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Article: Animal Models of Diabetic Retinopathy: Summary and Comparison

TitleAnimal Models of Diabetic Retinopathy: Summary and Comparison
Authors
Issue Date2013
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jdr/
Citation
Journal of Diabetes Research, 2013, v. 2013, article no.106594, p. 1-29 How to Cite?
AbstractDiabetic retinopathy (DR) is a microvascular complication associated with chronic exposure to hyperglycemia and is a major cause of blindness worldwide. Although clinical assessment and retinal autopsy of diabetic patients provide information on the features and progression of DR, its underlying pathophysiological mechanism cannot be deduced. In order to have a better understanding of the development of DR at the molecular and cellular levels, a variety of animal models have been developed. They include pharmacological induction of hyperglycemia and spontaneous diabetic rodents as well as models of angiogenesis without diabetes (to compensate for the absence of proliferative DR symptoms). In this review, we summarize the existing protocols to induce diabetes using STZ. We also describe and compare the pathological presentations, in both morphological and functional aspects, of the currently available DR animal models. The advantages and disadvantages of using different animals, ranging from zebrafish, rodents to other higher-order mammals, are also discussed. Until now, there is no single model that displays all the clinical features of DR as seen in human. Yet, with the understanding of the pathological findings in these animal models, researchers can select the most suitable models for mechanistic studies or drug screening.
Persistent Identifierhttp://hdl.handle.net/10722/199847
ISSN
2015 Impact Factor: 2.431
2015 SCImago Journal Rankings: 1.024
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, AKWen_US
dc.contributor.authorLo, ACYen_US
dc.date.accessioned2014-07-22T01:42:04Z-
dc.date.available2014-07-22T01:42:04Z-
dc.date.issued2013en_US
dc.identifier.citationJournal of Diabetes Research, 2013, v. 2013, article no.106594, p. 1-29en_US
dc.identifier.issn2314-6745-
dc.identifier.urihttp://hdl.handle.net/10722/199847-
dc.description.abstractDiabetic retinopathy (DR) is a microvascular complication associated with chronic exposure to hyperglycemia and is a major cause of blindness worldwide. Although clinical assessment and retinal autopsy of diabetic patients provide information on the features and progression of DR, its underlying pathophysiological mechanism cannot be deduced. In order to have a better understanding of the development of DR at the molecular and cellular levels, a variety of animal models have been developed. They include pharmacological induction of hyperglycemia and spontaneous diabetic rodents as well as models of angiogenesis without diabetes (to compensate for the absence of proliferative DR symptoms). In this review, we summarize the existing protocols to induce diabetes using STZ. We also describe and compare the pathological presentations, in both morphological and functional aspects, of the currently available DR animal models. The advantages and disadvantages of using different animals, ranging from zebrafish, rodents to other higher-order mammals, are also discussed. Until now, there is no single model that displays all the clinical features of DR as seen in human. Yet, with the understanding of the pathological findings in these animal models, researchers can select the most suitable models for mechanistic studies or drug screening.-
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jdr/-
dc.relation.ispartofJournal of Diabetes Researchen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAnimals-
dc.subject.meshDiabetic Retinopathy - chemically induced - genetics - pathology-
dc.subject.meshDisease Models, Animal-
dc.subject.meshNeovascularization, Pathologic - pathology-
dc.titleAnimal Models of Diabetic Retinopathy: Summary and Comparisonen_US
dc.typeArticleen_US
dc.identifier.emailLo, ACY: amylo@hkucc.hku.hken_US
dc.identifier.authorityLo, ACY=rp00425en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2013/106594en_US
dc.identifier.pmid24286086-
dc.identifier.pmcidPMC3826427-
dc.identifier.hkuros230920en_US
dc.identifier.volume2013, article no.106594en_US
dc.identifier.spage1en_US
dc.identifier.epage29en_US
dc.identifier.isiWOS:000326755800001-
dc.publisher.placeUnited States-

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