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Conference Paper: Dendrimer encapsulation enhances anti-inflammatory efficacy of silver nanoparticles in burn wound

TitleDendrimer encapsulation enhances anti-inflammatory efficacy of silver nanoparticles in burn wound
Authors
Issue Date2014
Citation
The 47th Annual Scientific Meeting of the Pacific Association of Pediatric Surgeons (PAPS 2014), Banff, AB., Canada, 25-29 May 2014. How to Cite?
AbstractBACKGROUND/PURPOSE: Our previous studies revealed that silver nanoparticles (AgNPs) promoted wound healing in part through their anti-inflammatory actions. As recent reports also suggested anti-inflammatory effects of dendrimers, we therefore undertook this study using dendrimers as the delivery system for AgNP to explore any potential synergistic anti-inflammatory efficacy. METHODS: Lipopolysaccharide (LPS) was added to cultured RAW264.7 and J774.1 cells to mimic in vitro inflammation condition, followed by the addition of either silver dendrimer nanocomposite (Ag-DNC), AgNPs or derdrimer. The levels of inflammatory markers TNF-alpha and interleukin-6 were assessed using ELISA assay. Furthermore, in vivo effects such of Ag-DNC, AgNPs or dendrimer were studied in a burn wound model in mice. RESULTS: Our results confirmed that although both naked dendrimer and AgNPs had anti-inflammatory properties, Ag-DNC was shown to have the best anti-inflammatory efficacy than AgNPs or dendrimer alone in in-vitro studies. In-vivo experiments also indicated that animals in the Ag-DNC group had the fastest healing time with the least inflammation. CONCLUSIONS: Our study would suggest that dendrimer could provide additional anti-inflammatory benefits and might be an excellent delivery system for silver nanoparticles for future clinical application.
DescriptionOral Presentations - Basic Science (BS): no. BS13
Persistent Identifierhttp://hdl.handle.net/10722/198208

 

DC FieldValueLanguage
dc.contributor.authorLiu, Xen_US
dc.contributor.authorLok, CNen_US
dc.contributor.authorZhang, Ren_US
dc.contributor.authorWong, KKYen_US
dc.date.accessioned2014-06-25T02:54:47Z-
dc.date.available2014-06-25T02:54:47Z-
dc.date.issued2014en_US
dc.identifier.citationThe 47th Annual Scientific Meeting of the Pacific Association of Pediatric Surgeons (PAPS 2014), Banff, AB., Canada, 25-29 May 2014.en_US
dc.identifier.urihttp://hdl.handle.net/10722/198208-
dc.descriptionOral Presentations - Basic Science (BS): no. BS13-
dc.description.abstractBACKGROUND/PURPOSE: Our previous studies revealed that silver nanoparticles (AgNPs) promoted wound healing in part through their anti-inflammatory actions. As recent reports also suggested anti-inflammatory effects of dendrimers, we therefore undertook this study using dendrimers as the delivery system for AgNP to explore any potential synergistic anti-inflammatory efficacy. METHODS: Lipopolysaccharide (LPS) was added to cultured RAW264.7 and J774.1 cells to mimic in vitro inflammation condition, followed by the addition of either silver dendrimer nanocomposite (Ag-DNC), AgNPs or derdrimer. The levels of inflammatory markers TNF-alpha and interleukin-6 were assessed using ELISA assay. Furthermore, in vivo effects such of Ag-DNC, AgNPs or dendrimer were studied in a burn wound model in mice. RESULTS: Our results confirmed that although both naked dendrimer and AgNPs had anti-inflammatory properties, Ag-DNC was shown to have the best anti-inflammatory efficacy than AgNPs or dendrimer alone in in-vitro studies. In-vivo experiments also indicated that animals in the Ag-DNC group had the fastest healing time with the least inflammation. CONCLUSIONS: Our study would suggest that dendrimer could provide additional anti-inflammatory benefits and might be an excellent delivery system for silver nanoparticles for future clinical application.-
dc.languageengen_US
dc.relation.ispartof47th PAPS Annual Scientific Meeting 2014en_US
dc.titleDendrimer encapsulation enhances anti-inflammatory efficacy of silver nanoparticles in burn wounden_US
dc.typeConference_Paperen_US
dc.identifier.emailLiu, X: liuxl@hkucc.hku.hken_US
dc.identifier.emailWong, KKY: kkywong@hku.hken_US
dc.identifier.authorityWong, KKY=rp01392en_US
dc.identifier.hkuros229591en_US

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