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Article: Engineering supported membranes for cell biology

TitleEngineering supported membranes for cell biology
Authors
KeywordsLipid bilayer
Immunological synapse
Supported membranes
Spatial mutation
Membrane patterning techniques
Membrane curvature modulation
Issue Date2010
Citation
Medical and Biological Engineering and Computing, 2010, v. 48, n. 10, p. 955-963 How to Cite?
AbstractCell membranes exhibit multiple layers of complexity, ranging from their specific molecular content to their emergent mechanical properties and dynamic spatial organization. Both compositional and geometrical organizations of membrane components are known to play important roles in life processes, including signal transduction. Supported membranes, comprised of a bilayer assembly of phospholipids on the solid substrate, have been productively served as model systems to study wide range problems in cell biology. Because lateral mobility of membrane components is readily preserved, supported lipid membranes with signaling molecules can be utilized to effectively trigger various intercellular reactions. The spatial organization and mechanical deformation of supported membranes can also be manipulated by patterning underlying substrates with modern micro- and nano-fabrication techniques. This article focuses on various applications and methods to spatially patterned biomembranes by means of curvature modulations and spatial reorganizations, and utilizing them to interface with live cells. The integration of biological components into synthetic devices provides a unique approach to investigate molecular mechanisms in cell biology. © 2010 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/202143
ISSN
2015 Impact Factor: 1.797
2015 SCImago Journal Rankings: 0.798
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYu, Chenghan-
dc.contributor.authorGroves, Jay T.-
dc.date.accessioned2014-08-22T02:57:43Z-
dc.date.available2014-08-22T02:57:43Z-
dc.date.issued2010-
dc.identifier.citationMedical and Biological Engineering and Computing, 2010, v. 48, n. 10, p. 955-963-
dc.identifier.issn0140-0118-
dc.identifier.urihttp://hdl.handle.net/10722/202143-
dc.description.abstractCell membranes exhibit multiple layers of complexity, ranging from their specific molecular content to their emergent mechanical properties and dynamic spatial organization. Both compositional and geometrical organizations of membrane components are known to play important roles in life processes, including signal transduction. Supported membranes, comprised of a bilayer assembly of phospholipids on the solid substrate, have been productively served as model systems to study wide range problems in cell biology. Because lateral mobility of membrane components is readily preserved, supported lipid membranes with signaling molecules can be utilized to effectively trigger various intercellular reactions. The spatial organization and mechanical deformation of supported membranes can also be manipulated by patterning underlying substrates with modern micro- and nano-fabrication techniques. This article focuses on various applications and methods to spatially patterned biomembranes by means of curvature modulations and spatial reorganizations, and utilizing them to interface with live cells. The integration of biological components into synthetic devices provides a unique approach to investigate molecular mechanisms in cell biology. © 2010 The Author(s).-
dc.languageeng-
dc.relation.ispartofMedical and Biological Engineering and Computing-
dc.subjectLipid bilayer-
dc.subjectImmunological synapse-
dc.subjectSupported membranes-
dc.subjectSpatial mutation-
dc.subjectMembrane patterning techniques-
dc.subjectMembrane curvature modulation-
dc.titleEngineering supported membranes for cell biology-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11517-010-0634-x-
dc.identifier.pmid20559751-
dc.identifier.scopuseid_2-s2.0-77957767638-
dc.identifier.volume48-
dc.identifier.issue10-
dc.identifier.spage955-
dc.identifier.epage963-
dc.identifier.isiWOS:000282184600003-

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