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Article: Encapsulation of semiconducting polymers in vault protein cages

TitleEncapsulation of semiconducting polymers in vault protein cages
Authors
Issue Date2008
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/nanolett
Citation
Nano Letters, 2008, v. 8 n. 10, p. 3503-3509 How to Cite?
AbstractWe demonstrate that a semiconducting polymer [poly(2-methoxy-5-propyloxy sulfonate phenylene vinylene), MPS-PPV] can be encapsulated inside recombinant, self-assembling protein nanocapsules called 'vaults'. Polymer incorporation into these nanosized protein cages, found naturally at approximately 10,000 copies per human cell, was confirmed by fluorescence spectroscopy and small-angle X-ray scattering. Although vault cellular functions and gating mechanisms remain unknown, their large internal volume and natural prevalence within the human body suggests they could be used as carriers for therapeutics and medical imaging reagents. This study provides the groundwork for the use of vaults in encapsulation and delivery applications.
Persistent Identifierhttp://hdl.handle.net/10722/197920
ISSN
2015 Impact Factor: 13.779
2015 SCImago Journal Rankings: 9.006
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNg, BC-
dc.contributor.authorYu, M-
dc.contributor.authorGopal, A-
dc.contributor.authorRome, LH-
dc.contributor.authorMonbouquette, HG-
dc.contributor.authorTolbert, SH-
dc.date.accessioned2014-06-11T07:51:25Z-
dc.date.available2014-06-11T07:51:25Z-
dc.date.issued2008-
dc.identifier.citationNano Letters, 2008, v. 8 n. 10, p. 3503-3509-
dc.identifier.issn1530-6984-
dc.identifier.urihttp://hdl.handle.net/10722/197920-
dc.description.abstractWe demonstrate that a semiconducting polymer [poly(2-methoxy-5-propyloxy sulfonate phenylene vinylene), MPS-PPV] can be encapsulated inside recombinant, self-assembling protein nanocapsules called 'vaults'. Polymer incorporation into these nanosized protein cages, found naturally at approximately 10,000 copies per human cell, was confirmed by fluorescence spectroscopy and small-angle X-ray scattering. Although vault cellular functions and gating mechanisms remain unknown, their large internal volume and natural prevalence within the human body suggests they could be used as carriers for therapeutics and medical imaging reagents. This study provides the groundwork for the use of vaults in encapsulation and delivery applications.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/nanolett-
dc.relation.ispartofNano Letters-
dc.subject.meshDNA - chemistry-
dc.subject.meshDrug Carriers-
dc.subject.meshGene Therapy - methods-
dc.subject.meshNanocapsules - chemistry-
dc.subject.meshSemiconductors-
dc.titleEncapsulation of semiconducting polymers in vault protein cagesen_US
dc.typeArticleen_US
dc.identifier.emailNg, BC: ngbenny@hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1021/nl080537r-
dc.identifier.pmid18803422-
dc.identifier.pmcidPMC3046045-
dc.identifier.scopuseid_2-s2.0-56149096450-
dc.identifier.hkuros202530-
dc.identifier.volume8-
dc.identifier.issue10-
dc.identifier.spage3503-
dc.identifier.epage3509-
dc.identifier.isiWOS:000259906800078-
dc.publisher.placeUnited States-

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