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Article: Neoadjuvant chemotherapy of cisplatin and fluorouracil regimen in head and neck squamous cell carcinoma: A meta-analysis

TitleNeoadjuvant chemotherapy of cisplatin and fluorouracil regimen in head and neck squamous cell carcinoma: A meta-analysis
Authors
KeywordsMeta-analysis
Head and neck
Neoplasm
Neoadjuvant chemotherapy
Issue Date2008
PublisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/
Citation
Chinese Medical Journal, 2008, v. 121, n. 19, p. 1939-1944 How to Cite?
AbstractBackground: The benefit of neoadjuvant chemotherapy in the management of head and neck squamous cell carcinomas (HNSCC) still remains controversial. The aim of this meta-analysis is to evaluate the role of the neoadjuvant chemotherapy with the cisplatin and fluororacil (PF) regimen in enhancing the overall survival of and decreasing locoregional relapse and distant metastasis in HNSCC patients. Methods: Medline and manual searches were performed to identify all published randomized controlled trials (RCTs) investigating the efficacy of the neoadjuvant chemotherapy with the PF regimen. Outcomes assessed by meta-analysis included locoregional relapse, distant metastasis, and overall survival. The odds ratio was the principle measurement of effect, which was calculated as the treatment group (chemotherapy plus locoregional treatment) versus the control group (locoregional treatment alone) and was presented as a point estimate with 95% confidence intervals (CI). Results: Eight RCTs were adopted for analysis. The meta-analysis showed that the odds ratio for the locoregional relapse was 0.92 (0.70-1.22, 95%Cl), which was not statistically significant. The odds ratios for distant metastasis and overall survival were 0.47 (0.33-0.68, 95% Cl) and 1.28 (1.01-1.62, 95% Cl) respectively, which were both statistically significant. Conclusions: Neoadjuvant chemotherapy with the PF regimen in HNSCC patients has no effect on locoregional relapse. However, it shows a small but significant benefit in reducing distant metastasis and improving the overall survival.
Persistent Identifierhttp://hdl.handle.net/10722/199967
ISSN
2015 Impact Factor: 0.957
2015 SCImago Journal Rankings: 0.428
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSu, Yuxiong-
dc.contributor.authorZheng, Jiawei-
dc.contributor.authorZheng, Guangsen-
dc.contributor.authorLiao, Guiqing-
dc.contributor.authorZhang, Zhiyuan-
dc.date.accessioned2014-07-26T23:10:58Z-
dc.date.available2014-07-26T23:10:58Z-
dc.date.issued2008-
dc.identifier.citationChinese Medical Journal, 2008, v. 121, n. 19, p. 1939-1944-
dc.identifier.issn0366-6999-
dc.identifier.urihttp://hdl.handle.net/10722/199967-
dc.description.abstractBackground: The benefit of neoadjuvant chemotherapy in the management of head and neck squamous cell carcinomas (HNSCC) still remains controversial. The aim of this meta-analysis is to evaluate the role of the neoadjuvant chemotherapy with the cisplatin and fluororacil (PF) regimen in enhancing the overall survival of and decreasing locoregional relapse and distant metastasis in HNSCC patients. Methods: Medline and manual searches were performed to identify all published randomized controlled trials (RCTs) investigating the efficacy of the neoadjuvant chemotherapy with the PF regimen. Outcomes assessed by meta-analysis included locoregional relapse, distant metastasis, and overall survival. The odds ratio was the principle measurement of effect, which was calculated as the treatment group (chemotherapy plus locoregional treatment) versus the control group (locoregional treatment alone) and was presented as a point estimate with 95% confidence intervals (CI). Results: Eight RCTs were adopted for analysis. The meta-analysis showed that the odds ratio for the locoregional relapse was 0.92 (0.70-1.22, 95%Cl), which was not statistically significant. The odds ratios for distant metastasis and overall survival were 0.47 (0.33-0.68, 95% Cl) and 1.28 (1.01-1.62, 95% Cl) respectively, which were both statistically significant. Conclusions: Neoadjuvant chemotherapy with the PF regimen in HNSCC patients has no effect on locoregional relapse. However, it shows a small but significant benefit in reducing distant metastasis and improving the overall survival.-
dc.languageeng-
dc.publisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/-
dc.relation.ispartofChinese Medical Journal-
dc.subjectMeta-analysis-
dc.subjectHead and neck-
dc.subjectNeoplasm-
dc.subjectNeoadjuvant chemotherapy-
dc.titleNeoadjuvant chemotherapy of cisplatin and fluorouracil regimen in head and neck squamous cell carcinoma: A meta-analysis-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid19080128-
dc.identifier.scopuseid_2-s2.0-54349118506-
dc.identifier.volume121-
dc.identifier.issue19-
dc.identifier.spage1939-
dc.identifier.epage1944-
dc.identifier.isiWOS:000261200500016-
dc.publisher.placeChina-

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