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Article: Aflatoxicosis Chemoprevention By Probiotic Lactobacillius And Lack Of Effect On The Major Histocompatibility Complex.

TitleAflatoxicosis Chemoprevention By Probiotic Lactobacillius And Lack Of Effect On The Major Histocompatibility Complex.
Authors
Issue Date2014
PublisherElsevier Ltd.
Citation
Res Vet Sci, 2014, v. 14, p. 170-172 How to Cite?
AbstractTurkeys are extremely sensitive to aflatoxin B1 (AFB1) which causes decreased growth, immunosuppression and liver necrosis. The purpose of this study was to determine whether probiotic Lactobacillus, shown to be protective in animal and clinical studies, would likewise confer protection in turkeys, which were treated for 11 days with either AFB1 (AFB; 1 ppm in diet), probiotic (PB; 1 × 1011 CFU/ml; oral, daily), probiotic + AFB1 (PBAFB), or PBS control (CNTL). The AFB1 induced drop in body and liver weights were restored to normal in CNTL and PBAFB groups. Hepatotoxicity markers were not significantly reduced by probiotic treatment. Major histocompatibility complex (MHC) genes BG1 and BG4, which are differentially expressed in liver and spleens, were not significantly affected by treatments. These data indicate modest protection, but the relatively high dietary AFB1 treatment, and the extreme sensitivity of this species may reveal limits of probiotic-based protection strategies.
Persistent Identifierhttp://hdl.handle.net/10722/201543

 

DC FieldValueLanguage
dc.contributor.authorRawal, Sen_US
dc.contributor.authorBauer, MMen_US
dc.contributor.authorMendoza, KMen_US
dc.contributor.authorEl-Nezamy, HSen_US
dc.contributor.authorHall, JRen_US
dc.contributor.authorKim, JEen_US
dc.contributor.authorStevens, JRen_US
dc.contributor.authorReed, KMen_US
dc.contributor.authorCoulombe, RAen_US
dc.date.accessioned2014-08-21T07:30:23Z-
dc.date.available2014-08-21T07:30:23Z-
dc.date.issued2014en_US
dc.identifier.citationRes Vet Sci, 2014, v. 14, p. 170-172en_US
dc.identifier.urihttp://hdl.handle.net/10722/201543-
dc.description.abstractTurkeys are extremely sensitive to aflatoxin B1 (AFB1) which causes decreased growth, immunosuppression and liver necrosis. The purpose of this study was to determine whether probiotic Lactobacillus, shown to be protective in animal and clinical studies, would likewise confer protection in turkeys, which were treated for 11 days with either AFB1 (AFB; 1 ppm in diet), probiotic (PB; 1 × 1011 CFU/ml; oral, daily), probiotic + AFB1 (PBAFB), or PBS control (CNTL). The AFB1 induced drop in body and liver weights were restored to normal in CNTL and PBAFB groups. Hepatotoxicity markers were not significantly reduced by probiotic treatment. Major histocompatibility complex (MHC) genes BG1 and BG4, which are differentially expressed in liver and spleens, were not significantly affected by treatments. These data indicate modest protection, but the relatively high dietary AFB1 treatment, and the extreme sensitivity of this species may reveal limits of probiotic-based protection strategies.en_US
dc.languageengen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofRes Vet Scien_US
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in <Journal title>. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#, ISSUE#, (DATE)] DOI#en_US
dc.titleAflatoxicosis Chemoprevention By Probiotic Lactobacillius And Lack Of Effect On The Major Histocompatibility Complex.en_US
dc.typeArticleen_US
dc.identifier.emailEl-Nezamy, HS: elnezami@hkucc.hku.hken_US
dc.identifier.authorityEl-Nezamy, HS=rp00694en_US
dc.identifier.doi10.1016/j.rvsc.2014.06.008en_US
dc.identifier.hkuros232319en_US
dc.identifier.volume14en_US
dc.identifier.spage170en_US
dc.identifier.epage172en_US

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