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Conference Paper: Reduced cardiopulmonary fitness in childhood acute lymphoblastic leukemia survivors

TitleReduced cardiopulmonary fitness in childhood acute lymphoblastic leukemia survivors
Authors
KeywordsMedical sciences
Oncology medical sciences
Pediatrics
Issue Date2013
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1545-5017/
Citation
The 45th Congress of the International Society of Paediatric Oncology (SIOP 2013), Hong Kong, China, 25-28 September 2013. In Pediatric Blood & Cancer, 2013, v. 60 S3, p. 165, abstract no. P-0478 How to Cite?
AbstractPURPOSE/OBJECTIVE: One in 600 adult individuals in USA is a survivor of childhood cancers. A number of chemotherapeutic agents are associated with long-term cardiopulmonary toxicities. Low cardiopulmonary fitness is a strong predictor of all-cause mortality, cardiovascular disease and functional limitations. The purpose of this study was to evaluate cardiopulmonary fitness in Chinese paediatric acute lymphoblastic leukemia (ALL) survivors and to identify high risk group for early behavioral modification. MATERIALS AND METHODS: Childhood ALL survivors were recruited. Cardiopulmonary fitness expressed as peak oxygen consumption (peak VO2) was measured. Exercise response of ALL survivors was compared to a group of age, gender and BMI matched healthy controls. Maximal effort was defined as a respiratory exchange ratio (RER) > 1.10 with clear signs of exhaustion RESULTS: Fifty-one survivors (27 males, 24 females) with a mean age of 18.3 +/- 4.5 years were included in the analysis. Peak VO2 was significantly reduced in survivors compared with controls (35.2 +/- 9.8 vs 39.9 +/- 11.9 mL x Kg -1 x min -1 respectively, p < 0.05). Survivors also had significantly lower peak heart rate (HR) (186 +/- 9 vs 192 +/- 11 bpm, p < 0.05) and greater heart rate reserve (HRR) (5.3 +/- 9.8 vs -0.9 +/- 11.5 bpm, p < 0.05) than controls. Sixty-seven percent of survivors (15 males, 19 females) failed to achieve a peak HR greater than 95% of predicted maximal HR, compared to 41% in the control group (p < 0.05). The mean duration from assessment and termination of treatment for survivors with suboptimal peak HR (n = 34) vs those who could achieved optimal peak HR (n = 17) was 8.9 +/- 3.5 and 12.2 +/- 4.7 years respectively (p < 0.05). ALL risk stratifications in these 2 groups were similar. CONCLUSIONS: Significant proportion of ALL long-term survivors had reduced cardiopulmonary fitness which was a negative risk factor or subsequent cardiovascular risk. Early behavioral modifications are probably justified in this group of patients.
DescriptionThis journal suppl. entitled: Supplement: SIOP Abstratcs: 45th Congress of the International Society of Paediatric Oncology (SIOP) ... 2013
Poster Session - Late Effects: abstract no. P-0478
Persistent Identifierhttp://hdl.handle.net/10722/197712
ISSN
2015 Impact Factor: 2.634
2015 SCImago Journal Rankings: 1.505

 

DC FieldValueLanguage
dc.contributor.authorCheng, FWTen_US
dc.contributor.authorYu, CCWen_US
dc.contributor.authorCheuk, DKLen_US
dc.contributor.authorLi, CHen_US
dc.contributor.authorChu, YYLen_US
dc.contributor.authorSo, HKen_US
dc.contributor.authorYau, JPWen_US
dc.contributor.authorLing, SCen_US
dc.contributor.authorChan, GCFen_US
dc.contributor.authorLi, AMen_US
dc.contributor.authorLi, CKen_US
dc.date.accessioned2014-05-29T08:45:05Z-
dc.date.available2014-05-29T08:45:05Z-
dc.date.issued2013en_US
dc.identifier.citationThe 45th Congress of the International Society of Paediatric Oncology (SIOP 2013), Hong Kong, China, 25-28 September 2013. In Pediatric Blood & Cancer, 2013, v. 60 S3, p. 165, abstract no. P-0478en_US
dc.identifier.issn1545-5009-
dc.identifier.urihttp://hdl.handle.net/10722/197712-
dc.descriptionThis journal suppl. entitled: Supplement: SIOP Abstratcs: 45th Congress of the International Society of Paediatric Oncology (SIOP) ... 2013-
dc.descriptionPoster Session - Late Effects: abstract no. P-0478-
dc.description.abstractPURPOSE/OBJECTIVE: One in 600 adult individuals in USA is a survivor of childhood cancers. A number of chemotherapeutic agents are associated with long-term cardiopulmonary toxicities. Low cardiopulmonary fitness is a strong predictor of all-cause mortality, cardiovascular disease and functional limitations. The purpose of this study was to evaluate cardiopulmonary fitness in Chinese paediatric acute lymphoblastic leukemia (ALL) survivors and to identify high risk group for early behavioral modification. MATERIALS AND METHODS: Childhood ALL survivors were recruited. Cardiopulmonary fitness expressed as peak oxygen consumption (peak VO2) was measured. Exercise response of ALL survivors was compared to a group of age, gender and BMI matched healthy controls. Maximal effort was defined as a respiratory exchange ratio (RER) > 1.10 with clear signs of exhaustion RESULTS: Fifty-one survivors (27 males, 24 females) with a mean age of 18.3 +/- 4.5 years were included in the analysis. Peak VO2 was significantly reduced in survivors compared with controls (35.2 +/- 9.8 vs 39.9 +/- 11.9 mL x Kg -1 x min -1 respectively, p < 0.05). Survivors also had significantly lower peak heart rate (HR) (186 +/- 9 vs 192 +/- 11 bpm, p < 0.05) and greater heart rate reserve (HRR) (5.3 +/- 9.8 vs -0.9 +/- 11.5 bpm, p < 0.05) than controls. Sixty-seven percent of survivors (15 males, 19 females) failed to achieve a peak HR greater than 95% of predicted maximal HR, compared to 41% in the control group (p < 0.05). The mean duration from assessment and termination of treatment for survivors with suboptimal peak HR (n = 34) vs those who could achieved optimal peak HR (n = 17) was 8.9 +/- 3.5 and 12.2 +/- 4.7 years respectively (p < 0.05). ALL risk stratifications in these 2 groups were similar. CONCLUSIONS: Significant proportion of ALL long-term survivors had reduced cardiopulmonary fitness which was a negative risk factor or subsequent cardiovascular risk. Early behavioral modifications are probably justified in this group of patients.-
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1545-5017/-
dc.relation.ispartofPediatric Blood & Canceren_US
dc.rightsPediatric Blood & Cancer. Copyright © John Wiley & Sons, Inc.-
dc.subjectMedical sciences-
dc.subjectOncology medical sciences-
dc.subjectPediatrics-
dc.titleReduced cardiopulmonary fitness in childhood acute lymphoblastic leukemia survivorsen_US
dc.typeConference_Paperen_US
dc.identifier.emailCheuk, DKL: klcheuk@hkucc.hku.hken_US
dc.identifier.emailChan, GCF: gcfchan@hku.hken_US
dc.identifier.emailLi, CK: lichik@hkucc.hku.hk-
dc.identifier.authorityChan, GCF=rp00431en_US
dc.identifier.doi10.1002/pbc.24719-
dc.identifier.hkuros229021en_US
dc.identifier.volume60-
dc.identifier.issueS3-
dc.identifier.spage165-
dc.identifier.epage165-
dc.publisher.placeUnited States-

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