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Conference Paper: Prevalence And Predictors Of Depressive Symptoms In Non-Affective Psychosis Patients In Jockey Club Early Psychosis (Jcep) Project In Hong Kong

TitlePrevalence And Predictors Of Depressive Symptoms In Non-Affective Psychosis Patients In Jockey Club Early Psychosis (Jcep) Project In Hong Kong
Authors
Issue Date2014
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 4th Biennial Schizophrenia International Research Conference, Florence, Italy, 5-9 April 2014. In Schizophrenia Research, 2014, v. 153 suppl. 1, p. S267, poster no. M213 How to Cite?
AbstractBACKGROUND: Depressive symptoms are frequently found in the early stage of psychotic disorders and are associated with heightened risk of suicide. In this study, we aimed to examine the prevalence and factors predictive of the occurrence of depressive symptoms in adult patients presenting with first-episode non-affective psychosis to JCEP project in Hong Kong. METHODS: A total of 343 patients aged 26 to 55 years presenting with first-episode non-affective psychosis (DSM-IV schizophrenia, schizophreniform disorder, delusional disorder, brief psychotic disorder or psychosis NOS) to Jockey Club Early Psychosis (JCEP) project were recruited. Patients who scored 6 or above in Calgary Depression Scale (CDS) were classified as having clinically significant depressive symptoms. Premorbid functioning was examined by Premorbid Adjustment Scale (PAS). Psychopathology was assessed with Positive and Negative Syndrome Scale (PANSS). Global functioning was measured using Social and Occupational Functioning Assessment Scale (SOFAS). Medication Compliance Questionnaire (MCQ) was used to assess patients’ attitude to treatment. Drug-induced Parkinsonism side-effects were evaluated using Simpson Angus Scale (SAS). A series of univariate analyses were conducted to determine relationship of “depressed clinical status” with potential predictive variables, followed by multivariate binary logistic regression to identify predictors of depressive symptoms. RESULTS: Fifty-two patients (14.8%) had clinically significant depressive symptoms at study entry. No significant difference between depressed and non-depressed patients in age at entry and onset, sex, premorbid adjustment and duration of untreated psychosis. Univariate analyses revealed significant associations of “depressive clinical status” with educational attainment (p<0.05), log-transformed duration of untreated illness (LogDUI) (p<0.05), SOFAS rating (p<0.05), PANSS positive (p<0.05) and negative symptom (p<0.05) subscale scores, SAS score (p<0.05) and MCQ attitude subscale score (p<0.05). Multivariate logistic regression indicated that more severe positive and negative symptoms, worse drug-induced Parkinsonism side-effects, and poorer attitude to medication treatment independently predicted occurrence of clinically significant depressive symptoms (Nagelkerke R2=0.215, p<0.001). Depressed patients had significantly poorer global functioning than non-depressed counterparts (t=3.6, p<0.01). DISCUSSION: In a large representative cohort of Chinese adult patients with first-episode non-affective psychotic disorders, approximately 15% experienced clinically significant depressive symptoms which were predicted by more severe positive and negative symptoms, higher level of antipsychotic-induced motor side-effects and poorer attitude to medication treatment.
DescriptionThis journal suppl. entitled: Abstracts of the 4th Biennial Schizophrenia International Research Conference
Persistent Identifierhttp://hdl.handle.net/10722/197703
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorChang, WCen_US
dc.contributor.authorChang, Ren_US
dc.contributor.authorHui, CLMen_US
dc.contributor.authorChan, KWen_US
dc.contributor.authorLee, HMEen_US
dc.contributor.authorChen, EYHen_US
dc.date.accessioned2014-05-29T08:43:28Z-
dc.date.available2014-05-29T08:43:28Z-
dc.date.issued2014en_US
dc.identifier.citationThe 4th Biennial Schizophrenia International Research Conference, Florence, Italy, 5-9 April 2014. In Schizophrenia Research, 2014, v. 153 suppl. 1, p. S267, poster no. M213en_US
dc.identifier.issn0920-9964-
dc.identifier.urihttp://hdl.handle.net/10722/197703-
dc.descriptionThis journal suppl. entitled: Abstracts of the 4th Biennial Schizophrenia International Research Conference-
dc.description.abstractBACKGROUND: Depressive symptoms are frequently found in the early stage of psychotic disorders and are associated with heightened risk of suicide. In this study, we aimed to examine the prevalence and factors predictive of the occurrence of depressive symptoms in adult patients presenting with first-episode non-affective psychosis to JCEP project in Hong Kong. METHODS: A total of 343 patients aged 26 to 55 years presenting with first-episode non-affective psychosis (DSM-IV schizophrenia, schizophreniform disorder, delusional disorder, brief psychotic disorder or psychosis NOS) to Jockey Club Early Psychosis (JCEP) project were recruited. Patients who scored 6 or above in Calgary Depression Scale (CDS) were classified as having clinically significant depressive symptoms. Premorbid functioning was examined by Premorbid Adjustment Scale (PAS). Psychopathology was assessed with Positive and Negative Syndrome Scale (PANSS). Global functioning was measured using Social and Occupational Functioning Assessment Scale (SOFAS). Medication Compliance Questionnaire (MCQ) was used to assess patients’ attitude to treatment. Drug-induced Parkinsonism side-effects were evaluated using Simpson Angus Scale (SAS). A series of univariate analyses were conducted to determine relationship of “depressed clinical status” with potential predictive variables, followed by multivariate binary logistic regression to identify predictors of depressive symptoms. RESULTS: Fifty-two patients (14.8%) had clinically significant depressive symptoms at study entry. No significant difference between depressed and non-depressed patients in age at entry and onset, sex, premorbid adjustment and duration of untreated psychosis. Univariate analyses revealed significant associations of “depressive clinical status” with educational attainment (p<0.05), log-transformed duration of untreated illness (LogDUI) (p<0.05), SOFAS rating (p<0.05), PANSS positive (p<0.05) and negative symptom (p<0.05) subscale scores, SAS score (p<0.05) and MCQ attitude subscale score (p<0.05). Multivariate logistic regression indicated that more severe positive and negative symptoms, worse drug-induced Parkinsonism side-effects, and poorer attitude to medication treatment independently predicted occurrence of clinically significant depressive symptoms (Nagelkerke R2=0.215, p<0.001). Depressed patients had significantly poorer global functioning than non-depressed counterparts (t=3.6, p<0.01). DISCUSSION: In a large representative cohort of Chinese adult patients with first-episode non-affective psychotic disorders, approximately 15% experienced clinically significant depressive symptoms which were predicted by more severe positive and negative symptoms, higher level of antipsychotic-induced motor side-effects and poorer attitude to medication treatment.-
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres-
dc.relation.ispartofSchizophrenia Researchen_US
dc.titlePrevalence And Predictors Of Depressive Symptoms In Non-Affective Psychosis Patients In Jockey Club Early Psychosis (Jcep) Project In Hong Kongen_US
dc.typeConference_Paperen_US
dc.identifier.emailChang, WC: changwc@hku.hken_US
dc.identifier.emailHui, CLM: christyh@hkucc.hku.hken_US
dc.identifier.emailChan, KW: kwsherry@hku.hken_US
dc.identifier.emailLee, HME: edwinlhm@hku.hken_US
dc.identifier.emailChen, EYH: eyhchen@hku.hken_US
dc.identifier.authorityChang, WC=rp01465en_US
dc.identifier.authorityChan, KW=rp00539en_US
dc.identifier.authorityLee, HME=rp01575en_US
dc.identifier.authorityChen, EYH=rp00392en_US
dc.identifier.doi10.1016/S0920-9964(14)70763-7-
dc.identifier.hkuros229003en_US
dc.identifier.volume153en_US
dc.identifier.issuesuppl. 1en_US
dc.identifier.spageS267, poster no. M213en_US
dc.identifier.epageS267, poster no. M213en_US
dc.publisher.placeNetherlands-

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