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Conference Paper: CDK5-mediated hyperphosphorylation contributes to the lossof-SIRT1 function during the development of endothelial senescence
| Title | CDK5-mediated hyperphosphorylation contributes to the lossof-SIRT1 function during the development of endothelial senescence |
|---|---|
| Authors | |
| Issue Date | 2013 |
| Citation | The 2013 Annual Scientific Meeting of the International Academy of Cardiology and the 18th World Congress on Heart Disease, Vancouver, BC., Canada, 26-29 July 2013. How to Cite? |
| Abstract | BACKGROUND: During vascular aging, endothelial cells lying on the inner surface of the blood vessels present a senescent phonotype, triggering and accelerating atherosclerosis development. The anti-aging activity of SIRT1, a NAD-dependent deacetylase, is lost the during the occurrence of endothelial senescence (Cir Res 2010;106:1384-93). The present study aims to investigate the molecular mechanisms underlying the loss-of-SIRT1 function in senescent endothelial cells ... |
| Description | Session S29 - Molecular and Cellular Cardiology / Vascular Biology, Basic Research: abstract no. 250 |
| Persistent Identifier | http://hdl.handle.net/10722/201277 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Bai, B | en_US |
| dc.contributor.author | Liang, Y | en_US |
| dc.contributor.author | Xu, C | en_US |
| dc.contributor.author | Lee, MYK | en_US |
| dc.contributor.author | Xu, A | en_US |
| dc.contributor.author | Wu, DH | en_US |
| dc.contributor.author | Vanhoutte, PM | en_US |
| dc.contributor.author | Wang, Y | en_US |
| dc.date.accessioned | 2014-08-21T07:20:17Z | - |
| dc.date.available | 2014-08-21T07:20:17Z | - |
| dc.date.issued | 2013 | en_US |
| dc.identifier.citation | The 2013 Annual Scientific Meeting of the International Academy of Cardiology and the 18th World Congress on Heart Disease, Vancouver, BC., Canada, 26-29 July 2013. | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/201277 | - |
| dc.description | Session S29 - Molecular and Cellular Cardiology / Vascular Biology, Basic Research: abstract no. 250 | - |
| dc.description.abstract | BACKGROUND: During vascular aging, endothelial cells lying on the inner surface of the blood vessels present a senescent phonotype, triggering and accelerating atherosclerosis development. The anti-aging activity of SIRT1, a NAD-dependent deacetylase, is lost the during the occurrence of endothelial senescence (Cir Res 2010;106:1384-93). The present study aims to investigate the molecular mechanisms underlying the loss-of-SIRT1 function in senescent endothelial cells ... | - |
| dc.language | eng | en_US |
| dc.relation.ispartof | Annual Scientific Meeting of the International Academy of Cardiology & 18th World Congress on Heart Disease | en_US |
| dc.title | CDK5-mediated hyperphosphorylation contributes to the lossof-SIRT1 function during the development of endothelial senescence | en_US |
| dc.type | Conference_Paper | en_US |
| dc.identifier.email | Bai, B: baibohku@hku.hk | en_US |
| dc.identifier.email | Liang, Y: yanliang@hku.hk | en_US |
| dc.identifier.email | Xu, C: xchku@hku.hk | en_US |
| dc.identifier.email | Lee, MYK: leemary@hku.hk | en_US |
| dc.identifier.email | Xu, A: amxu@hkucc.hku.hk | en_US |
| dc.identifier.email | Vanhoutte, PM: vanhoutt@hku.hk | en_US |
| dc.identifier.email | Wang, Y: yuwanghk@hku.hk | en_US |
| dc.identifier.authority | Xu, A=rp00485 | en_US |
| dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
| dc.identifier.authority | Wang, Y=rp00239 | en_US |
| dc.description.nature | postprint | - |
| dc.identifier.hkuros | 233167 | en_US |