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Conference Paper: CDK5-mediated hyperphosphorylation contributes to the lossof-SIRT1 function during the development of endothelial senescence

TitleCDK5-mediated hyperphosphorylation contributes to the lossof-SIRT1 function during the development of endothelial senescence
Authors
Issue Date2013
Citation
The International Academy of Cardiology 18th World Congress on Heart Disease Annual Scientific Sessions 2013, Vancouver, BC., Canada, 26-29 July 2013. How to Cite?
AbstractBACKGROUND: During vascular aging, endothelial cells lying on the inner surface of the blood vessels present a senescent phonotype, triggering and accelerating atherosclerosis development. The anti-aging activity of SIRT1, a NAD-dependent deacetylase, is lost the during the occurrence of endothelial senescence (Cir Res 2010;106:1384-93). The present study aims to investigate the molecular mechanisms underlying the loss-of-SIRT1 function in senescent endothelial cells ...
DescriptionSession S29 - Molecular and Cellular Cardiology / Vascular Biology, Basic Research: abstract no. 250
Persistent Identifierhttp://hdl.handle.net/10722/201277

 

DC FieldValueLanguage
dc.contributor.authorBai, Ben_US
dc.contributor.authorLiang, Yen_US
dc.contributor.authorXu, Cen_US
dc.contributor.authorLee, MYKen_US
dc.contributor.authorXu, Aen_US
dc.contributor.authorWu, DHen_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorWang, Yen_US
dc.date.accessioned2014-08-21T07:20:17Z-
dc.date.available2014-08-21T07:20:17Z-
dc.date.issued2013en_US
dc.identifier.citationThe International Academy of Cardiology 18th World Congress on Heart Disease Annual Scientific Sessions 2013, Vancouver, BC., Canada, 26-29 July 2013.en_US
dc.identifier.urihttp://hdl.handle.net/10722/201277-
dc.descriptionSession S29 - Molecular and Cellular Cardiology / Vascular Biology, Basic Research: abstract no. 250-
dc.description.abstractBACKGROUND: During vascular aging, endothelial cells lying on the inner surface of the blood vessels present a senescent phonotype, triggering and accelerating atherosclerosis development. The anti-aging activity of SIRT1, a NAD-dependent deacetylase, is lost the during the occurrence of endothelial senescence (Cir Res 2010;106:1384-93). The present study aims to investigate the molecular mechanisms underlying the loss-of-SIRT1 function in senescent endothelial cells ...-
dc.languageengen_US
dc.relation.ispartofInternational Academy of Cardiology 18th World Congress on Heart Disease Annual Scientific Sessions 2013en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleCDK5-mediated hyperphosphorylation contributes to the lossof-SIRT1 function during the development of endothelial senescenceen_US
dc.typeConference_Paperen_US
dc.identifier.emailBai, B: baibohku@hku.hken_US
dc.identifier.emailLiang, Y: yanliang@hku.hken_US
dc.identifier.emailXu, C: xchku@hku.hken_US
dc.identifier.emailLee, MYK: leemary@hku.hken_US
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_US
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_US
dc.identifier.emailWang, Y: yuwanghk@hku.hken_US
dc.identifier.authorityXu, A=rp00485en_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.identifier.authorityWang, Y=rp00239en_US
dc.description.naturepostprint-
dc.identifier.hkuros233167en_US

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