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Article: High expression of the autophagy gene Beclin-1 is associated with favorable prognosis for salivary gland adenoid cystic carcinoma

TitleHigh expression of the autophagy gene Beclin-1 is associated with favorable prognosis for salivary gland adenoid cystic carcinoma
Authors
KeywordsAdenoid cystic carcinoma
Prognosis
Metastasis
Death-associated protein kinase-1
Beclin-1
Autophagy
Ultraviolet radiation resistance-associated gene
Pten
Issue Date2012
Citation
Journal of Oral Pathology and Medicine, 2012, v. 41, n. 8, p. 621-629 How to Cite?
AbstractBackground: Although autophagy is universally involved in tumorigenesis and tumor progression, the roles of autophagy and autophagy-regulating genes in salivary gland adenoid cystic carcinoma (ACC) remain unknown. In this study, we investigated the expression of the autophagy-regulating genes Beclin-1, death-associated protein kinase-1, ultraviolet radiation resistance-associated gene, and phosphatase and tensin homolog in salivary gland ACC samples. Methods: Immunohistochemistry and real-time polymerase chain reaction were used to analyze the expression of these genes in 89 ACC samples and normal salivary gland tissue samples. The relationship of their expression with clinicopathological features was analyzed. Results: The data showed significantly lower expression of these genes in the tumor samples than in normal salivary gland tissue samples. Furthermore, Beclin-1 expression was significantly correlated with histological pattern of ACC (P<0.05), and high expression of ultraviolet radiation resistance-associated gene was associated with distant metastasis (P<0.05). Most importantly, univariate and multivariate survival analyses suggested that Beclin-1 protein and mRNA expression in cancer cells were independent prognostic indicators for ACC. Conclusion: Our results suggest that autophagy-regulating genes may participate in the pathogenesis of salivary gland ACC. Further research will be required to gain a better understanding of autophagy in ACC. © 2012 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/200124
ISSN
2015 Impact Factor: 1.859
2015 SCImago Journal Rankings: 0.731
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiang, Lizhong-
dc.contributor.authorMa, Ben-
dc.contributor.authorLiang, Yujie-
dc.contributor.authorLiu, Haichao-
dc.contributor.authorZheng, Guangsen-
dc.contributor.authorZhang, Tonghan-
dc.contributor.authorChu, Mei-
dc.contributor.authorXu, Pingping-
dc.contributor.authorSu, Yuxiong-
dc.contributor.authorLiao, Guiqing-
dc.date.accessioned2014-07-26T23:11:10Z-
dc.date.available2014-07-26T23:11:10Z-
dc.date.issued2012-
dc.identifier.citationJournal of Oral Pathology and Medicine, 2012, v. 41, n. 8, p. 621-629-
dc.identifier.issn0904-2512-
dc.identifier.urihttp://hdl.handle.net/10722/200124-
dc.description.abstractBackground: Although autophagy is universally involved in tumorigenesis and tumor progression, the roles of autophagy and autophagy-regulating genes in salivary gland adenoid cystic carcinoma (ACC) remain unknown. In this study, we investigated the expression of the autophagy-regulating genes Beclin-1, death-associated protein kinase-1, ultraviolet radiation resistance-associated gene, and phosphatase and tensin homolog in salivary gland ACC samples. Methods: Immunohistochemistry and real-time polymerase chain reaction were used to analyze the expression of these genes in 89 ACC samples and normal salivary gland tissue samples. The relationship of their expression with clinicopathological features was analyzed. Results: The data showed significantly lower expression of these genes in the tumor samples than in normal salivary gland tissue samples. Furthermore, Beclin-1 expression was significantly correlated with histological pattern of ACC (P<0.05), and high expression of ultraviolet radiation resistance-associated gene was associated with distant metastasis (P<0.05). Most importantly, univariate and multivariate survival analyses suggested that Beclin-1 protein and mRNA expression in cancer cells were independent prognostic indicators for ACC. Conclusion: Our results suggest that autophagy-regulating genes may participate in the pathogenesis of salivary gland ACC. Further research will be required to gain a better understanding of autophagy in ACC. © 2012 John Wiley & Sons A/S.-
dc.languageeng-
dc.relation.ispartofJournal of Oral Pathology and Medicine-
dc.subjectAdenoid cystic carcinoma-
dc.subjectPrognosis-
dc.subjectMetastasis-
dc.subjectDeath-associated protein kinase-1-
dc.subjectBeclin-1-
dc.subjectAutophagy-
dc.subjectUltraviolet radiation resistance-associated gene-
dc.subjectPten-
dc.titleHigh expression of the autophagy gene Beclin-1 is associated with favorable prognosis for salivary gland adenoid cystic carcinoma-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-0714.2012.01171.x-
dc.identifier.pmid22712799-
dc.identifier.scopuseid_2-s2.0-84865539155-
dc.identifier.volume41-
dc.identifier.issue8-
dc.identifier.spage621-
dc.identifier.epage629-
dc.identifier.eissn1600-0714-
dc.identifier.isiWOS:000307959000008-

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