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Article: Activation of postsynaptic 5-HT1A receptors improve stress adaptation

TitleActivation of postsynaptic 5-HT1A receptors improve stress adaptation
Authors
KeywordsStress
5-HT1A receptor
8-OH-DPAT
WAY 100635
Hippocampus
Issue Date2014
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00213/index.htm
Citation
Psychopharmacology, 2014, v. 231 n. 10, p. 2067-2075 How to Cite?
AbstractRationale: Serotonin-1A (5-HT1A) receptors modulate the stress response and have been implicated in the etiology and treatment of depression and anxiety disorders. A reduction in postsynaptic 5-HT1A receptor function in limbic areas has consistently been observed following exposure to chronic stress. Objectives: To investigate the hypothesis that increased activation of 5-HT1A receptors in rats having reduced 5-HT function may improve stress adaptation and the behavioral sequelae commonly associated with chronic stress. Methods: One hundred forty-four Sprague–Dawley rats received injections of para-chlorophenylalanine to partially deplete 5-HT then were given daily systemic pretreatment with the 5-HT1A receptor agonist, 8-hydroxy-2- (di-n-propylamino) tetralin (8-OH-DPAT), the antagonist, WAY 100635, or vehicle prior to either restraint stress (6 h/day for 10 daily sessions) or control conditions. Anxiety- and depressive-like behaviors were then assessed using the open field and sucrose preference tests. Protein level of hippocampal glucocorticoid receptors (GR) and mineralocorticoid receptors was detected by immunohistochemistry and brain-derived neurotrophic factor (BDNF) was determined by in situ hybridization. Results: 8-OH-DPAT pretreatment prior to stress exposure attenuated later stress-induced anxiety- and depression-like behaviors and increased GR and BDNF mRNA expression in the hippocampus relative to vehicle- and WAY 100635-pretreated, stressed animals. Conclusion: The stress-related impairments associated with 5-HT deficiency can be improved by 8-OH-DPAT pretreatment prior to stress exposure and are associated with an augmentation of GR-like immunoreactivity and BDNF mRNA expression in the hippocampus. It suggested that selective activation of 5-HT1A receptors may be a potential treatment strategy for stress-related disorders such as anxiety and depression.
Persistent Identifierhttp://hdl.handle.net/10722/200822
ISSN
2017 Impact Factor: 3.222
2015 SCImago Journal Rankings: 1.687
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, J-
dc.contributor.authorCao, X-
dc.contributor.authorMar, AC-
dc.contributor.authorDing, Y-
dc.contributor.authorWang, X-
dc.contributor.authorLi, Q-
dc.contributor.authorLi, L-
dc.date.accessioned2014-08-21T07:02:40Z-
dc.date.available2014-08-21T07:02:40Z-
dc.date.issued2014-
dc.identifier.citationPsychopharmacology, 2014, v. 231 n. 10, p. 2067-2075-
dc.identifier.issn0033-3158-
dc.identifier.urihttp://hdl.handle.net/10722/200822-
dc.description.abstractRationale: Serotonin-1A (5-HT1A) receptors modulate the stress response and have been implicated in the etiology and treatment of depression and anxiety disorders. A reduction in postsynaptic 5-HT1A receptor function in limbic areas has consistently been observed following exposure to chronic stress. Objectives: To investigate the hypothesis that increased activation of 5-HT1A receptors in rats having reduced 5-HT function may improve stress adaptation and the behavioral sequelae commonly associated with chronic stress. Methods: One hundred forty-four Sprague–Dawley rats received injections of para-chlorophenylalanine to partially deplete 5-HT then were given daily systemic pretreatment with the 5-HT1A receptor agonist, 8-hydroxy-2- (di-n-propylamino) tetralin (8-OH-DPAT), the antagonist, WAY 100635, or vehicle prior to either restraint stress (6 h/day for 10 daily sessions) or control conditions. Anxiety- and depressive-like behaviors were then assessed using the open field and sucrose preference tests. Protein level of hippocampal glucocorticoid receptors (GR) and mineralocorticoid receptors was detected by immunohistochemistry and brain-derived neurotrophic factor (BDNF) was determined by in situ hybridization. Results: 8-OH-DPAT pretreatment prior to stress exposure attenuated later stress-induced anxiety- and depression-like behaviors and increased GR and BDNF mRNA expression in the hippocampus relative to vehicle- and WAY 100635-pretreated, stressed animals. Conclusion: The stress-related impairments associated with 5-HT deficiency can be improved by 8-OH-DPAT pretreatment prior to stress exposure and are associated with an augmentation of GR-like immunoreactivity and BDNF mRNA expression in the hippocampus. It suggested that selective activation of 5-HT1A receptors may be a potential treatment strategy for stress-related disorders such as anxiety and depression.-
dc.languageeng-
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00213/index.htm-
dc.relation.ispartofPsychopharmacology-
dc.rightsThe final publication is available at Springer via http://dx.doi.org/10.1007/s00213-013-3350-z-
dc.subjectStress-
dc.subject5-HT1A receptor-
dc.subject8-OH-DPAT-
dc.subjectWAY 100635-
dc.subjectHippocampus-
dc.titleActivation of postsynaptic 5-HT1A receptors improve stress adaptation-
dc.typeArticle-
dc.identifier.emailLi, Q: liqi@hkucc.hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00213-013-3350-z-
dc.identifier.pmid24258351-
dc.identifier.scopuseid_2-s2.0-84900849743-
dc.identifier.hkuros232163-
dc.identifier.volume231-
dc.identifier.issue10-
dc.identifier.spage2067-
dc.identifier.epage2075-
dc.identifier.isiWOS:000335166500003-
dc.publisher.placeGermany-

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