File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: An investigation of the potential association between retinal detachment and oral fluoroquinolones: a self-controlled case series study

TitleAn investigation of the potential association between retinal detachment and oral fluoroquinolones: a self-controlled case series study
Authors
KeywordsAdverse drug reactions
Antimicrobials
Hong Kong
Pharmacoepidemiology
Taiwan
Issue Date2014
PublisherOxford University Press. The Journal's web site is located at http://jac.oxfordjournals.org/
Citation
Journal of Antimicrobial Chemotherapy, 2014, v. 69 n. 9, p. 2563-2567 How to Cite?
AbstractObjectives: A study reported a significant association between oral fluoroquinolones and the development of retinal detachment among current users of oral fluoroquinolones (Etminan M, Forooghian F, Brophy JM et al. JAMA 2012; 307: 1414–9). However, other published studies have discordant results. This study aimed to investigate this association and to estimate the absolute risk of developing retinal detachment in patients exposed to oral fluoroquinolones. Methods: A self-controlled case series study was conducted with data retrieved from the Hong Kong Clinical Data Analysis and Reporting System database and the Taiwan National Health Insurance Research Database. Hong Kong and Taiwanese patients who had prescriptions for oral fluoroquinolones and a procedure for retinal detachment between 2001 and 2012 and between 2000 and 2010, respectively, were defined as cases and included in the analysis. Results: A total of 9 events were found during the fluoroquinolone-exposed period and 1407 events were found during the non-exposed period. The adjusted incidence rate ratio in the combined model was 1.26 (0.65–2.47). The crude absolute risk of experiencing retinal detachment whilst on oral fluoroquinolones was ∼1.3 per 200 000 prescriptions. Conclusions: Our study does not support the association between the use of fluoroquinolones and the development of retinal detachment and our findings are strikingly similar to that of the study conducted in Denmark. Doubt is cast on the association between the use of fluoroquinolones and the development of retinal detachment. Therefore, the use of fluoroquinolones should not be precluded based on the current evidence on the risk of retinal detachment. The impact of different ethnicities on the response to fluoroquinolones should also be investigated.
Persistent Identifierhttp://hdl.handle.net/10722/202113
ISSN
2017 Impact Factor: 5.217
2015 SCImago Journal Rankings: 2.157
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChui, CSL-
dc.contributor.authorMan, KKC-
dc.contributor.authorCheng, CL-
dc.contributor.authorChan, EW-
dc.contributor.authorLau, WCY-
dc.contributor.authorCheng, VCC-
dc.contributor.authorWong, DSH-
dc.contributor.authorKao Yang, Y-
dc.contributor.authorWong, ICK-
dc.date.accessioned2014-08-21T08:04:23Z-
dc.date.available2014-08-21T08:04:23Z-
dc.date.issued2014-
dc.identifier.citationJournal of Antimicrobial Chemotherapy, 2014, v. 69 n. 9, p. 2563-2567-
dc.identifier.issn0305-7453-
dc.identifier.urihttp://hdl.handle.net/10722/202113-
dc.description.abstractObjectives: A study reported a significant association between oral fluoroquinolones and the development of retinal detachment among current users of oral fluoroquinolones (Etminan M, Forooghian F, Brophy JM et al. JAMA 2012; 307: 1414–9). However, other published studies have discordant results. This study aimed to investigate this association and to estimate the absolute risk of developing retinal detachment in patients exposed to oral fluoroquinolones. Methods: A self-controlled case series study was conducted with data retrieved from the Hong Kong Clinical Data Analysis and Reporting System database and the Taiwan National Health Insurance Research Database. Hong Kong and Taiwanese patients who had prescriptions for oral fluoroquinolones and a procedure for retinal detachment between 2001 and 2012 and between 2000 and 2010, respectively, were defined as cases and included in the analysis. Results: A total of 9 events were found during the fluoroquinolone-exposed period and 1407 events were found during the non-exposed period. The adjusted incidence rate ratio in the combined model was 1.26 (0.65–2.47). The crude absolute risk of experiencing retinal detachment whilst on oral fluoroquinolones was ∼1.3 per 200 000 prescriptions. Conclusions: Our study does not support the association between the use of fluoroquinolones and the development of retinal detachment and our findings are strikingly similar to that of the study conducted in Denmark. Doubt is cast on the association between the use of fluoroquinolones and the development of retinal detachment. Therefore, the use of fluoroquinolones should not be precluded based on the current evidence on the risk of retinal detachment. The impact of different ethnicities on the response to fluoroquinolones should also be investigated.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://jac.oxfordjournals.org/-
dc.relation.ispartofJournal of Antimicrobial Chemotherapy-
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Antimicrobial Chemotherapy following peer review. The definitive publisher-authenticated version is available online at: http://dx.doi.org/10.1093/jac/dku145.-
dc.subjectAdverse drug reactions-
dc.subjectAntimicrobials-
dc.subjectHong Kong-
dc.subjectPharmacoepidemiology-
dc.subjectTaiwan-
dc.titleAn investigation of the potential association between retinal detachment and oral fluoroquinolones: a self-controlled case series study-
dc.typeArticle-
dc.identifier.emailMan, KKC: mkckth@hku.hk-
dc.identifier.emailChan, EW: ewchan@hku.hk-
dc.identifier.emailCheng, VCC: vcccheng@hkucc.hku.hk-
dc.identifier.emailWong, DSH: shdwong@hku.hk-
dc.identifier.emailWong, ICK: wongick@hku.hk-
dc.identifier.authorityChan, EW=rp01587-
dc.identifier.authorityWong, DSH=rp00516-
dc.identifier.authorityWong, ICK=rp01480-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/jac/dku145-
dc.identifier.pmid24833754-
dc.identifier.scopuseid_2-s2.0-84905971414-
dc.identifier.hkuros233682-
dc.identifier.hkuros287775-
dc.identifier.volume69-
dc.identifier.issue9-
dc.identifier.spage2563-
dc.identifier.epage2567-
dc.identifier.isiWOS:000343322200036-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats