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Article: Study on the association between gene polymorphism of ENPP1 and left ventricular hypertrophy: A Guangzhou Biobank Cohort Study - CVD (in Chinese)

TitleStudy on the association between gene polymorphism of ENPP1 and left ventricular hypertrophy: A Guangzhou Biobank Cohort Study - CVD (in Chinese)
ENPP1基因多态位点与左心室肥厚的关系研究
Authors
Issue Date2010
PublisherChinese Medical Association [中華醫學會]. The Journal's web site is located at http://zhlxbx.periodicals.net.cn/
Citation
中華流行病學雜誌, 2010, v. 13 n. 7, p. 742-746 How to Cite?
Chinese Journal of Epidemiology , 2010, v. 13 n. 7, p. 742-746 How to Cite?
AbstractOBJECTIVE: To examine the association between genetic polymorphism of rs1409181 in ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and left ventricular hypertrophy (LVH) among older Chinese in Guangzhou. METHODS: 390 subjects aged >/= 50 years were randomly selected from the Guangzhou Biobank Cohort Study-CVD. Information on personal history, blood pressure, fasting plasma glucose and lipids were collected. Color Doppler ultrasound was used to measure the indicators of LVH, including left ventricular internal diastolic diameter (LVIDD), thickness of the interventricular septum diastolic wall (IVSD) and the posterior wall diastolic diameter (LVPWD). LVIDD was calculated using Devereux ventricular mass (LVM) equation while the Left ventricular mass index (LVMI) equation was used to estimate LVH. The genotype of rs1409181 was determined by Taqman SNP genotyping kits using the ABI 7900HT real time PCR system. RESULTS: In the GG, CG and CC genotype groups, the proportions of LVH were 21.5%, 28.2% and 37.5% respectively. Compared with GG, the adjusted odds ratios (95% confidence interval) for the LVH were 1.39 (0.78 - 2.50) and 2.36 (1.21 - 4.60) for CG genotype and CC genotype of ENPP1 respectively (P for trend = 0.01). CONCLUSION: Polymorphism of ENPP1 gene rs1409181 was associated with LVH in the older Chinese people in Guangzhou.
Persistent Identifierhttp://hdl.handle.net/10722/197271
ISSN
2015 SCImago Journal Rankings: 0.191

 

DC FieldValueLanguage
dc.contributor.authorJin, YLen_US
dc.contributor.authorLiu, Ben_US
dc.contributor.authorJiang, CQen_US
dc.contributor.authorXu, Len_US
dc.contributor.authorGuo, LHen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorLin, JMen_US
dc.contributor.authorZhang, Wen_US
dc.contributor.authorCheng, KKen_US
dc.contributor.authorThomas, GNen_US
dc.date.accessioned2014-05-23T02:32:04Z-
dc.date.available2014-05-23T02:32:04Z-
dc.date.issued2010en_US
dc.identifier.citation中華流行病學雜誌, 2010, v. 13 n. 7, p. 742-746en_US
dc.identifier.citationChinese Journal of Epidemiology , 2010, v. 13 n. 7, p. 742-746-
dc.identifier.issn0254-6450-
dc.identifier.urihttp://hdl.handle.net/10722/197271-
dc.description.abstractOBJECTIVE: To examine the association between genetic polymorphism of rs1409181 in ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and left ventricular hypertrophy (LVH) among older Chinese in Guangzhou. METHODS: 390 subjects aged >/= 50 years were randomly selected from the Guangzhou Biobank Cohort Study-CVD. Information on personal history, blood pressure, fasting plasma glucose and lipids were collected. Color Doppler ultrasound was used to measure the indicators of LVH, including left ventricular internal diastolic diameter (LVIDD), thickness of the interventricular septum diastolic wall (IVSD) and the posterior wall diastolic diameter (LVPWD). LVIDD was calculated using Devereux ventricular mass (LVM) equation while the Left ventricular mass index (LVMI) equation was used to estimate LVH. The genotype of rs1409181 was determined by Taqman SNP genotyping kits using the ABI 7900HT real time PCR system. RESULTS: In the GG, CG and CC genotype groups, the proportions of LVH were 21.5%, 28.2% and 37.5% respectively. Compared with GG, the adjusted odds ratios (95% confidence interval) for the LVH were 1.39 (0.78 - 2.50) and 2.36 (1.21 - 4.60) for CG genotype and CC genotype of ENPP1 respectively (P for trend = 0.01). CONCLUSION: Polymorphism of ENPP1 gene rs1409181 was associated with LVH in the older Chinese people in Guangzhou.-
dc.languagechien_US
dc.publisherChinese Medical Association [中華醫學會]. The Journal's web site is located at http://zhlxbx.periodicals.net.cn/-
dc.relation.ispartof中華流行病學雜誌en_US
dc.relation.ispartofChinese Journal of Epidemiology-
dc.subject.meshGenotype-
dc.subject.meshHypertrophy, Left Ventricular - genetics-
dc.subject.meshPhosphoric Diester Hydrolases - genetics-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.subject.meshPyrophosphatases - genetics-
dc.titleStudy on the association between gene polymorphism of ENPP1 and left ventricular hypertrophy: A Guangzhou Biobank Cohort Study - CVD (in Chinese)en_US
dc.titleENPP1基因多态位点与左心室肥厚的关系研究-
dc.typeArticleen_US
dc.identifier.emailJiang, CQ: cqjiang@HKUCC.hku.hken_US
dc.identifier.emailXu, L: xulin@hku.hken_US
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_US
dc.identifier.emailZhang, W: zhangws9@HKUCC-COM.hku.hken_US
dc.identifier.emailCheng, KK: chengkk@HKUCC.hku.hken_US
dc.identifier.emailThomas, GN: neilt@HKUCC.hku.hken_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.identifier.doi10.3760/cma.j.issn.0254-6450.2010.07.005-
dc.identifier.pmid21162834-
dc.identifier.hkuros183885en_US
dc.identifier.volume13en_US
dc.identifier.issue7en_US
dc.identifier.spage742en_US
dc.identifier.epage746en_US
dc.publisher.placeChina-

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