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Article: Effect of Hepatitis B Virus Reverse Transcriptase Variations on Entecavir Treatment Response

TitleEffect of Hepatitis B Virus Reverse Transcriptase Variations on Entecavir Treatment Response
Authors
Issue Date2014
Citation
J Infect Dis, 2014, v. 210 n. 5, p. 701-707 How to Cite?
AbstractBackground. Entecavir therapy often reduces hepatitis B virus (HBV) DNA to an undetectable level, but HBV DNA remain detectable in some patients. We investigated whether baseline HBV reverse transcriptase (rt) polymorphism and quasispecies complexity and diversity were associated with treatment response.Methods. Pretreatment HBV DNA levels, HBV rt sequence, serology, and quasispecies complexity and diversity from 305 entecavir-treated patients were determined. These data were tested for their association with year 1 virological outcome, defined by optimal response (undetectable HBV DNA; lower limit of detection,
Persistent Identifierhttp://hdl.handle.net/10722/198044
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000

 

DC FieldValueLanguage
dc.contributor.authorWong, DKHen_US
dc.contributor.authorKopaniszen, Men_US
dc.contributor.authorOmagari, Ken_US
dc.contributor.authorTanaka, Yen_US
dc.contributor.authorFong, DYTen_US
dc.contributor.authorSeto, WKWen_US
dc.contributor.authorFung, JYYen_US
dc.contributor.authorHuang, FYen_US
dc.contributor.authorZhang, AYen_US
dc.contributor.authorHung, IFNen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorYuen, RMFen_US
dc.date.accessioned2014-06-25T02:42:07Z-
dc.date.available2014-06-25T02:42:07Z-
dc.date.issued2014en_US
dc.identifier.citationJ Infect Dis, 2014, v. 210 n. 5, p. 701-707en_US
dc.identifier.issn0022-1899en_US
dc.identifier.urihttp://hdl.handle.net/10722/198044-
dc.description.abstractBackground. Entecavir therapy often reduces hepatitis B virus (HBV) DNA to an undetectable level, but HBV DNA remain detectable in some patients. We investigated whether baseline HBV reverse transcriptase (rt) polymorphism and quasispecies complexity and diversity were associated with treatment response.Methods. Pretreatment HBV DNA levels, HBV rt sequence, serology, and quasispecies complexity and diversity from 305 entecavir-treated patients were determined. These data were tested for their association with year 1 virological outcome, defined by optimal response (undetectable HBV DNA; lower limit of detection, </=12 IU/mL) or partial response (detectable HBV DNA).Results. Four rt variants were more frequently detected in the 64 partial responders than in the 241 optimal responders (all P < .05). Multivariate analysis revealed that high baseline HBV DNA level (P < .0001; odds ratio [OR], 2.32), HBV e antigen (HBeAg) positivity (P < .001; OR, 3.70), and rt124N (P = .002; OR, 3.06) were associated with a partial entecavir response. Compared with the optimal responders, the partial responders had a lower quasispecies complexity and diversity.Conclusions. Apart from the known factors (high baseline HBV DNA level and HBeAg positivity), a novel single nucleotide polymorphism (rt124N) and lower quasispecies complexity and diversity were associated with partial entecavir response at year 1.en_US
dc.languageengen_US
dc.relation.ispartofJ Infect Disen_US
dc.titleEffect of Hepatitis B Virus Reverse Transcriptase Variations on Entecavir Treatment Responseen_US
dc.typeArticleen_US
dc.identifier.emailWong, DKH: danywong@hku.hken_US
dc.identifier.emailFong, DYT: dytfong@hku.hken_US
dc.identifier.emailSeto, WKW: wkseto2@hku.hken_US
dc.identifier.emailFung, JYY: jfung@hkucc.hku.hken_US
dc.identifier.emailHuang, FY: camy@graduate.hku.hken_US
dc.identifier.emailHung, IFN: ivanhung@hkucc.hku.hken_US
dc.identifier.emailLai, CL: hrmelcl@hku.hken_US
dc.identifier.emailYuen, RMF: mfyuen@hku.hken_US
dc.identifier.authorityWong, DKH=rp00492en_US
dc.identifier.authorityFong, DYT=rp00253en_US
dc.identifier.authoritySeto, WKW=rp01659en_US
dc.identifier.authorityFung, JYY=rp00518en_US
dc.identifier.authorityHung, IFN=rp00508en_US
dc.identifier.authorityYuen, RMF=rp00479en_US
dc.identifier.doi10.1093/infdis/jiu133en_US
dc.identifier.hkuros229432en_US

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