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Article: Platelet 5-HT1A receptor correlates with major depressive disorder in drug-free patients

TitlePlatelet 5-HT1A receptor correlates with major depressive disorder in drug-free patients
Authors
Issue Date2014
PublisherElsevier. The Journal's web site is located at http://www.elsevier.com/locate/pnpbp
Citation
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2014, v. 53, p. 74-79 How to Cite?
AbstractThe platelet serotonergic system has potential biomarker utility for major depressive disorder (MDD). In the present study, platelet expression of 5-HT1A receptors and serotonin transporter (SERT) proteins, and serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) were quantified in 53 patients with MDD and 22 unaffected controls. All were drug-free, non-smokers and had no other psychiatric and cardiovascular comorbidity. The severity of depression symptoms was evaluated using the 17-item Hamilton Depression Rating Scale (HAMD-17) and the Self-rating Depression Scale (SDS). Patients with MDD had significantly higher expression of platelet 5-HT1A receptors but significantly lower contents of platelet 5-HT, platelet-poor plasma (PPP) 5-HT and PPP 5-HIAA compared to healthy controls, and this was correlated with the severity of depression. SERT expression did not differ between the two groups. Correlation analysis confirmed a strong, inverse relationship between the 5-HT1A receptor expression and the 5-HT and 5-HIAA levels. Thus overexpression of platelet 5-HT1A receptors and reduced 5-HT tone may function as a peripheral marker of depression.
Persistent Identifierhttp://hdl.handle.net/10722/200681
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Zen_US
dc.contributor.authorWANG, Den_US
dc.contributor.authorMan, MSCen_US
dc.contributor.authorNg, Ren_US
dc.contributor.authorMcAlonan, GMen_US
dc.contributor.authorWong, HKen_US
dc.contributor.authorWong, Wen_US
dc.contributor.authorLee, Jen_US
dc.contributor.authorTan, QRen_US
dc.date.accessioned2014-08-21T06:55:04Z-
dc.date.available2014-08-21T06:55:04Z-
dc.date.issued2014en_US
dc.identifier.citationProgress in Neuro-Psychopharmacology & Biological Psychiatry, 2014, v. 53, p. 74-79en_US
dc.identifier.urihttp://hdl.handle.net/10722/200681-
dc.description.abstractThe platelet serotonergic system has potential biomarker utility for major depressive disorder (MDD). In the present study, platelet expression of 5-HT1A receptors and serotonin transporter (SERT) proteins, and serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) were quantified in 53 patients with MDD and 22 unaffected controls. All were drug-free, non-smokers and had no other psychiatric and cardiovascular comorbidity. The severity of depression symptoms was evaluated using the 17-item Hamilton Depression Rating Scale (HAMD-17) and the Self-rating Depression Scale (SDS). Patients with MDD had significantly higher expression of platelet 5-HT1A receptors but significantly lower contents of platelet 5-HT, platelet-poor plasma (PPP) 5-HT and PPP 5-HIAA compared to healthy controls, and this was correlated with the severity of depression. SERT expression did not differ between the two groups. Correlation analysis confirmed a strong, inverse relationship between the 5-HT1A receptor expression and the 5-HT and 5-HIAA levels. Thus overexpression of platelet 5-HT1A receptors and reduced 5-HT tone may function as a peripheral marker of depression.en_US
dc.languageengen_US
dc.publisherElsevier. The Journal's web site is located at http://www.elsevier.com/locate/pnpbpen_US
dc.relation.ispartofProgress in Neuro-Psychopharmacology & Biological Psychiatryen_US
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in <Journal title>. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#, ISSUE#, (DATE)] DOI#en_US
dc.titlePlatelet 5-HT1A receptor correlates with major depressive disorder in drug-free patientsen_US
dc.typeArticleen_US
dc.identifier.emailZhang, Z: zhangzj@hkucc.hku.hken_US
dc.identifier.emailMan, MSC: marksman@hku.hken_US
dc.identifier.emailWong, HK: hkwong@hku.hken_US
dc.identifier.emailWong, W: wwong110@hku.hken_US
dc.identifier.authorityZhang, Z=rp01297en_US
dc.identifier.doi10.1016/j.pnpbp.2014.03.004en_US
dc.identifier.pmid24657886-
dc.identifier.hkuros232616en_US
dc.identifier.volume53en_US
dc.identifier.spage74en_US
dc.identifier.epage79en_US
dc.identifier.isiWOS:000338813600010-

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