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Article: Hedgehog and notch signaling in enteric nervous system development

TitleHedgehog and notch signaling in enteric nervous system development
Authors
Issue Date2014
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG
Citation
Neurosignals, 2014, v. 22 n. 1, p. 1-13 How to Cite?
AbstractThe enteric nervous system (ENS) in mammals is derived from a small pool of progenitor cells, namely enteric neural crest cells (NCCs). These precursor cells proliferate extensively to expand, migrate over a long distance to fully colonize the developing gut and differentiate into millions of neurons and glia to form a functional ENS for regulating the complex behaviors of the gut. This developmental process relies on a precise regulation of the neuronal and glial differentiation and requires an appropriate balance between the migration, proliferation and differentiation of enteric NCCs and their progeny. Hedgehog (Hh) and Notch signalings are essential for almost every aspect of ENS development, and they confer both the long- and short-range signals to coordinate these seemingly diverse cellular processes. In this review, we summarize the roles of Hh and Notch signaling, particularly in the context of gut organogenesis and ENS development and emphasize how combinatory Hh and Notch signaling renders functional diversity as well as specificity. © 2013 S. Karger AG, Basel
Persistent Identifierhttp://hdl.handle.net/10722/200960
ISSN
2015 Impact Factor: 1.593
2015 SCImago Journal Rankings: 0.763
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, JAen_US
dc.contributor.authorNgan, ESWen_US
dc.date.accessioned2014-08-21T07:07:44Z-
dc.date.available2014-08-21T07:07:44Z-
dc.date.issued2014en_US
dc.identifier.citationNeurosignals, 2014, v. 22 n. 1, p. 1-13en_US
dc.identifier.issn1424-862X-
dc.identifier.urihttp://hdl.handle.net/10722/200960-
dc.description.abstractThe enteric nervous system (ENS) in mammals is derived from a small pool of progenitor cells, namely enteric neural crest cells (NCCs). These precursor cells proliferate extensively to expand, migrate over a long distance to fully colonize the developing gut and differentiate into millions of neurons and glia to form a functional ENS for regulating the complex behaviors of the gut. This developmental process relies on a precise regulation of the neuronal and glial differentiation and requires an appropriate balance between the migration, proliferation and differentiation of enteric NCCs and their progeny. Hedgehog (Hh) and Notch signalings are essential for almost every aspect of ENS development, and they confer both the long- and short-range signals to coordinate these seemingly diverse cellular processes. In this review, we summarize the roles of Hh and Notch signaling, particularly in the context of gut organogenesis and ENS development and emphasize how combinatory Hh and Notch signaling renders functional diversity as well as specificity. © 2013 S. Karger AG, Basel-
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG-
dc.relation.ispartofNeurosignalsen_US
dc.rightsNeurosignals. Copyright © S Karger AG.-
dc.titleHedgehog and notch signaling in enteric nervous system developmenten_US
dc.typeArticleen_US
dc.identifier.emailNgan, ESW: engan@hku.hken_US
dc.identifier.authorityNgan, ESW=rp00422en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1159/000356305-
dc.identifier.pmid24356576-
dc.identifier.hkuros233749en_US
dc.identifier.volume22en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage13en_US
dc.identifier.isiWOS:000342731200001-
dc.publisher.placeSwitzerland-

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