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Article: Expression of cytokines on the iris of patients with neovascular glaucoma

TitleExpression of cytokines on the iris of patients with neovascular glaucoma
Authors
Issue Date2015
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1755-375X&site=1
Citation
Acta Ophthalmologica, 2015, v. 93 n. 2, p. e100-e104 How to Cite?
AbstractPURPOSE: To determine the expression levels of cytokines, including growth factors, inflammatory cytokines, and cell migration associated factors on the iris from subjects with neovascular glaucoma (NVG). METHODS: After receiving formal consent from 12 subjects with NVG secondary to proliferative diabetic retinopathy and 12 subjects with primary open angle glaucoma (POAG), trabeculectomy was performed and iris specimens were collected during the surgery. Each subject with NVG received intravitreal injection of bevacizumab 1 week prior to the surgery. The mRNA level of vascular endothelial growth factor, basic fibroblastic growth factor, placental-induced growth factor, interleukin-2, interleukin 6, tumour necrosis factor alpha, intercellular adhesion molecule 1 (ICAM-1) and integrin subunit alphaV were determined by real-time polymerase chain reaction. The mRNA levels were compared between the two groups. RESULTS: The mRNA levels of all inflammatory cytokines and integrin subunit alphaV were significantly increased in the NVG group compared with POAG controls. However, the mRNA level of growth factors and ICAM-1 did not show any difference between the two groups. CONCLUSIONS: Inflammatory process maybe an important cause of iris neovascularization in subjects with NVG in addition to growth factors alone. Further studies should focus on the effect of growth factors in different phases in the pathogenesis of NVG.
Persistent Identifierhttp://hdl.handle.net/10722/202111
ISSN
2015 Impact Factor: 3.032
2015 SCImago Journal Rankings: 1.473

 

DC FieldValueLanguage
dc.contributor.authorHou, XRen_US
dc.contributor.authorMiao, Hen_US
dc.contributor.authorTao, Yen_US
dc.contributor.authorLi, XXen_US
dc.contributor.authorWong, YHIen_US
dc.date.accessioned2014-08-21T08:04:23Z-
dc.date.available2014-08-21T08:04:23Z-
dc.date.issued2015en_US
dc.identifier.citationActa Ophthalmologica, 2015, v. 93 n. 2, p. e100-e104en_US
dc.identifier.issn1755-375Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/202111-
dc.description.abstractPURPOSE: To determine the expression levels of cytokines, including growth factors, inflammatory cytokines, and cell migration associated factors on the iris from subjects with neovascular glaucoma (NVG). METHODS: After receiving formal consent from 12 subjects with NVG secondary to proliferative diabetic retinopathy and 12 subjects with primary open angle glaucoma (POAG), trabeculectomy was performed and iris specimens were collected during the surgery. Each subject with NVG received intravitreal injection of bevacizumab 1 week prior to the surgery. The mRNA level of vascular endothelial growth factor, basic fibroblastic growth factor, placental-induced growth factor, interleukin-2, interleukin 6, tumour necrosis factor alpha, intercellular adhesion molecule 1 (ICAM-1) and integrin subunit alphaV were determined by real-time polymerase chain reaction. The mRNA levels were compared between the two groups. RESULTS: The mRNA levels of all inflammatory cytokines and integrin subunit alphaV were significantly increased in the NVG group compared with POAG controls. However, the mRNA level of growth factors and ICAM-1 did not show any difference between the two groups. CONCLUSIONS: Inflammatory process maybe an important cause of iris neovascularization in subjects with NVG in addition to growth factors alone. Further studies should focus on the effect of growth factors in different phases in the pathogenesis of NVG.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1755-375X&site=1en_US
dc.relation.ispartofActa Ophthalmologicaen_US
dc.rightsThe definitive version is available at www3.interscience.wiley.comen_US
dc.titleExpression of cytokines on the iris of patients with neovascular glaucomaen_US
dc.typeArticleen_US
dc.identifier.emailWong, YHI: wongyhi@hku.hken_US
dc.identifier.authorityWong, YHI=rp01467en_US
dc.identifier.doi10.1111/aos.12510en_US
dc.identifier.hkuros233181en_US
dc.publisher.placeUnited Statesen_US

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