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Conference Paper: Nitric oxide/Caveolin-1/MMP pathway: a novel therapeutic strategy for drug discovery from herbal medicine targeting blood-brain-barrier disruption during cerebral Ischemia-reperfusion injury

TitleNitric oxide/Caveolin-1/MMP pathway: a novel therapeutic strategy for drug discovery from herbal medicine targeting blood-brain-barrier disruption during cerebral Ischemia-reperfusion injury
Authors
Issue Date2013
PublisherInternational Joint Conference of ICM-PCMCAIM
Citation
The 2013 Joint Congress for International Conference for Microcirculation and the 13th Annual Conference of the Professional Committee for Microcirculation, Chinese Association of Integrative Medicine (ICM-PCMCAIM), Beijing, China, 6-8 September 2013. How to Cite?
微循环国际研讨会暨第十三届全国中西医结合微循环学术会议, 中国, 北京, 2013年9月 6‐8日. How to Cite?
AbstractAIMS: Blood-brain-barrier (BBB) disruption is a crucial process in stroke, but no effective drug is available. Thus, drug discovery targeting BBB permeability becomes timely important. In this study, we hypothesized that Nitric oxide (NO)/Cav-1/Matrix metalloproteinase (MMP) pathway is important therapeutic targets in preventing BBB disruption. Following, we investigated the effects of CG, an active compound isolated from Astragali Radix on regulating this pathway and protecting BBB permeability and brain damage during cerebral ischemia-reperfusion injury. METHODS: SD rats were subject to ...
DescriptionSymposium 1 - Permeability: no. S1-2
Persistent Identifierhttp://hdl.handle.net/10722/201703

 

DC FieldValueLanguage
dc.contributor.authorShen, Jen_US
dc.contributor.authorGu, Y-
dc.contributor.authorLiu, KJ-
dc.date.accessioned2014-08-21T07:37:37Z-
dc.date.available2014-08-21T07:37:37Z-
dc.date.issued2013en_US
dc.identifier.citationThe 2013 Joint Congress for International Conference for Microcirculation and the 13th Annual Conference of the Professional Committee for Microcirculation, Chinese Association of Integrative Medicine (ICM-PCMCAIM), Beijing, China, 6-8 September 2013.en_US
dc.identifier.citation微循环国际研讨会暨第十三届全国中西医结合微循环学术会议, 中国, 北京, 2013年9月 6‐8日.-
dc.identifier.urihttp://hdl.handle.net/10722/201703-
dc.descriptionSymposium 1 - Permeability: no. S1-2-
dc.description.abstractAIMS: Blood-brain-barrier (BBB) disruption is a crucial process in stroke, but no effective drug is available. Thus, drug discovery targeting BBB permeability becomes timely important. In this study, we hypothesized that Nitric oxide (NO)/Cav-1/Matrix metalloproteinase (MMP) pathway is important therapeutic targets in preventing BBB disruption. Following, we investigated the effects of CG, an active compound isolated from Astragali Radix on regulating this pathway and protecting BBB permeability and brain damage during cerebral ischemia-reperfusion injury. METHODS: SD rats were subject to ...-
dc.languageengen_US
dc.publisherInternational Joint Conference of ICM-PCMCAIM-
dc.relation.ispartofInternational Joint Conference of ICM-PCMCAIMen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleNitric oxide/Caveolin-1/MMP pathway: a novel therapeutic strategy for drug discovery from herbal medicine targeting blood-brain-barrier disruption during cerebral Ischemia-reperfusion injuryen_US
dc.typeConference_Paperen_US
dc.identifier.emailShen, J: shenjg@hku.hken_US
dc.identifier.authorityShen, J=rp00487en_US
dc.description.naturepostprint-
dc.identifier.hkuros233605en_US
dc.publisher.placeBeijing, China-

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