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Conference Paper: Early Zebrafish Development, a Screening Model to Identify Effects of Endocrine Disrupting Chemicals

TitleEarly Zebrafish Development, a Screening Model to Identify Effects of Endocrine Disrupting Chemicals
Authors
Issue Date2014
PublisherThe Japanese Society of Developmental Biologists (JSDB).
Citation
The 47th Annual Meeting forf the Japanese Society of Developmental Biologists (JSDB), Nagoya, Japan, 27-30 May 2014, p. abstract no. P-184B How to Cite?
AbstractThe exposure of mammalian foetus to endocrine disrupting chemicals (EDCs) has been hypothesized to increase the propensity of offspring to develop organ dysfunction or diseases in adult life. Since fetal development is recognized as the most susceptible stage to be affected by different kinds of stress, there is a pressing need to understand the effects of EDCs on this critical developmental window. However, the understanding of the mechanistic basis of this cause-effect relationship is in fact stunningly complex, largely hampered by the complexity of the mammalian developmental processes. Zebrafish, an excellent model widely used in the field of developmental biology, provides an invaluable tool to the field of developmental toxicology. Furthermore, zebrafish was used in classical toxicological studies in sublethal or lethal toxicity test by exposure to different types of chemical contaminants. However, these studies did not provide information on the mechanistic action of the contaminants at realistic exposure dosages. In this study, the approach of using standard whole-mount in situ hybridization screening method was adopted to determine early developmental defects in zebrafish embryos exposed to the ubiquitous contaminant, bisphenol A (BPA) at three critical early developmental stages (60–75% epiboly, 8–10 somite, and prim-5). This screening strategy provided an important evidence to illustrate the effects of BPA on dorsal-ventral (DV) patterning, segmentation, and brain development in zebrafish embryos within 24 hours of the exposure.
DescriptionPoster Session
Persistent Identifierhttp://hdl.handle.net/10722/201718

 

DC FieldValueLanguage
dc.contributor.authorLai, KPen_US
dc.contributor.authorWu, SSen_US
dc.contributor.authorYeung, BHY-
dc.contributor.authorWan, HT-
dc.contributor.authorTse, WKF-
dc.contributor.authorWong, CKC-
dc.date.accessioned2014-08-21T07:38:20Z-
dc.date.available2014-08-21T07:38:20Z-
dc.date.issued2014en_US
dc.identifier.citationThe 47th Annual Meeting forf the Japanese Society of Developmental Biologists (JSDB), Nagoya, Japan, 27-30 May 2014, p. abstract no. P-184Ben_US
dc.identifier.urihttp://hdl.handle.net/10722/201718-
dc.descriptionPoster Session-
dc.description.abstractThe exposure of mammalian foetus to endocrine disrupting chemicals (EDCs) has been hypothesized to increase the propensity of offspring to develop organ dysfunction or diseases in adult life. Since fetal development is recognized as the most susceptible stage to be affected by different kinds of stress, there is a pressing need to understand the effects of EDCs on this critical developmental window. However, the understanding of the mechanistic basis of this cause-effect relationship is in fact stunningly complex, largely hampered by the complexity of the mammalian developmental processes. Zebrafish, an excellent model widely used in the field of developmental biology, provides an invaluable tool to the field of developmental toxicology. Furthermore, zebrafish was used in classical toxicological studies in sublethal or lethal toxicity test by exposure to different types of chemical contaminants. However, these studies did not provide information on the mechanistic action of the contaminants at realistic exposure dosages. In this study, the approach of using standard whole-mount in situ hybridization screening method was adopted to determine early developmental defects in zebrafish embryos exposed to the ubiquitous contaminant, bisphenol A (BPA) at three critical early developmental stages (60–75% epiboly, 8–10 somite, and prim-5). This screening strategy provided an important evidence to illustrate the effects of BPA on dorsal-ventral (DV) patterning, segmentation, and brain development in zebrafish embryos within 24 hours of the exposure.en_US
dc.languageengen_US
dc.publisherThe Japanese Society of Developmental Biologists (JSDB).-
dc.relation.ispartofAnnual Meeting forf the Japanese Society of Developmental Biologists (JSDB)en_US
dc.titleEarly Zebrafish Development, a Screening Model to Identify Effects of Endocrine Disrupting Chemicalsen_US
dc.typeConference_Paperen_US
dc.identifier.emailLai, KP: balllai@hku.hken_US
dc.identifier.emailWu, SS: rudolfwu@hku.hken_US
dc.identifier.authorityLai, KP=rp01753en_US
dc.identifier.authorityWu, SS=rp01398en_US
dc.identifier.hkuros233293en_US
dc.publisher.placeJapan-

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