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Conference Paper: Association of GABRG2 rs211037 polymorphism with susceptibility to epilepsy in Asians: a multicentre cohort study and meta-analysis

TitleAssociation of GABRG2 rs211037 polymorphism with susceptibility to epilepsy in Asians: a multicentre cohort study and meta-analysis
Authors
Issue Date2014
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
The 2014 Annual Meeting of Experimental Biology (EB 2014), San Diego, California, USA, 26-30 April 2014. In The FASEB Journal, 2014, v. 28 n. Suppl. 1, p. abstract no. 912.8 How to Cite?
AbstractPURPOSE:The gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2) gene encodes GABR-gamma2 protein, which has been implicated in susceptibility to epilepsy. Several studies have investigated whether the synonymous GABRG2 rs211037 polymorphism is a risk factor for various epilepsy types including febrile seizure (FS), idiopathic generalized epilepsy (IGE) and symptomatic epilepsy (SE), however results have been inconclusive. Therefore, we examined association of this polymorphism in FS, IGE, SE, and cryptogenic epilepsy (CE), through both a multicenter case control study and a meta-analysis. METHODS: The rs211037 was genotyped in Hong Kong Chinese and in Malaysian Chinese, Indian, and Malay participants. Genotypes of 5101 participants, of which 1769 were from Malaysia and 3332 from Hong Kong, were included in this case-control study. KEY FINDINGS:Of the 1179 patients, 66%, 13%, and 21% were Chinese, Indians, and Malays, respectively. Of the Chinese patients, 37% were from Malaysia and 63% were from Hong Kong. Significant association was observed between rs211037 polymorphism and susceptibility to SE (T vs. Cp=0.000003 and TT vs. CC, p=0.00001) or to epilepsy with FS (T vs. C p=0.02 and CT vs. CC, p=0.02) in overall Chinese and to IGE in Chinese from Malaysia (TT vs. CC, p=0.01), but not to CE. Meta-analysis revealed a strong association between rs211037 with FS and SE in Asians for alleles (p=0.02, p=0.002 and p<0.00001, respectively) and for all genotype models. SIGNIFICANCE: Our data suggests that GABRG2 rs211037 polymorphism is a risk factor for susceptibility to SE and FS in Asians, particularly in Chinese.
DescriptionConference theme: Transforming the Future through Science
Poster session: Physiology: Genetics, Genomics and Proteomics
Persistent Identifierhttp://hdl.handle.net/10722/198195
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorHaerian, BSen_US
dc.contributor.authorBaum, Len_US
dc.contributor.authorKwan, Pen_US
dc.contributor.authorCherny, SSen_US
dc.contributor.authorTan, HJen_US
dc.contributor.authorRaymond, AAen_US
dc.contributor.authorMohamed, Zen_US
dc.date.accessioned2014-06-25T02:53:35Z-
dc.date.available2014-06-25T02:53:35Z-
dc.date.issued2014en_US
dc.identifier.citationThe 2014 Annual Meeting of Experimental Biology (EB 2014), San Diego, California, USA, 26-30 April 2014. In The FASEB Journal, 2014, v. 28 n. Suppl. 1, p. abstract no. 912.8en_US
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/198195-
dc.descriptionConference theme: Transforming the Future through Science-
dc.descriptionPoster session: Physiology: Genetics, Genomics and Proteomics-
dc.description.abstractPURPOSE:The gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2) gene encodes GABR-gamma2 protein, which has been implicated in susceptibility to epilepsy. Several studies have investigated whether the synonymous GABRG2 rs211037 polymorphism is a risk factor for various epilepsy types including febrile seizure (FS), idiopathic generalized epilepsy (IGE) and symptomatic epilepsy (SE), however results have been inconclusive. Therefore, we examined association of this polymorphism in FS, IGE, SE, and cryptogenic epilepsy (CE), through both a multicenter case control study and a meta-analysis. METHODS: The rs211037 was genotyped in Hong Kong Chinese and in Malaysian Chinese, Indian, and Malay participants. Genotypes of 5101 participants, of which 1769 were from Malaysia and 3332 from Hong Kong, were included in this case-control study. KEY FINDINGS:Of the 1179 patients, 66%, 13%, and 21% were Chinese, Indians, and Malays, respectively. Of the Chinese patients, 37% were from Malaysia and 63% were from Hong Kong. Significant association was observed between rs211037 polymorphism and susceptibility to SE (T vs. Cp=0.000003 and TT vs. CC, p=0.00001) or to epilepsy with FS (T vs. C p=0.02 and CT vs. CC, p=0.02) in overall Chinese and to IGE in Chinese from Malaysia (TT vs. CC, p=0.01), but not to CE. Meta-analysis revealed a strong association between rs211037 with FS and SE in Asians for alleles (p=0.02, p=0.002 and p<0.00001, respectively) and for all genotype models. SIGNIFICANCE: Our data suggests that GABRG2 rs211037 polymorphism is a risk factor for susceptibility to SE and FS in Asians, particularly in Chinese.-
dc.languageengen_US
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/-
dc.relation.ispartofThe FASEB Journalen_US
dc.titleAssociation of GABRG2 rs211037 polymorphism with susceptibility to epilepsy in Asians: a multicentre cohort study and meta-analysisen_US
dc.typeConference_Paperen_US
dc.identifier.emailCherny, SS: cherny@hku.hken_US
dc.identifier.authorityCherny, SS=rp00232en_US
dc.identifier.hkuros229336en_US
dc.identifier.volume28en_US
dc.identifier.issueSuppl. 1en_US
dc.identifier.spageabstract no. 912.8-
dc.identifier.epageabstract no. 912.8-
dc.publisher.placeUnited States-

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