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Article: Expansion of genotypic diversity and establishment of 2009 H1N1 pandemic-origin internal genes in pigs in China

TitleExpansion of genotypic diversity and establishment of 2009 H1N1 pandemic-origin internal genes in pigs in China
Authors
Issue Date2014
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal of Virology, 2014, v. 88 n. 18, p. 10864-10874 How to Cite?
AbstractTwo-way transmission of influenza viruses between humans and swine has been frequently observed, and the occurrence of the 2009 H1N1 pandemic influenza virus (pdm/09) demonstrated that swine-origin viruses could facilitate the genesis of a pandemic strain. Although multiple introductions to and reassortment in swine of the pdm/09 virus have been repeatedly reported in both Eurasia and the Americas, its long-term impact on the development of swine influenza viruses (SIVs) has not been systematically explored. Our comprehensive evolutionary studies of the complete genomes of 387 SIVs obtained from 2009 to 2012 by influenza virus surveillance in China revealed 17 reassortant genotypes with pdm/09-origin genes. Even though the entire 2009 pandemic virus and its surface genes cannot persist, its internal genes have become established and are now the predominant lineages in pigs in the region. The main persistent pdm/09-origin reassortant forms had at least five pdm/09-origin internal genes, and their surface genes were primarily of European avian-like (EA) or human H3N2-like SIV origin. These findings represent a marked change in the evolutionary patterns and ecosystem of SIVs in China. It is possible that the pdm/09-origin internal genes are in the process of replacing EA or triple-reassortant-like internal genes. These alterations in the SIV gene pool need to be continually monitored to assess changes in the potential for SIV transmission to humans. IMPORTANCE Shortly after the emergence of the 2009 pandemic H1N1 (pdm/09) influenza virus, it was transmitted from humans to pigs and this continues to occur around the world. Many reassortants between pdm/09-origin viruses and enzootic swine influenza viruses (SIVs) have been detected. However, the long-term impact of pdm/09-origin viruses on the SIV gene pool, which could lead to the generation of influenza viruses with the potential to infect humans, has not been systematically examined. From extensive surveillance of SIVs over a 38-month period in southern China, it was found that although neither complete pdm/09 viruses nor their surface genes could persist in pigs, their internal genes did persist. Over the survey period, these internal genes became predominant, potentially replacing those of the enzootic SIV lineages. The altered diversity of the SIV gene pool needs to be closely monitored for changes in the potential for SIV transmission to humans.
Persistent Identifierhttp://hdl.handle.net/10722/202035
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
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DC FieldValueLanguage
dc.contributor.authorLiang, Hen_US
dc.contributor.authorLam, TTYen_US
dc.contributor.authorFan, Xen_US
dc.contributor.authorChen, Xen_US
dc.contributor.authorZeng, Yen_US
dc.contributor.authorZhou, Jen_US
dc.contributor.authorDuan, Len_US
dc.contributor.authorTse, MTen_US
dc.contributor.authorChan, CHen_US
dc.contributor.authorLi, Len_US
dc.contributor.authorLeung, TYen_US
dc.contributor.authorYip, CHen_US
dc.contributor.authorCheung, CLen_US
dc.contributor.authorZhou, Ben_US
dc.contributor.authorSmith, DKen_US
dc.contributor.authorPoon, LLMen_US
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorGuan, Yen_US
dc.contributor.authorZhu, Hen_US
dc.date.accessioned2014-08-21T07:59:30Z-
dc.date.available2014-08-21T07:59:30Z-
dc.date.issued2014-
dc.identifier.citationJournal of Virology, 2014, v. 88 n. 18, p. 10864-10874en_US
dc.identifier.issn0022-538X-
dc.identifier.urihttp://hdl.handle.net/10722/202035-
dc.description.abstractTwo-way transmission of influenza viruses between humans and swine has been frequently observed, and the occurrence of the 2009 H1N1 pandemic influenza virus (pdm/09) demonstrated that swine-origin viruses could facilitate the genesis of a pandemic strain. Although multiple introductions to and reassortment in swine of the pdm/09 virus have been repeatedly reported in both Eurasia and the Americas, its long-term impact on the development of swine influenza viruses (SIVs) has not been systematically explored. Our comprehensive evolutionary studies of the complete genomes of 387 SIVs obtained from 2009 to 2012 by influenza virus surveillance in China revealed 17 reassortant genotypes with pdm/09-origin genes. Even though the entire 2009 pandemic virus and its surface genes cannot persist, its internal genes have become established and are now the predominant lineages in pigs in the region. The main persistent pdm/09-origin reassortant forms had at least five pdm/09-origin internal genes, and their surface genes were primarily of European avian-like (EA) or human H3N2-like SIV origin. These findings represent a marked change in the evolutionary patterns and ecosystem of SIVs in China. It is possible that the pdm/09-origin internal genes are in the process of replacing EA or triple-reassortant-like internal genes. These alterations in the SIV gene pool need to be continually monitored to assess changes in the potential for SIV transmission to humans. IMPORTANCE Shortly after the emergence of the 2009 pandemic H1N1 (pdm/09) influenza virus, it was transmitted from humans to pigs and this continues to occur around the world. Many reassortants between pdm/09-origin viruses and enzootic swine influenza viruses (SIVs) have been detected. However, the long-term impact of pdm/09-origin viruses on the SIV gene pool, which could lead to the generation of influenza viruses with the potential to infect humans, has not been systematically examined. From extensive surveillance of SIVs over a 38-month period in southern China, it was found that although neither complete pdm/09 viruses nor their surface genes could persist in pigs, their internal genes did persist. Over the survey period, these internal genes became predominant, potentially replacing those of the enzootic SIV lineages. The altered diversity of the SIV gene pool needs to be closely monitored for changes in the potential for SIV transmission to humans.-
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/-
dc.relation.ispartofJournal of Virologyen_US
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.-
dc.titleExpansion of genotypic diversity and establishment of 2009 H1N1 pandemic-origin internal genes in pigs in Chinaen_US
dc.typeArticleen_US
dc.identifier.emailLam, TTY: ttylam@hku.hken_US
dc.identifier.emailDuan, L: lianduan@hku.hken_US
dc.identifier.emailTse, MT: tsemay@hku.hken_US
dc.identifier.emailChan, CH: chchan86@hku.hken_US
dc.identifier.emailLi, L: lifeng@hkucc.hku.hken_US
dc.identifier.emailLeung, TY: lkitty@hku.hken_US
dc.identifier.emailYip, CH: yiperic@hku.hken_US
dc.identifier.emailCheung, CL: cheungcl@hkucc.hku.hken_US
dc.identifier.emailSmith, DK: dsmith@hku.hken_US
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_US
dc.identifier.emailZhu, H: zhuhch@hku.hken_US
dc.identifier.authorityLam, TTY=rp01733en_US
dc.identifier.authorityPoon, LLM=rp00484en_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.identifier.authorityGuan, Y=rp00397en_US
dc.identifier.authorityZhu, H=rp01535en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1128/JVI.01327-14en_US
dc.identifier.pmid25008935-
dc.identifier.pmcidPMC4178866-
dc.identifier.hkuros232586en_US
dc.identifier.volume88-
dc.identifier.issue18-
dc.identifier.spage10864-
dc.identifier.epage10874-
dc.identifier.isiWOS:000341234900052-
dc.publisher.placeUnited States-
dc.relation.projectEvolution and Risk assessment studies for 2009 pandemic-like reassortant swine influenza viruses from China-
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-

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