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Conference Paper: Impact of graft type on the survival outcome of salvage Liver Transplantation for recurrent Hepatocellular Carcinoma

TitleImpact of graft type on the survival outcome of salvage Liver Transplantation for recurrent Hepatocellular Carcinoma
Authors
Issue Date2014
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021
Citation
The 2014 Joint International Congress of ILTS, ELITA and LICAGE, London, UK., 4-7 June 2014. In Liver Transplantation, 2014, v. 20 suppl. S1, p. S360, abstract no. P-677 How to Cite?
AbstractAim: To evaluate the prognostic influence of graft type on salvage liver transplantation (SLT) for recurrent hepatocellular carcinoma (HCC) Methods: A retrospective analysis of 31 patients who underwent SLT for tumor recurrence after primary surgical treatment for HCC between year 2000-2011 was conducted. All the primary tumors were within USCF criteria. Survival analysis was conducted by Kaplan-Meier methods and compared between groups by log-rank test. P-value < 0.05 was considered significant. Results: A total of 22 patients received living-related SLT (LDSLT) and the remaining 9 patients received cadaveric-related SLT (DDSLT). 10 patients (LDSLT: n=7; DDSLT: n=3) underwent hepatectomy and 21 patients (LDSLT: n=15, DDSLT: n= 6) received radiofrequency ablation as primary treatment for HCC prior to SLT. 11 patients (LDSLT:n=9 vs. DDSLT:n=2, p=0.324) underwent SLT for recurrence beyond the UCSF criteria. 5 patients in each group received TACE as bridging treatment. LDSLT patients were significantly younger (age 53 vs. 58, p=0.046)) and had higher AFP levels (187.1 vs. 30.5ng/ml, p = 0.006) at first diagnosis of HCC than DDSLT patients. There was no significant difference with regard to primary tumor size (2.5 vs. 2.5cm), time to recurrence after primary treatment (15 vs. 8 months), recurrent tumor size (4.0 vs. 4.0cm) and number (n=2 vs. 2), and serum AFP level at recurrence (27.5 vs. 5.0ng/ml) between the two groups. The 1-, 3- and 5-year recurrence-free survival rates for LDSLT were 81.8%, 61.4% and 61.4%; and the corresponding survival rates for DDSLT were all 88.9% (p = 0.176). Conclusion Our study showed that both LDSLT and DDSLT attained satisfactory long-term survival benefit. Although statistically insignificant, DDSLT appeared to have a more favorable oncological outcome than LDSLT. Further studies with larger cohort are warranted to elucidate this issue.
DescriptionPoster Session 3 - Recurrent Disease/Pathology: P-677
This free journal suppl. entitled: The ILTS 20th Annual International Congress
Persistent Identifierhttp://hdl.handle.net/10722/198643
ISSN
2015 Impact Factor: 3.951
2015 SCImago Journal Rankings: 1.763

 

DC FieldValueLanguage
dc.contributor.authorChan, ACY-
dc.contributor.authorChan, SC-
dc.contributor.authorChok, KSH-
dc.contributor.authorCheung, TT-
dc.contributor.authorLo, CM-
dc.date.accessioned2014-07-07T08:29:35Z-
dc.date.available2014-07-07T08:29:35Z-
dc.date.issued2014-
dc.identifier.citationThe 2014 Joint International Congress of ILTS, ELITA and LICAGE, London, UK., 4-7 June 2014. In Liver Transplantation, 2014, v. 20 suppl. S1, p. S360, abstract no. P-677-
dc.identifier.issn1527-6465-
dc.identifier.urihttp://hdl.handle.net/10722/198643-
dc.descriptionPoster Session 3 - Recurrent Disease/Pathology: P-677-
dc.descriptionThis free journal suppl. entitled: The ILTS 20th Annual International Congress-
dc.description.abstractAim: To evaluate the prognostic influence of graft type on salvage liver transplantation (SLT) for recurrent hepatocellular carcinoma (HCC) Methods: A retrospective analysis of 31 patients who underwent SLT for tumor recurrence after primary surgical treatment for HCC between year 2000-2011 was conducted. All the primary tumors were within USCF criteria. Survival analysis was conducted by Kaplan-Meier methods and compared between groups by log-rank test. P-value < 0.05 was considered significant. Results: A total of 22 patients received living-related SLT (LDSLT) and the remaining 9 patients received cadaveric-related SLT (DDSLT). 10 patients (LDSLT: n=7; DDSLT: n=3) underwent hepatectomy and 21 patients (LDSLT: n=15, DDSLT: n= 6) received radiofrequency ablation as primary treatment for HCC prior to SLT. 11 patients (LDSLT:n=9 vs. DDSLT:n=2, p=0.324) underwent SLT for recurrence beyond the UCSF criteria. 5 patients in each group received TACE as bridging treatment. LDSLT patients were significantly younger (age 53 vs. 58, p=0.046)) and had higher AFP levels (187.1 vs. 30.5ng/ml, p = 0.006) at first diagnosis of HCC than DDSLT patients. There was no significant difference with regard to primary tumor size (2.5 vs. 2.5cm), time to recurrence after primary treatment (15 vs. 8 months), recurrent tumor size (4.0 vs. 4.0cm) and number (n=2 vs. 2), and serum AFP level at recurrence (27.5 vs. 5.0ng/ml) between the two groups. The 1-, 3- and 5-year recurrence-free survival rates for LDSLT were 81.8%, 61.4% and 61.4%; and the corresponding survival rates for DDSLT were all 88.9% (p = 0.176). Conclusion Our study showed that both LDSLT and DDSLT attained satisfactory long-term survival benefit. Although statistically insignificant, DDSLT appeared to have a more favorable oncological outcome than LDSLT. Further studies with larger cohort are warranted to elucidate this issue.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021-
dc.relation.ispartofLiver Transplantation-
dc.rightsLiver Transplantation. Copyright © John Wiley & Sons, Inc.-
dc.titleImpact of graft type on the survival outcome of salvage Liver Transplantation for recurrent Hepatocellular Carcinoma-
dc.typeConference_Paper-
dc.identifier.emailChan, ACY: acchan@hku.hk-
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hk-
dc.identifier.emailChok, KSH: chok6275@hku.hk-
dc.identifier.emailCheung, TT: cheung68@hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.authorityChan, ACY=rp00310-
dc.identifier.authorityChan, SC=rp01568-
dc.identifier.authorityChok, KSH=rp02110-
dc.identifier.authorityCheung, TT=rp02129-
dc.identifier.authorityLo, CM=rp00412-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/lt.23901-
dc.identifier.hkuros229865-
dc.identifier.volume20-
dc.identifier.issuesuppl. S1-
dc.identifier.spageS360, abstract no. P-677-
dc.identifier.epageS360, abstract no. P-677-
dc.publisher.placeUnited States-

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