File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Genetic and Environmental Influences on Brain Function In Schizophrenia. An FMRI Study of the Maudsley Twin and Family Cohorts

TitleGenetic and Environmental Influences on Brain Function In Schizophrenia. An FMRI Study of the Maudsley Twin and Family Cohorts
Authors
Issue Date2014
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 4th Biennial Schizophrenia International Research Conference, Florence, Italy, 5–9 April 2014. In Schizophrenia Research, 2014, v. 153 suppl.1, p. S52, abstract no. 5:15 PM How to Cite?
AbstractBACKGROUND: Schizophrenia is a heritable but aetiologically complex disorder. Intermediate phenotypes as quantitative traits pathophysiologically closer to the underlying genetic risks represent an experimental strategy to help address this complexity. Verbal fluency performance satisfies many criteria for an intermediate phenotype for schizophrenia. Our aim was to assess the influence of genetic and environmental factors on this executive function task in schizophrenia. METHODS: We used a twin-sibling study of 206 subjects; 163 twins, varying in their zygosity and concordance for schizophrenia, and 43 singletons from siblings varying in their concordance for schizophrenia. We assessed performance and regional brain activation using functional magnetic resonance imaging, during a phonological verbal fluency task. After between group testing, we conducted full genetic modelling. RESULTS: Across groups there was a differential pattern of activation in fronto-temporal areas. Patients and their unaffected relatives developed greater activation in the left inferior frontal gyrus, and greater deactivation in the left hippocampal and middle temporal gyri bilaterally. These features were maximally evident in subjects with schizophrenia, and least in controls. When the analysis was restricted to the unaffected relatives and healthy controls, a similar pattern was evident, with the unaffected relatives showing greater inferior frontal and left superior temporal activation, and greater right parahippocampal and right superior/middle temporal deactivation than healthy controls. Genetic modelling indicated a phenotypic correlation between schizophrenia and increased activity in the inferior frontal gyrus and reduced activity in the left middle temporal gyrus and left hippocampus, which was principally due to shared genetic effects. DISCUSSION: Both schizophrenia and its familial vulnerability were associated altered frontal, parahippocampal and temporal activation during verbal fluency. The altered left inferior frontal activity was particularly associated with schizophrenia, while altered right middle/superior temporal and right medial temporal activity were more heritable and more intimately linked to the genetic risk for schizophrenia.
DescriptionConference theme: Fostering Collaboration in Schizophrenia Research
Oral presentation: Advances in Imaging in Schizophrenia I
This journal suppl. entitled: Abstracts of the 4th Biennial Schizophrenia International Research Conference
Persistent Identifierhttp://hdl.handle.net/10722/201422
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorPicchioni, MMen_US
dc.contributor.authorToulopoulou, T-
dc.contributor.authorRijsdijk, F-
dc.contributor.authorEttinger, U-
dc.contributor.authorPauli, A-
dc.contributor.authorValli, I-
dc.contributor.authorHall, MH-
dc.contributor.authorWalshe, M-
dc.contributor.authorMcDonald, C-
dc.contributor.authorMurray, RM-
dc.contributor.authorMcGuire, P-
dc.date.accessioned2014-08-21T07:27:01Z-
dc.date.available2014-08-21T07:27:01Z-
dc.date.issued2014en_US
dc.identifier.citationThe 4th Biennial Schizophrenia International Research Conference, Florence, Italy, 5–9 April 2014. In Schizophrenia Research, 2014, v. 153 suppl.1, p. S52, abstract no. 5:15 PMen_US
dc.identifier.issn0920-9964-
dc.identifier.urihttp://hdl.handle.net/10722/201422-
dc.descriptionConference theme: Fostering Collaboration in Schizophrenia Research-
dc.descriptionOral presentation: Advances in Imaging in Schizophrenia I-
dc.descriptionThis journal suppl. entitled: Abstracts of the 4th Biennial Schizophrenia International Research Conference-
dc.description.abstractBACKGROUND: Schizophrenia is a heritable but aetiologically complex disorder. Intermediate phenotypes as quantitative traits pathophysiologically closer to the underlying genetic risks represent an experimental strategy to help address this complexity. Verbal fluency performance satisfies many criteria for an intermediate phenotype for schizophrenia. Our aim was to assess the influence of genetic and environmental factors on this executive function task in schizophrenia. METHODS: We used a twin-sibling study of 206 subjects; 163 twins, varying in their zygosity and concordance for schizophrenia, and 43 singletons from siblings varying in their concordance for schizophrenia. We assessed performance and regional brain activation using functional magnetic resonance imaging, during a phonological verbal fluency task. After between group testing, we conducted full genetic modelling. RESULTS: Across groups there was a differential pattern of activation in fronto-temporal areas. Patients and their unaffected relatives developed greater activation in the left inferior frontal gyrus, and greater deactivation in the left hippocampal and middle temporal gyri bilaterally. These features were maximally evident in subjects with schizophrenia, and least in controls. When the analysis was restricted to the unaffected relatives and healthy controls, a similar pattern was evident, with the unaffected relatives showing greater inferior frontal and left superior temporal activation, and greater right parahippocampal and right superior/middle temporal deactivation than healthy controls. Genetic modelling indicated a phenotypic correlation between schizophrenia and increased activity in the inferior frontal gyrus and reduced activity in the left middle temporal gyrus and left hippocampus, which was principally due to shared genetic effects. DISCUSSION: Both schizophrenia and its familial vulnerability were associated altered frontal, parahippocampal and temporal activation during verbal fluency. The altered left inferior frontal activity was particularly associated with schizophrenia, while altered right middle/superior temporal and right medial temporal activity were more heritable and more intimately linked to the genetic risk for schizophrenia.-
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres-
dc.relation.ispartofSchizophrenia Researchen_US
dc.titleGenetic and Environmental Influences on Brain Function In Schizophrenia. An FMRI Study of the Maudsley Twin and Family Cohortsen_US
dc.typeConference_Paperen_US
dc.identifier.emailToulopoulou, T: timothea@hku.hken_US
dc.identifier.authorityToulopoulou, T=rp01542en_US
dc.identifier.doi10.1016/S0920-9964(14)70170-7-
dc.identifier.hkuros233860en_US
dc.identifier.volume153-
dc.identifier.issuesuppl.1-
dc.identifier.spageS52, abstract no. 5:15 PM-
dc.identifier.epageS52, abstract no. 5:15 PM-
dc.publisher.placeNetherlands-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats