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Article: High Prevalence of Non-Alcoholic Fatty Liver Disease in the Chinese - Results from the Hong Kong Liver Health Census

TitleHigh Prevalence of Non-Alcoholic Fatty Liver Disease in the Chinese - Results from the Hong Kong Liver Health Census
Authors
Issue Date2014
Citation
Liver Int, 2014 How to Cite?
AbstractBACKGROUND: The prevalence of NAFLD in the general Chinese population is not clear, as there have been few large population studies focussing on healthy individuals AIM: To determine the prevalence and risk factors of non-alcoholic fatty liver disease (NAFLD) in a healthy Westernized Chinese population. METHODS: This is a prospective cross sectional study of 2,493 volunteers recruited from the general population and the Red Cross Transfusion Center in Hong Kong. All underwent comprehensive questionnaire survey, blood test, abdominal ultrasound and transient elastography. RESULTS: The prevalence of NAFLD was 42%. Gender, age, waist circumference, systolic blood pressure, fasting cholesterol and glucose levels were significant factors. The relative risk of NAFLD in those with high waist circumference, diabetes, hypertension, and hypercholesterolemia was 2.99, 2.01, 1.79, and 1.54 respectively. The degree of steatosis increased with levels of fasting glucose, cholesterol, systolic blood pressure and waist circumference (all p<0.001). The optimal waist circumference was found to be 84 and 74cm for male and females respectively, with a relative risk of 5.16 for those above this limit. 1.2% and 0.002% of subjects with NAFLD had advanced liver fibrosis and cirrhosis respectively. CONCLUSION: NAFLD was found to be highly prevalent in the Chinese population. Increasing levels of risk factors were associated with increasing severity of NAFLD. Lower cut-off levels of waist circumference to predict NAFLD should be adopted for Chinese population. This article is protected by copyright. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/198047
ISSN
2015 Impact Factor: 4.47
2015 SCImago Journal Rankings: 1.677

 

DC FieldValueLanguage
dc.contributor.authorFung, JYYen_US
dc.contributor.authorLee, CKen_US
dc.contributor.authorChan, Men_US
dc.contributor.authorSeto, WKWen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorYuen, RMFen_US
dc.date.accessioned2014-06-25T02:42:08Z-
dc.date.available2014-06-25T02:42:08Z-
dc.date.issued2014en_US
dc.identifier.citationLiver Int, 2014en_US
dc.identifier.issn1478-3223en_US
dc.identifier.urihttp://hdl.handle.net/10722/198047-
dc.description.abstractBACKGROUND: The prevalence of NAFLD in the general Chinese population is not clear, as there have been few large population studies focussing on healthy individuals AIM: To determine the prevalence and risk factors of non-alcoholic fatty liver disease (NAFLD) in a healthy Westernized Chinese population. METHODS: This is a prospective cross sectional study of 2,493 volunteers recruited from the general population and the Red Cross Transfusion Center in Hong Kong. All underwent comprehensive questionnaire survey, blood test, abdominal ultrasound and transient elastography. RESULTS: The prevalence of NAFLD was 42%. Gender, age, waist circumference, systolic blood pressure, fasting cholesterol and glucose levels were significant factors. The relative risk of NAFLD in those with high waist circumference, diabetes, hypertension, and hypercholesterolemia was 2.99, 2.01, 1.79, and 1.54 respectively. The degree of steatosis increased with levels of fasting glucose, cholesterol, systolic blood pressure and waist circumference (all p<0.001). The optimal waist circumference was found to be 84 and 74cm for male and females respectively, with a relative risk of 5.16 for those above this limit. 1.2% and 0.002% of subjects with NAFLD had advanced liver fibrosis and cirrhosis respectively. CONCLUSION: NAFLD was found to be highly prevalent in the Chinese population. Increasing levels of risk factors were associated with increasing severity of NAFLD. Lower cut-off levels of waist circumference to predict NAFLD should be adopted for Chinese population. This article is protected by copyright. All rights reserved.en_US
dc.languageengen_US
dc.relation.ispartofLiver Inten_US
dc.titleHigh Prevalence of Non-Alcoholic Fatty Liver Disease in the Chinese - Results from the Hong Kong Liver Health Censusen_US
dc.typeArticleen_US
dc.identifier.emailFung, JYY: jfung@hkucc.hku.hken_US
dc.identifier.emailSeto, WKW: wkseto2@hku.hken_US
dc.identifier.emailLai, CL: hrmelcl@hku.hken_US
dc.identifier.emailYuen, RMF: mfyuen@hku.hken_US
dc.identifier.authorityFung, JYY=rp00518en_US
dc.identifier.authoritySeto, WKW=rp01659en_US
dc.identifier.authorityYuen, RMF=rp00479en_US
dc.identifier.doi10.1111/liv.12619en_US
dc.identifier.hkuros229435en_US

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