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Article: Protective effect of serum antibodies against a 110-kilodalton protein of Actinobacillus actinomycetemcomitans following periodontal therapy

TitleProtective effect of serum antibodies against a 110-kilodalton protein of Actinobacillus actinomycetemcomitans following periodontal therapy
Authors
KeywordsImmune response
Actinobacillus actinomycetemcomitans
Antigen
Antibody
Issue Date1999
Citation
Oral Microbiology and Immunology, 1999, v. 14, n. 5, p. 281-287 How to Cite?
AbstractThirty-four adult patients with untreated periodontitis were randomly assigned to receive full mouth scaling alone or scaling with an adjunctive antimicrobial therapy, both followed by supportive periodontal therapy. At 24 months, specific serum immunoglobulin A (IgA), IgG and IgG subclass antibody reactivities against a 110-kDa protein of Actinobacillus actinomycetemcomitans were assessed by Western blot. In patients harboring A, actinomycetemcomitans intraorally, the IgG4 antibody reactivity against the 110-kDa protein of A. actinomycetemcomitans was associated with significantly increased survival rates of teeth and of sites not exhibiting 2 mm or more of probing attachment loss. The same trend was found for IgG3 and IgG2 antibody reactivities, but it was statistically insignificant. No association with clinical treatment outcome was observed for IgA, IgG and IgG~1 antibody reactivities. The results indicated that systemic IgG~4 antibody reactivity against the 110-kDa protein of A. actinomycetemcomitans may have a protective effect against periodontal disease progression in patients harboring A. actinomycetemcomitans and receiving periodontal therapy.
Persistent Identifierhttp://hdl.handle.net/10722/200072
ISSN
2011 Impact Factor: 2.807
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBeikler, Thomas-
dc.contributor.authorKarch, Helge W.-
dc.contributor.authorEhmke, Benjamin-
dc.contributor.authorKlaiber, Bernd-
dc.contributor.authorFlemmig, Thomas Frank-
dc.date.accessioned2014-07-26T23:11:06Z-
dc.date.available2014-07-26T23:11:06Z-
dc.date.issued1999-
dc.identifier.citationOral Microbiology and Immunology, 1999, v. 14, n. 5, p. 281-287-
dc.identifier.issn0902-0055-
dc.identifier.urihttp://hdl.handle.net/10722/200072-
dc.description.abstractThirty-four adult patients with untreated periodontitis were randomly assigned to receive full mouth scaling alone or scaling with an adjunctive antimicrobial therapy, both followed by supportive periodontal therapy. At 24 months, specific serum immunoglobulin A (IgA), IgG and IgG subclass antibody reactivities against a 110-kDa protein of Actinobacillus actinomycetemcomitans were assessed by Western blot. In patients harboring A, actinomycetemcomitans intraorally, the IgG4 antibody reactivity against the 110-kDa protein of A. actinomycetemcomitans was associated with significantly increased survival rates of teeth and of sites not exhibiting 2 mm or more of probing attachment loss. The same trend was found for IgG3 and IgG2 antibody reactivities, but it was statistically insignificant. No association with clinical treatment outcome was observed for IgA, IgG and IgG~1 antibody reactivities. The results indicated that systemic IgG~4 antibody reactivity against the 110-kDa protein of A. actinomycetemcomitans may have a protective effect against periodontal disease progression in patients harboring A. actinomycetemcomitans and receiving periodontal therapy.-
dc.languageeng-
dc.relation.ispartofOral Microbiology and Immunology-
dc.subjectImmune response-
dc.subjectActinobacillus actinomycetemcomitans-
dc.subjectAntigen-
dc.subjectAntibody-
dc.titleProtective effect of serum antibodies against a 110-kilodalton protein of Actinobacillus actinomycetemcomitans following periodontal therapy-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1034/j.1399-302X.1999.140503.x-
dc.identifier.pmid10551154-
dc.identifier.scopuseid_2-s2.0-0033214163-
dc.identifier.volume14-
dc.identifier.issue5-
dc.identifier.spage281-
dc.identifier.epage287-
dc.identifier.isiWOS:000082545900003-

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