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- Publisher Website: 10.1128/CDLI.3.6.678-681.1996
- Scopus: eid_2-s2.0-0029908340
- PMID: 8914758
- WOS: WOS:A1996VQ35100010
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Article: Specific antibody reactivity against a 110-kilodalton Actinobacillus actinomycetemcomitans protein in subjects with periodontitis
Title | Specific antibody reactivity against a 110-kilodalton Actinobacillus actinomycetemcomitans protein in subjects with periodontitis |
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Authors | |
Issue Date | 1996 |
Citation | Clinical and Diagnostic Laboratory Immunology, 1996, v. 3, n. 6, p. 678-681 How to Cite? |
Abstract | The purpose of the present study was to determine the serum immunoglobulin A (IgA), IgM, and IgG reactivities against proteins of Actinobacillus actinomycetemcomitans in patients with periodontitis. Serum samples from 20 patients with early-onset periodontitis, 20 patients with adult periodontitis, and 20 age- and sex-matched healthy controls were assessed by immunoblot analysis. IgG antibody reactivity against a sarcosyl-insoluble 110-kDa protein of A. actinomycetemcomitans was detected in 65 and 45% of patients, with early-onset periodontitis and adult peritonitis, respectively, and IgA antibodies against this protein were found in 70 and 55% of these patients, respectively. However, control subjects showed no IgG reactivity, and IgA antibodies against the sarcosyl-insoluble 110-kDa protein were detected in only 5% of the patients (P < 0.05). There was no IgM antibody reactivity against this protein in any of the diseased or healthy subjects. The sensitivity and specificity of serum IgA antibody reactivity against the 110-kDa protein in detecting subgingival A. actinomycetemcomitans infection, as determined by PCR, were 77 and 66%, respectively. The results of the study indicated that the sarcosyl-insoluble 110-kDa protein is a potential candidate for use in the serodiagnosis of periodontal disease. |
Persistent Identifier | http://hdl.handle.net/10722/200053 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Flemmig, Thomas Frank | - |
dc.contributor.author | Selmair, I. | - |
dc.contributor.author | Schmidt, Herbert H. | - |
dc.contributor.author | Karch, Helge W. | - |
dc.date.accessioned | 2014-07-26T23:11:04Z | - |
dc.date.available | 2014-07-26T23:11:04Z | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | Clinical and Diagnostic Laboratory Immunology, 1996, v. 3, n. 6, p. 678-681 | - |
dc.identifier.issn | 1071-412X | - |
dc.identifier.uri | http://hdl.handle.net/10722/200053 | - |
dc.description.abstract | The purpose of the present study was to determine the serum immunoglobulin A (IgA), IgM, and IgG reactivities against proteins of Actinobacillus actinomycetemcomitans in patients with periodontitis. Serum samples from 20 patients with early-onset periodontitis, 20 patients with adult periodontitis, and 20 age- and sex-matched healthy controls were assessed by immunoblot analysis. IgG antibody reactivity against a sarcosyl-insoluble 110-kDa protein of A. actinomycetemcomitans was detected in 65 and 45% of patients, with early-onset periodontitis and adult peritonitis, respectively, and IgA antibodies against this protein were found in 70 and 55% of these patients, respectively. However, control subjects showed no IgG reactivity, and IgA antibodies against the sarcosyl-insoluble 110-kDa protein were detected in only 5% of the patients (P < 0.05). There was no IgM antibody reactivity against this protein in any of the diseased or healthy subjects. The sensitivity and specificity of serum IgA antibody reactivity against the 110-kDa protein in detecting subgingival A. actinomycetemcomitans infection, as determined by PCR, were 77 and 66%, respectively. The results of the study indicated that the sarcosyl-insoluble 110-kDa protein is a potential candidate for use in the serodiagnosis of periodontal disease. | - |
dc.language | eng | - |
dc.relation.ispartof | Clinical and Diagnostic Laboratory Immunology | - |
dc.title | Specific antibody reactivity against a 110-kilodalton Actinobacillus actinomycetemcomitans protein in subjects with periodontitis | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1128/CDLI.3.6.678-681.1996 | - |
dc.identifier.pmid | 8914758 | - |
dc.identifier.scopus | eid_2-s2.0-0029908340 | - |
dc.identifier.volume | 3 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 678 | - |
dc.identifier.epage | 681 | - |
dc.identifier.isi | WOS:A1996VQ35100010 | - |
dc.identifier.issnl | 1071-412X | - |