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Article: Aldehyde dehydrogenase 2-a potential genetic risk factor for lung function among southern Chinese: Evidence from the Guangzhou Biobank Cohort Study

TitleAldehyde dehydrogenase 2-a potential genetic risk factor for lung function among southern Chinese: Evidence from the Guangzhou Biobank Cohort Study
Authors
KeywordsAldehyde dehydrogenase 2
Southern Chinese
Lung function
Issue Date2014
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/annepidem
Citation
Annals of Epidemiology, 2014, v. 24 n. 8, p. 606-611 How to Cite?
AbstractPurpose: In Asia, moderate alcohol users have better lung function. Never users have more inactive aldehyde dehydrogenase 2 (ALDH2) alleles (A) potentially generating confounding because inactive alleles may increase acetaldehyde exposure and reduce lung function. Methods: We examined the association of ALDH2 genotypes with percentage predicted lung function (forced expiratory volume in 1second; forced vital capacity) for age, sex, and height among 5641 older Chinese using multivariable linear regression. Results: ALDH2 genotypes were associated with alcohol use and height but not other attributes. Inactive alleles were inversely associated with lung function (percentage predicted forced expiratory volume in 1second-1.52%, 95% confidence interval [CI],-2.52% to-0.51% for one inactive allele and-2.05%, 95% CI,-3.85% to-0.26% for two inactive alleles compared with two active alleles; and for percentage predicted forced vital capacity-1.25%, 95% CI-2.15% to-0.35% and-1.65%, 95% CI,-3.25% to-0.04%). The association of moderate use with lung function was attenuated after adjusting for ALDH2, in addition to other potential confounders. Conclusions: Previous findings in Chinese may be confounded by ALDH2. High frequency of inactive ALDH2 alleles in East Asia may exacerbate the effect of environmental acetaldehyde exposure on lung function and potentially on chronic obstructive pulmonary disease. © 2014 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/202044
ISSN
2015 Impact Factor: 2.335
2015 SCImago Journal Rankings: 1.439
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAu Yeung, SLRen_US
dc.contributor.authorJiang, Cen_US
dc.contributor.authorCheng, KKen_US
dc.contributor.authorAdab, Pen_US
dc.contributor.authorLam, HKBen_US
dc.contributor.authorLiu, Ben_US
dc.contributor.authorZhang, Wen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorLeung, GMen_US
dc.contributor.authorSchooling, CMen_US
dc.date.accessioned2014-08-21T07:59:36Z-
dc.date.available2014-08-21T07:59:36Z-
dc.date.issued2014en_US
dc.identifier.citationAnnals of Epidemiology, 2014, v. 24 n. 8, p. 606-611en_US
dc.identifier.issn1047-2797-
dc.identifier.urihttp://hdl.handle.net/10722/202044-
dc.description.abstractPurpose: In Asia, moderate alcohol users have better lung function. Never users have more inactive aldehyde dehydrogenase 2 (ALDH2) alleles (A) potentially generating confounding because inactive alleles may increase acetaldehyde exposure and reduce lung function. Methods: We examined the association of ALDH2 genotypes with percentage predicted lung function (forced expiratory volume in 1second; forced vital capacity) for age, sex, and height among 5641 older Chinese using multivariable linear regression. Results: ALDH2 genotypes were associated with alcohol use and height but not other attributes. Inactive alleles were inversely associated with lung function (percentage predicted forced expiratory volume in 1second-1.52%, 95% confidence interval [CI],-2.52% to-0.51% for one inactive allele and-2.05%, 95% CI,-3.85% to-0.26% for two inactive alleles compared with two active alleles; and for percentage predicted forced vital capacity-1.25%, 95% CI-2.15% to-0.35% and-1.65%, 95% CI,-3.25% to-0.04%). The association of moderate use with lung function was attenuated after adjusting for ALDH2, in addition to other potential confounders. Conclusions: Previous findings in Chinese may be confounded by ALDH2. High frequency of inactive ALDH2 alleles in East Asia may exacerbate the effect of environmental acetaldehyde exposure on lung function and potentially on chronic obstructive pulmonary disease. © 2014 Elsevier Inc.-
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/annepidem-
dc.relation.ispartofAnnals of Epidemiologyen_US
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Annals of Epidemiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Annals of Epidemiology, 2014, v. 24 n. 8, p. 606-611. DOI: 10.1016/j.annepidem.2014.05.015-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAldehyde dehydrogenase 2-
dc.subjectSouthern Chinese-
dc.subjectLung function-
dc.titleAldehyde dehydrogenase 2-a potential genetic risk factor for lung function among southern Chinese: Evidence from the Guangzhou Biobank Cohort Studyen_US
dc.typeArticleen_US
dc.identifier.emailAu Yeung, SLR: ayslryan@hku.hken_US
dc.identifier.emailJiang, C: cqjiang@hkucc.hku.hken_US
dc.identifier.emailCheng, KK: chengkk@hkucc.hku.hken_US
dc.identifier.emailAdab, P: padab@hkucc.hku.hken_US
dc.identifier.emailLam, HKB: lamhkb@hkucc.hku.hken_US
dc.identifier.emailZhang, W: zhangws9@hku.hken_US
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_US
dc.identifier.emailLeung, GM: gmleung@hku.hken_US
dc.identifier.emailSchooling, CM: cms1@hkucc.hku.hken_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.identifier.authorityLeung, GM=rp00460en_US
dc.identifier.authoritySchooling, CM=rp00504en_US
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.annepidem.2014.05.015en_US
dc.identifier.pmid25084704-
dc.identifier.scopuseid_2-s2.0-84905009853-
dc.identifier.hkuros233975en_US
dc.identifier.volume24en_US
dc.identifier.issue8en_US
dc.identifier.spage606en_US
dc.identifier.epage611en_US
dc.identifier.isiWOS:000340214800008-
dc.publisher.placeUnited States-

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