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Article: Purification of Z-Ligustilide by AgNO3-Impregnated Silica Gel

TitlePurification of Z-Ligustilide by AgNO3-Impregnated Silica Gel
硝酸银改性硅胶柱色谱法纯化川芎精油中的藁本内酯
Authors
CHENG, YYANG, CZHAO, JRong, J
Issue Date2014
PublisherChinese Pharmaceutical Association. The Journal's web site is located at http://www.chinjmap.com/ch/index.aspx
Citation
Chinese Journal of Modern Applied Pharmacy, 2014, v. 31 n. 5, p. 552-555 How to Cite?
DOI: http://dx.doi.org/10.13748/j.cnki.issn1007-7693.2014.05.009
中国现代应用药学, 2014, v. 31 n. 5, p. 552-555 How to Cite?
DOI: http://dx.doi.org/10.13748/j.cnki.issn1007-7693.2014.05.009
AbstractOBJECTIVE To investigate the application of AgNO3-impregnated silica gel in a format of column chromatography for the isolation and purification of Z-ligustilide from the essential oil of Ligusticum chuanxiong Hort.. METHODS AgNO3(2%) was impregnated to the common silica gel to generate a new column chromatographic media. The essential oil was eluted with the mobile phase (petroleum ether: acetoacetate=98.5∶1.5), and detected by TLC and UV-Vis spectrometer. The product Z-ligustilide was characterized by GC-MS and HPLC techniques. RESULTS Z-Ligustilide with the purity of 98.87% was effectively purified. CONCLUSION The present study describes a method for rapid isolation of highly pure Z-ligustilide at low cost, allowing future scale-up for modern industrial production.
Persistent Identifierhttp://hdl.handle.net/10722/198262
ISSN
1007-7693

 

DC FieldValueLanguage
dc.contributor.authorCHENG, Yen_US
dc.contributor.authorYANG, Cen_US
dc.contributor.authorZHAO, Jen_US
dc.contributor.authorRong, Jen_US
dc.date.accessioned2014-06-25T02:58:01Z-
dc.date.available2014-06-25T02:58:01Z-
dc.date.issued2014en_US
dc.identifier.citationChinese Journal of Modern Applied Pharmacy, 2014, v. 31 n. 5, p. 552-555en_US
dc.identifier.citation中国现代应用药学, 2014, v. 31 n. 5, p. 552-555en_US
dc.identifier.issn1007-7693-
dc.identifier.urihttp://hdl.handle.net/10722/198262-
dc.description.abstractOBJECTIVE To investigate the application of AgNO3-impregnated silica gel in a format of column chromatography for the isolation and purification of Z-ligustilide from the essential oil of Ligusticum chuanxiong Hort.. METHODS AgNO3(2%) was impregnated to the common silica gel to generate a new column chromatographic media. The essential oil was eluted with the mobile phase (petroleum ether: acetoacetate=98.5∶1.5), and detected by TLC and UV-Vis spectrometer. The product Z-ligustilide was characterized by GC-MS and HPLC techniques. RESULTS Z-Ligustilide with the purity of 98.87% was effectively purified. CONCLUSION The present study describes a method for rapid isolation of highly pure Z-ligustilide at low cost, allowing future scale-up for modern industrial production.en_US
dc.languagechien_US
dc.publisherChinese Pharmaceutical Association. The Journal's web site is located at http://www.chinjmap.com/ch/index.aspx-
dc.relation.ispartofChinese Journal of Modern Applied Pharmacyen_US
dc.relation.ispartof中国现代应用药学en_US
dc.titlePurification of Z-Ligustilide by AgNO3-Impregnated Silica Gelen_US
dc.title硝酸银改性硅胶柱色谱法纯化川芎精油中的藁本内酯en_US
dc.typeArticleen_US
dc.identifier.emailRong, J: jrong@hku.hken_US
dc.identifier.authorityRong, J=rp00515en_US
dc.identifier.doi10.13748/j.cnki.issn1007-7693.2014.05.009en_US
dc.identifier.hkuros229446en_US
dc.identifier.volume31en_US
dc.identifier.issue5en_US
dc.identifier.spage552en_US
dc.identifier.epage555en_US
dc.identifier.issnl1007-7693-

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