic lipids-induced ER stress in macrophages …-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectMedical sciences-
dc.titleAdipocyte fatty acid-binding protein potentiates toxic lipids-induced endoplasmic reticulum stress via suppression of JAK2-dependent autophagyen_US
dc.typeConference_Paperen_US
dc.identifier.emailHoo, RLC: rubyhoo@hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.emailXu, A: amxu@hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros237137-
dc.identifier.volume20-
dc.identifier.issuesuppl. 1-
dc.identifier.spage23, abstract 30-
dc.identifier.epage23, abstract 30-
dc.publisher.placeHong Kong-

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