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Article: Hepatitis B surface antigen levels after hepatitis B e-antigen seroclearance: a longitudinal follow-up study

TitleHepatitis B surface antigen levels after hepatitis B e-antigen seroclearance: a longitudinal follow-up study
Authors
Issue Date2015
Citation
Liver International, 2015, v. 35 n. 3, p. 854-859 How to Cite?
AbstractBACKGROUND & AIMS: The role of quantitative hepatitis B surface antigen (HBsAg) after hepatitis B e-antigen (HBeAg) seroclearance is not well defined. To determine the role of HBsAg levels in predicting significant viremia and hepatitis flares after HBeAg seroclearance. METHODS: A total of 228 chronic hepatitis B patients with spontaneous HBeAg seroclearance were included. Patients were followed up regularly at 3-6 monthly intervals with routine liver biochemistry and hepatitis B serology. Levels of HBV DNA and HBsAg were measured at yearly intervals for up to 5 years after HBeAg seroclearance. RESULTS: The median log HBsAg and HBV DNA level after HBeAg seroclearance was 3.52 IU/ml and 4.13 IU/ ml respectively, with no significant correlation observed between them (P = 0.572). The HBV DNA at HBeAg seroclearance was 4.13 log IU/ml, compared with 3.12 log IU/ml after 5 years (P < 0.001). No significant change was observed for HBsAg levels (P = 0.991). Hepatitis B flares occurred in 76 (33.3%) patients. Patients who developed hepatitic flares compared with those without hepatitic flares were older (40 vs. 36 years, P = 0.001), had a higher HBV DNA at the time of HBeAg seroclearance (4.70 vs. 3.77 log IU/ml, P =< 0.001), and more likely to be males (42.7% vs. 23.4%, P = 0.002) respectively. There was no difference in HBsAg levels between those with and without hepatitis flare (3.54 vs. 3.52 log IU/ml respectively, P = 0.555). CONCLUSION: HBV DNA levels, but not HBsAg levels, after HBeAg seroclearance were associated with subsequent significant viremia and hepatitic flares. Male gender and older age was associated with significant viremia.
Persistent Identifierhttp://hdl.handle.net/10722/198046
ISSN
2015 Impact Factor: 4.47
2015 SCImago Journal Rankings: 1.677

 

DC FieldValueLanguage
dc.contributor.authorFung, JYYen_US
dc.contributor.authorSeto, WKWen_US
dc.contributor.authorWong, DKHen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorYuen, RMFen_US
dc.date.accessioned2014-06-25T02:42:08Z-
dc.date.available2014-06-25T02:42:08Z-
dc.date.issued2015en_US
dc.identifier.citationLiver International, 2015, v. 35 n. 3, p. 854-859en_US
dc.identifier.issn1478-3223en_US
dc.identifier.urihttp://hdl.handle.net/10722/198046-
dc.description.abstractBACKGROUND & AIMS: The role of quantitative hepatitis B surface antigen (HBsAg) after hepatitis B e-antigen (HBeAg) seroclearance is not well defined. To determine the role of HBsAg levels in predicting significant viremia and hepatitis flares after HBeAg seroclearance. METHODS: A total of 228 chronic hepatitis B patients with spontaneous HBeAg seroclearance were included. Patients were followed up regularly at 3-6 monthly intervals with routine liver biochemistry and hepatitis B serology. Levels of HBV DNA and HBsAg were measured at yearly intervals for up to 5 years after HBeAg seroclearance. RESULTS: The median log HBsAg and HBV DNA level after HBeAg seroclearance was 3.52 IU/ml and 4.13 IU/ ml respectively, with no significant correlation observed between them (P = 0.572). The HBV DNA at HBeAg seroclearance was 4.13 log IU/ml, compared with 3.12 log IU/ml after 5 years (P < 0.001). No significant change was observed for HBsAg levels (P = 0.991). Hepatitis B flares occurred in 76 (33.3%) patients. Patients who developed hepatitic flares compared with those without hepatitic flares were older (40 vs. 36 years, P = 0.001), had a higher HBV DNA at the time of HBeAg seroclearance (4.70 vs. 3.77 log IU/ml, P =< 0.001), and more likely to be males (42.7% vs. 23.4%, P = 0.002) respectively. There was no difference in HBsAg levels between those with and without hepatitis flare (3.54 vs. 3.52 log IU/ml respectively, P = 0.555). CONCLUSION: HBV DNA levels, but not HBsAg levels, after HBeAg seroclearance were associated with subsequent significant viremia and hepatitic flares. Male gender and older age was associated with significant viremia.en_US
dc.languageengen_US
dc.relation.ispartofLiver Internationalen_US
dc.titleHepatitis B surface antigen levels after hepatitis B e-antigen seroclearance: a longitudinal follow-up studyen_US
dc.typeArticleen_US
dc.identifier.emailFung, JYY: jfung@hkucc.hku.hken_US
dc.identifier.emailSeto, WKW: wkseto2@hku.hken_US
dc.identifier.emailWong, DKH: danywong@hku.hken_US
dc.identifier.emailLai, CL: hrmelcl@hku.hken_US
dc.identifier.emailYuen, RMF: mfyuen@hku.hken_US
dc.identifier.authorityFung, JYY=rp00518en_US
dc.identifier.authoritySeto, WKW=rp01659en_US
dc.identifier.authorityWong, DKH=rp00492en_US
dc.identifier.authorityYuen, RMF=rp00479en_US
dc.identifier.doi10.1111/liv.12596en_US
dc.identifier.hkuros229434en_US

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