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Article: IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut

TitleIL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut
Authors
KeywordsIL-10
Regulatory B cell
Mucosal inflammation
IL-33
IBD
Breg
Issue Date2014
Citation
Journal of Autoimmunity, 2014, v. 50, p. 107-122 How to Cite?
AbstractRegulatory B cells (Breg) have attracted increasing attention for their roles in maintaining peripheral tolerance. Interleukin 33 (IL-33) is a recently identified IL-1 family member, which leads a double-life with both pro- and anti-inflammatory properties. We report here that peritoneal injection of IL-33 exacerbated inflammatory bowel disease in IL-10-deficient (IL-10-/-) mice, whereas IL-33-treated IL-10-sufficient (wild type) mice were protected from the disease induction. A phenotypically unconventional subset(s) (CD19+CD25+CD1dhiIgMhiCD5-CD23-Tim-1-) of IL-10 producing Breg-like cells (BregIL-33) was identified responsible for the protection. We demonstrated further that BregIL-33 isolated from these mice could suppress immune effector cell expansion and functions and, upon adoptive transfer, effectively blocked the development of spontaneous colitis in IL-10-/- mice. Our findings indicate an essential protective role, hence therapeutic potential, of BregIL-33 against mucosal inflammatory disorders in thegut. © 2014.
Persistent Identifierhttp://hdl.handle.net/10722/200152
ISSN
2015 Impact Factor: 7.76
2015 SCImago Journal Rankings: 1.971
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSattler, Susanne-
dc.contributor.authorLing, Guangsheng-
dc.contributor.authorXu, Damo-
dc.contributor.authorHussaarts, Leonie-
dc.contributor.authorRomaine, Andreas-
dc.contributor.authorZhao, Hongzhi-
dc.contributor.authorFossati-Jimack, Liliane-
dc.contributor.authorMalik, Talat H.-
dc.contributor.authorCook, Herbert Terence-
dc.contributor.authorBotto, Marina B.-
dc.contributor.authorLau, Yu Lung-
dc.contributor.authorSmits, Hermelijn H.-
dc.contributor.authorLiew, Fooyew-
dc.contributor.authorHuang, Fangping-
dc.date.accessioned2014-07-26T23:11:12Z-
dc.date.available2014-07-26T23:11:12Z-
dc.date.issued2014-
dc.identifier.citationJournal of Autoimmunity, 2014, v. 50, p. 107-122-
dc.identifier.issn0896-8411-
dc.identifier.urihttp://hdl.handle.net/10722/200152-
dc.description.abstractRegulatory B cells (Breg) have attracted increasing attention for their roles in maintaining peripheral tolerance. Interleukin 33 (IL-33) is a recently identified IL-1 family member, which leads a double-life with both pro- and anti-inflammatory properties. We report here that peritoneal injection of IL-33 exacerbated inflammatory bowel disease in IL-10-deficient (IL-10-/-) mice, whereas IL-33-treated IL-10-sufficient (wild type) mice were protected from the disease induction. A phenotypically unconventional subset(s) (CD19+CD25+CD1dhiIgMhiCD5-CD23-Tim-1-) of IL-10 producing Breg-like cells (BregIL-33) was identified responsible for the protection. We demonstrated further that BregIL-33 isolated from these mice could suppress immune effector cell expansion and functions and, upon adoptive transfer, effectively blocked the development of spontaneous colitis in IL-10-/- mice. Our findings indicate an essential protective role, hence therapeutic potential, of BregIL-33 against mucosal inflammatory disorders in thegut. © 2014.-
dc.languageeng-
dc.relation.ispartofJournal of Autoimmunity-
dc.subjectIL-10-
dc.subjectRegulatory B cell-
dc.subjectMucosal inflammation-
dc.subjectIL-33-
dc.subjectIBD-
dc.subjectBreg-
dc.titleIL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jaut.2014.01.032-
dc.identifier.pmid24491821-
dc.identifier.scopuseid_2-s2.0-84899106298-
dc.identifier.hkuros234965-
dc.identifier.volume50-
dc.identifier.spage107-
dc.identifier.epage122-
dc.identifier.eissn1095-9157-
dc.identifier.isiWOS:000336114600014-

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