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Article: pIMP-PH114 carrying bla IMP-4 in a Klebsiella pneumoniae strain is closely related to other multidrug-resistant IncA/C2 plasmids.

TitlepIMP-PH114 carrying bla IMP-4 in a Klebsiella pneumoniae strain is closely related to other multidrug-resistant IncA/C2 plasmids.
Authors
Issue Date2014
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00284/
Citation
Current Microbiology, 2014, v. 68 n. 2, p. 227-232 How to Cite?
AbstractThe IncA/C plasmids are broad host-range vehicles which have been associated with wide dissemination of CMY-2 among Enterobacteriaceae of human and animal origins. Acquired metallo-β-lactamases (MBLs) such as the IMP-type enzymes are increasingly reported in multidrug-resistant Gram-negative bacteria worldwide, particularly in Enterobacteriaceae. We described the complete sequence of the first IMP-4-encoding IncA/C2 plasmid, pIMP-PH114 (151,885 bp), from a sequence type 1 Klebsiella pneumoniae strain that was recovered from a patient who was hospitalized in the Philippines. pIMP-PH114 consists of a backbone from the IncA/C2 plasmids, with the insertion of a novel Tn21-like class 1 integron composite structure (containing the cassette array bla IMP-4-qacG-aacA4-catB3, followed by a class C β-lactamase bla DHA-1 and the mercury resistance operon, merRTPCADE) and a sul2-floR encoding region. Phylogenetic analysis of the IncA/C repA sequences showed that pIMP-PH114 formed a subgroup with other IncA/C plasmids involved in the international spread of CMY-2, TEM-24 and NDM-1. Identical bla IMP-4 arrays have been described among different Enterobacteriaceae and Acinetobacter spp. in China, Singapore and Australia but the genetic context is different. The broad host range of IncA/C plasmids may have facilitated dissemination of the bla IMP-4 arrays among different diverse groups of bacteria.
Persistent Identifierhttp://hdl.handle.net/10722/200729
ISSN
2015 Impact Factor: 1.519
2015 SCImago Journal Rankings: 0.591
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, PL-
dc.contributor.authorLo, WU-
dc.contributor.authorChan, J-
dc.contributor.authorCHEUNG, YY-
dc.contributor.authorChow, KH-
dc.contributor.authorYam, WC-
dc.contributor.authorLin, C-
dc.contributor.authorQue, TL-
dc.date.accessioned2014-08-21T06:58:01Z-
dc.date.available2014-08-21T06:58:01Z-
dc.date.issued2014-
dc.identifier.citationCurrent Microbiology, 2014, v. 68 n. 2, p. 227-232-
dc.identifier.issn0343-8651-
dc.identifier.urihttp://hdl.handle.net/10722/200729-
dc.description.abstractThe IncA/C plasmids are broad host-range vehicles which have been associated with wide dissemination of CMY-2 among Enterobacteriaceae of human and animal origins. Acquired metallo-β-lactamases (MBLs) such as the IMP-type enzymes are increasingly reported in multidrug-resistant Gram-negative bacteria worldwide, particularly in Enterobacteriaceae. We described the complete sequence of the first IMP-4-encoding IncA/C2 plasmid, pIMP-PH114 (151,885 bp), from a sequence type 1 Klebsiella pneumoniae strain that was recovered from a patient who was hospitalized in the Philippines. pIMP-PH114 consists of a backbone from the IncA/C2 plasmids, with the insertion of a novel Tn21-like class 1 integron composite structure (containing the cassette array bla IMP-4-qacG-aacA4-catB3, followed by a class C β-lactamase bla DHA-1 and the mercury resistance operon, merRTPCADE) and a sul2-floR encoding region. Phylogenetic analysis of the IncA/C repA sequences showed that pIMP-PH114 formed a subgroup with other IncA/C plasmids involved in the international spread of CMY-2, TEM-24 and NDM-1. Identical bla IMP-4 arrays have been described among different Enterobacteriaceae and Acinetobacter spp. in China, Singapore and Australia but the genetic context is different. The broad host range of IncA/C plasmids may have facilitated dissemination of the bla IMP-4 arrays among different diverse groups of bacteria.-
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00284/-
dc.relation.ispartofCurrent Microbiology-
dc.rightsThe final publication is available at Springer via http://dx.doi.org/[insert DOI]-
dc.titlepIMP-PH114 carrying bla IMP-4 in a Klebsiella pneumoniae strain is closely related to other multidrug-resistant IncA/C2 plasmids.-
dc.typeArticle-
dc.identifier.emailHo, PL: plho@hkucc.hku.hk-
dc.identifier.emailLo, WU: stephlo@hku.hk-
dc.identifier.emailChan, J: chanjane@hku.hk-
dc.identifier.emailChow, KH: khchowb@hku.hk-
dc.identifier.emailYam, WC: wcyam@hkucc.hku.hk-
dc.identifier.emailLin, C: nicklin@hku.hk-
dc.identifier.authorityHo, PL=rp00406-
dc.identifier.authorityChow, KH=rp00370-
dc.identifier.authorityYam, WC=rp00313-
dc.identifier.doi10.1007/s00284-013-0471-x-
dc.identifier.pmid24121549-
dc.identifier.scopuseid_2-s2.0-84898917945-
dc.identifier.hkuros233003-
dc.identifier.volume68-
dc.identifier.issue2-
dc.identifier.spage227-
dc.identifier.epage232-
dc.identifier.isiWOS:000329994500015-
dc.publisher.placeUnited States-

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